Screening for spondyloarthritis in patients with inflammatory bowel diseases

Ottaviani, Sébastien; Forien, Marine; Coralli, Romain; Dauchez, Astrid; Stefănescu, Carmen; Pelletier, Anne-Laure; Bécheur, Hakim; Ebstein, Esther; Bouhnik, Yoram; Dieudé, Philippe

doi:10.1007/s00296-022-05208-y

Cited by 5 publications

(2 citation statements)

References 25 publications

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“…Kelly et al [17] reported association of sacroiliitis with male sex, history of peripheral arthritis and Crohn's disease inflammatory phenotype [17]. Standardized MRI of sacroiliac joint (SIJ) showed sacroiliitis in 12-39% of patients with IBD [23][24][25][26] and this wide range was again due to differences in MRI interpretations in these studies (e.g. ASAS definition of MRI positivity vs. inclusion/exclusion of structural lesions).…”

Section: Prevalence Of Inflammatory Bowel Disease Associated Sacroili...mentioning

confidence: 99%

Sacroiliitis in inflammatory bowel disease

Malik,

Weisman

2024

Current Opinion in Rheumatology

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Purpose of review This review summarizes the recent evidence regarding the epidemiology of inflammatory bowel disease (IBD) associated sacroiliitis, including the prevalence, pathogenesis, role of imaging, and therapeutic challenges. Recent findings Sacroiliitis is an underappreciated musculoskeletal manifestation of IBD, a chronic inflammatory condition of the gut affecting the younger population. Untreated sacroiliitis can lead to joint destruction and chronic pain, further adding to morbidity in IBD patients. Recent publications suggest sacroiliitis can be detected on abdominal imaging obtained in IBD patients to study bowel disease, but only a small fraction of these patients were seen by rheumatologists. Early detection of IBD-associated sacroiliitis could be achieved by utilization of clinical screening tools in IBD clinics, careful examination of existing computed tomography and MRI studies, and timely referral to rheumatologist for further evaluation and treatment. Current treatment approaches for IBD and sacroiliitis include several targeted biologic therapies, but IBD-associated sacroiliitis has limited options, as these therapies may not overlap in both conditions. Summary With the advances in imaging, sacroiliitis is an increasingly recognized comorbidity in IBD patients. Future studies focusing on this unique patient population will expand our understanding of complex pathophysiology of IBD-associated sacroiliitis and lead to identification of novel targeted therapies for this condition.

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Section: Prevalence Of Inflammatory Bowel Disease Associated Sacroili...mentioning

confidence: 99%

Sacroiliitis in inflammatory bowel disease

Malik,

Weisman

2024

Current Opinion in Rheumatology

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“…An observational two-year cross-sectional study reported that 30% of IBD patients with musculoskeletal complaints for more than three months had SpA. SpA occurred more frequently in men and patients with surgery for IBD [ 135 ]. They accounted for about 40% of all extraintestinal manifestations and manifest mainly as axial or peripheral spondyloarthritis.…”

Section: The Bone As Frequent Target Of Extraintestinal Ibd Manifesta...mentioning

confidence: 99%

Pivotal Role of Intestinal Microbiota and Intraluminal Metabolites for the Maintenance of Gut–Bone Physiology

Grüner

Ortlepp

Mattner

2023

IJMS

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Intestinal microbiota, and their mutual interactions with host tissues, are pivotal for the maintenance of organ physiology. Indeed, intraluminal signals influence adjacent and even distal tissues. Consequently, disruptions in the composition or functions of microbiota and subsequent altered host–microbiota interactions disturb the homeostasis of multiple organ systems, including the bone. Thus, gut microbiota can influence bone mass and physiology, as well as postnatal skeletal evolution. Alterations in nutrient or electrolyte absorption, metabolism, or immune functions, due to the translocation of microbial antigens or metabolites across intestinal barriers, affect bone tissues, as well. Intestinal microbiota can directly and indirectly alter bone density and bone remodeling. Intestinal dysbiosis and a subsequently disturbed gut–bone axis are characteristic for patients with inflammatory bowel disease (IBD) who suffer from various intestinal symptoms and multiple bone-related complications, such as arthritis or osteoporosis. Immune cells affecting the joints are presumably even primed in the gut. Furthermore, intestinal dysbiosis impairs hormone metabolism and electrolyte balance. On the other hand, less is known about the impact of bone metabolism on gut physiology. In this review, we summarized current knowledge of gut microbiota, metabolites and microbiota-primed immune cells in IBD and bone-related complications.

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