Screening for Retinoblastoma: Presenting Signs as Prognosticators of Patient and Ocular Survival

Abramson, David H.; Beaverson, Katherine; Sangani, Poorab K.; Vora, Robin; Lee, Thomas C; Hochberg, Hilary M; Kirszrot, James; Ranjithan, Murali

doi:10.1542/peds.112.6.1248

Cited by 191 publications

(156 citation statements)

References 21 publications

Supporting

Mentioning

136

Contrasting

Unclassified

Order By: Relevance

“…The 5-year survival rate of retinoblastoma is 80% in Taiwan, which is lower than that reported in Europe (95%), 5 in the United States (493%), 14 and in Japan (10-year survival rate was 86.7% in bilateral cases and 92.3% in unilateral cases), 7 but close to that reported in Singapore (3-year survival rate was 83%). 6 In this study, all of the deaths occurred within the first 5 years after diagnosis, a finding consistent with data from Singapore.…”

Section: Discussionmentioning

confidence: 46%

Retinoblastoma in Taiwan: incidence and survival characteristics from 1979 to 2003

Chen

Lin

Hsu

et al. 2009

Eye

View full text Add to dashboard Cite

Purpose To describe the incidence and survival rate of patients with retinoblastoma in Taiwan over a 25-year period, from 1979 to 2003. Methods Cases of retinoblastoma have been reported to the Taiwan National Cancer Registry (TNCR) since 1979. Retinoblastoma data from 1979 to 2003 were retrieved from the TNCR databank for analysis of both the incidence and survival rate. Trends in the incidence rate were estimated by calculating the annual percentage change (APC).Results From 1979 to 2003, a total of 380 patients (182 [47.9%] females) with retinoblastoma were identified. Of the 380 cases, 359 patients (94.5%) were diagnosed before 5 years of age. The average annual agestandardized incidence rate was 4.45 per million in children under 10 years of age and 8.58 per million in children under 5 years of age. There was a significant increasing trend in the incidence rate over the study period with an APC of 2.3% (P ¼ 0.035). Before the implementation of Taiwan's National Health Insurance (NHI) Program in 1995, the mean age at diagnosis was 4.8 ± 13.3 years and the 5-year survival rate was 74.7%. After implementation of the NIH Program, the mean age at diagnosis decreased to 1.6 ± 2.1 years (Po0.001) and the 5-year survival rate increased to 84.7% (P ¼ 0.063). Conclusions We report the first populationbased study on retinoblastoma in Taiwan. There was a significant increasing trend in the incidence rate from 1979 to 2003. Since the implementation of Taiwan's NHI, the mean diagnostic age decreased.

show abstract

Section: Discussionmentioning

confidence: 46%

Retinoblastoma in Taiwan: incidence and survival characteristics from 1979 to 2003

Chen

Lin

Hsu

et al. 2009

Eye

View full text Add to dashboard Cite

show abstract

“…In their series (only screened children) Imhof et al reported similar findings with more than 70% of their patients being diagnosed within the first 2 weeks of life and 82% being in the RE group I, II, or III. 2,4,5,11,12 Although patients in the I, II, or III group of the RE classification or in the A, B, or C group of the ICR are usually amenable to an eye conservation strategy (most often systemic chemotherapy combined with focal treatments), patients with more advanced disease (group IV, V and D, E) often require aggressive treatment such as enucleation or EBRT despite chemoreduction. 3,13 These results tend to suggest an association between intensive screening and early diagnosis, which probably explains the lower stages of the disease found in screened children.…”

Section: Discussionmentioning

confidence: 99%

“…Only few studies have shown interesting results in terms of ocular conservation and final visual acuity (VA) in patients with positive family history screened early-in-life by fundus examinations at regular intervals and under general anaesthesia. 2,[4][5][6] Nevertheless, these were small uncontrolled studies with poorly defined screening schedules and included patients treated before the advent of chemotherapy as a first-line treatment for almost all familial RB patients.…”

Section: Introductionmentioning

confidence: 99%

Familial retinoblastoma: fundus screening schedule impact and guideline proposal. A retrospective study

Rothschild

Lévy

Savignoni

et al. 2011

Eye

View full text Add to dashboard Cite

show abstract

“…This increase in vascular density is common to most tumours, although there are some exceptions; pituitary tumours, for example, show higher intercapillary distances than the equivalent healthy tissue (Turner et al, 2000). In some tumours, such as retinoblastoma or nephroblastoma, vascular density is used as a criterion for prognosis (Abramson et al, 2003;Rössler et al, 2004) because of the higher risk of metastasis and better access of the tumour cells to nutrients and oxygen. Finally, it is important to point out that the mean vascular diameter of teratocarcinoma is about 2.4 times wider than in the normal testis.…”

Section: Discussionmentioning

confidence: 99%

Angiogenesis and vascular network of teratocarcinoma from embryonic stem cell transplant into seminiferous tubules

et al. 2009

View full text Add to dashboard Cite

BACKGROUND: Carcinoma in situ (CIS) of the testis is considered to be a precancerous germinal cell lesion, but the precise cellular and molecular mechanisms underlying transformation of CIS into invasive pluripotent cancer cells remain to be elucidated. Moreover, a satisfactory animal model for the experimental study of germinal tumours has not been developed to date. METHODS: We have developed a tumour model that involves the microinjection of green fluorescent protein-labelled embryonic stem (ES) cells (which are functionally equivalent to CIS cells) into syngenic mouse seminiferous tubules, a unique cell microenvironment in which germinal cells mature and CIS arise. To characterise the vascularisation of teratocarcinomas, which arise after cell transplant, we used immunohistochemistry, together with a qualitative and quantitative analysis of scanning electron microscopy images of corrosion casting samples. RESULTS: Embryonic stem cells transplanted into seminiferous tubules did not differentiate into germinal cells, but rather they behaved as invasive embryonal carcinoma (EC) stem cells. The vascular pattern of the experimental teratocarcinomas showed a highly disorganised architecture, and some of the neoplastic capillaries were derived, at least in part, from the original transplanted ES cells. CONCLUSION: The transplantation of pluripotent ES cells into seminiferous tubules efficiently recapitulates the early stages of development of teratocarcinomas. Consequently, this method constitutes a novel in vivo model to study the mechanisms of invasion and progression of experimental germinal tumours.

show abstract

Screening for Retinoblastoma: Presenting Signs as Prognosticators of Patient and Ocular Survival

Cited by 191 publications

References 21 publications

Retinoblastoma in Taiwan: incidence and survival characteristics from 1979 to 2003

Retinoblastoma in Taiwan: incidence and survival characteristics from 1979 to 2003

Familial retinoblastoma: fundus screening schedule impact and guideline proposal. A retrospective study

Angiogenesis and vascular network of teratocarcinoma from embryonic stem cell transplant into seminiferous tubules

Contact Info

Product

Resources

About