Screening for protein adducts of naphthalene and chrysene in plasma of exposed Atlantic cod (Gadus morhua)

Covalent Protein Modification: An Unignorable Factor for Bisphenol A-Induced Hepatotoxicity

“…However, the covalent modification by pollutants or their RMs is rarely investigated in vivo at the proteome-wide level. Protein adduct formation might give rise to toxicity through disrupting protein structures and/or functions or provoking immune response and hypersensitivity, followed by a series of downstream effects. , In addition, the adducted proteins are usually stable and not removed via the active repair process; thus, they could accumulate during the lifespan of a protein and lead to a longer duration of effects compared to pollutants and their metabolites. , Also, protein adducts have been validated as a sensitive biomarkers of low-dose exposure to environmental pollutants, such as polycyclic aromatic hydrocarbons and organophosphorus. − Thus, the investigation on covalent modification of environmental pollutants on proteins is necessary for a comprehensive understanding of the action mechanism of toxicity and the development of potential biomarkers of the exposure effect that can be used in health risk assessment.…”

The crystal structure of haemoglobin from Atlantic cod

“…Environmental pollutants such as polycyclic aromatic hydrocarbons (PAHs), resulting for example from oil exploration and production operations or accidental oil spills, have received attention from researchers since the 1970s owing to their carcinogenic potential (United States Environmental Protection Agency, 2009). However, only in recent years, with the development of new and more sensitive analytical methods, has it become possible to obtain a deeper understanding of the adverse effects and the mode of action of these contaminants (Beyer et al, 2011;Enerstvedt, Sydnes, Larssen et al, 2018;Enerstvedt et al, 2017;Karlsen et al, 2011).…”