Screening for retinopathy of prematurity and treatment outcome in a tertiary hospital in Hong Kong

Iu, Lawrence P.; Lai, Chun; Fan, Ming-Hui; Wong, Ian Yh; Lai, Jian-pu

doi:10.12809/hkmj154811

Cited by 9 publications

(17 citation statements)

References 27 publications

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“…62 Several studies have reported that presence and/or treatments for PDA are risk factors for ROP. 36,150,184,189,220,257,266,367,387 A study of 487 infants in Turkey found that PDA was an independent risk factor for severe ROP. 29…”

Section: Alternative Risk Factorsmentioning

confidence: 99%

Retinopathy of prematurity: a review of risk factors and their clinical significance

Kim

Port

Swan

et al. 2018

Survey of Ophthalmology

416

337

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Retinopathy of prematurity (ROP) is a retinal vasoproliferative disease that affects premature infants. Despite improvements in neonatal care and management guidelines, ROP remains a leading cause of childhood blindness worldwide. Current screening guidelines are primarily based on two risk factors: birth weight and gestational age; however, many investigators have suggested other risk factors, including maternal factors, prenatal and perinatal factors, demographics, medical interventions, comorbidities of prematurity, nutrition, and genetic factors. We review the existing literature addressing various possible ROP risk factors. Although there have been contradictory reports, and the risk may vary between different populations, understanding ROP risk factors is essential to develop predictive models, to gain insights into pathophysiology of retinal vascular diseases and diseases of prematurity, and to determine future directions in management of and research in ROP.

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Section: Alternative Risk Factorsmentioning

confidence: 99%

Retinopathy of prematurity: a review of risk factors and their clinical significance

Kim

Port

Swan

et al. 2018

Survey of Ophthalmology

416

337

View full text Add to dashboard Cite

show abstract

“…Various studies across the world have shown an incidence of ROP ranging from 9.3 to 37.8% in infants with the mean birth weights (BWs) ranging from 846 to 1301 grams (g) and the gestational ages (GAs) ranging from 27 to 29 weeks. [ 5 6 7 8 9 ] The spectrum of ROP predominantly reported includes stage I ROP in 32–60% with few babies progressing to stage V ROP. [ 5 6 7 8 9 ] The prevalence of severe ROP has been reported to range from 1.5 to 11.7%.…”

mentioning

confidence: 99%

“…[ 5 6 7 8 9 ] The spectrum of ROP predominantly reported includes stage I ROP in 32–60% with few babies progressing to stage V ROP. [ 5 6 7 8 9 ] The prevalence of severe ROP has been reported to range from 1.5 to 11.7%. [ 5 6 7 8 9 ]…”

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confidence: 99%

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Five-year demographic profile of retinopathy of prematurity at a tertiary care institute in North India

Tekchandani

Katoch

Dogra

2021

Indian Journal of Ophthalmology

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Purpose: The purpose of this study is to study the demographic profile and pattern of retinopathy of prematurity (ROP) at a tertiary care institute in India. Methods: An ambispective study from January 2013 to December 2017. Infants with birth weights (BWs) <1750 g and gestational ages <34 weeks were screened for ROP. Demographic details and ROP severity were recorded. Results: Data of 2595 of the 3697 infants screened were analyzed. The number of infants screened and treated for ROP increased from 190 and 29, respectively (2013), to 818 and 132, respectively (2017). The overall incidence of “any ROP” was 32.3%, and severe ROP was 17.7%. Though 39.5% of all infants were outborns (not born in the study center), severe ROP was present in 69.7% of these compared to 18.8% among inborns. Outborns with ROP had a higher mean BW (1308 g) compared to inborns (1202 g) ( P < 0.01). ROP Stage 1 was seen in 12%, Stage 2 in 34%, Stage 3 in 13%, Stage 4 in 6%, Stage 5 in 14%, and aggressive posterior ROP (APROP) in 20%. APROP was seen in 16% of infants in 2013, 10% in 2014, 15% in 2015, 22% in 2016, and 28% in 2017. Infants with Stage 4B/Stage5 (15.6% of all ROP) were presented at a mean age of 7.5 months and all had no/delayed screening. Conclusion: Incidence of any ROP was 32.3% and was more common in outborns than inborns. The proportion of infants with APROP showed a rising trend over the years. Nearly 15.6% of infants were presented with stage4B/5 ROP due to delayed/absent screening.

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“…ROP is characterized by two distinct pathological processes: an early ischemic/hyperoxia stage when the undeveloped retinal vessels are damaged by high oxygen concentration, resulting in the cessation of vascular development and the formation of retinal avascular area, 5 a late hypoxic stage when the retina is subjected to the increase of hypoxia‐inducible factor 1α (HIF‐1α) signaling pathway and vascular endothelial growth factor (VEGF) level, which further leads to the formation of retinal neovascularization (RNV) 6 . With the increased popularity of ROP screening in preterm infants and improved diagnostic rate in some developing and developed countries, most ROP cases are early‐stage 7‐10 . Notably, the early recommendations in the ROP treatment guidelines are only for regular follow‐up observation without an effective treatment 11,12 .…”

Section: Introductionmentioning

confidence: 99%

Adenosine A_2A receptor antagonism protects against hyperoxia‐induced retinal vascular loss via cellular proliferation

Zhong

Zhang

et al. 2021

The FASEB Journal

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Screening for retinopathy of prematurity and treatment outcome in a tertiary hospital in Hong Kong

Cited by 9 publications

References 27 publications

Retinopathy of prematurity: a review of risk factors and their clinical significance

Retinopathy of prematurity: a review of risk factors and their clinical significance

Five-year demographic profile of retinopathy of prematurity at a tertiary care institute in North India

Adenosine A_2A receptor antagonism protects against hyperoxia‐induced retinal vascular loss via cellular proliferation

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Screening for retinopathy of prematurity and treatment outcome in a tertiary hospital in Hong Kong

Cited by 9 publications

References 27 publications

Retinopathy of prematurity: a review of risk factors and their clinical significance

Retinopathy of prematurity: a review of risk factors and their clinical significance

Five-year demographic profile of retinopathy of prematurity at a tertiary care institute in North India

Adenosine A2A receptor antagonism protects against hyperoxia‐induced retinal vascular loss via cellular proliferation

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Product

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Adenosine A_2A receptor antagonism protects against hyperoxia‐induced retinal vascular loss via cellular proliferation