Screening for spontaneous preterm birth by cervical length and shear-wave elastography in the first trimester of pregnancy

Feng, Qiang; Chaemsaithong, Piya; Duan, Honglei; Ju, Xiaoqing; Appiah, Kubi; Shen, Lixia; Wang, Xueqin; Tai, Yi-Yun; Leung, Tak Yeung; Poon, Liona C.

doi:10.1016/j.ajog.2022.04.014

Cited by 15 publications

(9 citation statements)

References 43 publications

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“…Eventually, 15 studies met the eligibility criteria and were included (Figure 1). 10,19,20,[22][23][24][25][26][27][28][29][30][31][32][33]…”

Section: Study Selectionmentioning

confidence: 99%

RETRACTED: Diagnostic accuracy of cervical elastography for predicting preterm delivery: Systematic review and meta-analysis

Sun,

Lv,

Liu

et al. 2023

Scott Med J

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Objective Cervical elastography has been used in pregnant women to diagnose preterm births. However, there is a variability in the measured elasticity parameters and imaging mode used. We evaluated the precision of cervical elastography in identifying preterm births. Methods Extensive and methodical searches were made in the databases such as Scopus, Embase, Cochrane Library, PubMed Central, Medline, ScienceDirect, and Google Scholar from the inception until November 2022, for studies that report diagnostic accuracy of cervical elastography for preterm deliveries in antenatal women. Results The pooled sensitivity and specificity value of cervical elastography for preterm deliveries were 82% (95%CI: 73%–89%) and 77% (95%CI: 64%–86%), respectively with area under curve (AUC) of 0.87 (95%CI: 0.72–0.95). The diagnostic odds ratio (DOR) was 15 (95%CI: 8–28), positive likelihood ratio (LRP) was 3.5 (95%CI: 2.3–5.5) and negative likelihood ratio LRN was 0.23 (0.16–0.34). Pooled sensitivity and specificity of shear wave elastography was 88% and 71%, respectively. Pooled sensitivity and specificity of strain elastography was 80% and 79%, respectively. Heterogeneity was significant, as indicated by chi-square test and an I2 statistic of over 75. Conclusions Cervical elastography can be used for predicting preterm deliveries with moderate to high level of accuracy.

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“…Eventually, 15 studies met the eligibility criteria and were included (Figure 1). 10,19,20,[22][23][24][25][26][27][28][29][30][31][32][33]…”

Section: Study Selectionmentioning

confidence: 99%

RETRACTED: Diagnostic accuracy of cervical elastography for predicting preterm delivery: Systematic review and meta-analysis

Sun,

Lv,

Liu

et al. 2023

Scott Med J

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“…23 Additional methods to predict the onset of labour (eg, cervical elastography, immune markers, and genetic markers) should be explored to improve accuracy. 24,25 Prophylactic progesterone is effective in reducing the risk of preterm delivery among women who have a short cervix. 26 Although the use of a cervical ring pessary reportedly had a similar effect in a Spanish study, 27 this result was not confirmed by a randomised controlled trial in Hong Kong 28 or by subsequent meta-analysis.…”

Section: Neonatal Death Due To Prematuritymentioning

confidence: 99%

Neonatal mortality in singleton pregnancies: a 20-year retrospective study from a tertiary perinatal unit in Hong Kong

et al. 2022

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Introduction:The global neonatal death (NND) rate has been declining in recent decades, but there are no comprehensive data concerning the characteristics of NNDs in Hong Kong. This study investigated the trends and aetiologies of NNDs among singleton pregnancies in Hong Kong. Methods:This study included all cases of NND from singleton pregnancies in a tertiary hospital in Hong Kong between 2000 and 2019. The rates, clinical characteristics, and aetiologies of NND were compared between the first (2000)(2001)(2002)(2003)(2004)(2005)(2006)(2007)(2008)(2009) and the second (2010-2019) decades. Results:The NND rate decreased from 1.66/1000 livebirths (97 cases) in the first decade to 1.32/1000 livebirths (87 cases) in the second decade. Congenital or genetic abnormalities (82 cases) caused 44.6% of all NNDs. There was a significant reduction from 0.82/1000 livebirths in the first decade to 0.52/1000 livebirths in the second decade (P=0.037). Other causes of NND were prematurity (69 cases; 37.5%), sepsis (16 cases; 8.7%), hypoxic-ischaemic encephalopathy (15 cases; 8.2%), and sudden infant death syndrome (2 cases; 1.1%). Gestational agespecific neonatal mortality for moderately preterm neonates (31-33 weeks of gestation) significantly decreased from 34.73/1000 in 2000-2009 to

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“…We identified 17 published studies focusing on predictive capabilities of cervical ultrasound for sPTB. Among them, nine studies utilized strain elastography (SE) [ 15 ] [ 17 ] [ 18 ] [ 19 ] [ 27 ] [ 28 ]–[ 37 ] and eight employed shear wave elastography (SWE) [ 22 ] [ 23 ] [ 29 ] [ 30 ] [ 33 ] [ 34 ] [ 35 ] [ 36 ]. Sixteen of 17 studies concluded that cervical elastography could predict preterm birth.…”

Section: Discussionmentioning

confidence: 99%

Evaluating the Efficacy of Cervical Tactile Ultrasound Technique as a Predictive Tool for Spontaneous Preterm Birth

Egorov,

Rosen,

Hill

et al. 2024

OJOG

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Background: Premature cervical softening and shortening may be considered an early mechanical failure that predispose to preterm birth. Purpose: This study aims to explore the applicability of an innovative cervical tactile ultrasound approach for predicting spontaneous preterm birth (sPTB). Materials and Methods: Eligible participants were women with low-risk singleton pregnancies in their second trimester, enrolled in this prospective observational study. A Cervix Monitor (CM) device was designed with a vaginal probe comprising four tactile sensors and a single ultrasound transducer operating at 5 MHz. The probe enabled the application of controllable pressure to the external cervical surface, facilitating the acquisition of stress-strain data from both anterior and posterior cervical sectors. Gestational age at delivery was recorded and compared against cervical elasticity. Results: CM examination data were analyzed for 127 women at 24 0/7 - 28 6/7 gestational weeks. sPTB was observed in 6.3% of the cases. The preterm group exhibited a lower average cervical stress-to-strain ratio (elasticity) of 0.70 ± 0.26 kPa/mm compared to the term group’s 1.63 ± 0.65 kPa/mm with a p-value of 1.1 × 10 −4 . Diagnostic accuracy for predicting spontaneous preterm birth based solely on cervical elasticity data was found to be 95.0% (95% CI, 88.5 – 100.0). Conclusion: These findings suggest that measuring cervical elasticity with the designed tactile ultrasound probe has the potential to predict spontaneous preterm birth in a cost-effective manner.

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Screening for spontaneous preterm birth by cervical length and shear-wave elastography in the first trimester of pregnancy

Cited by 15 publications

References 43 publications

RETRACTED: Diagnostic accuracy of cervical elastography for predicting preterm delivery: Systematic review and meta-analysis

RETRACTED: Diagnostic accuracy of cervical elastography for predicting preterm delivery: Systematic review and meta-analysis

Neonatal mortality in singleton pregnancies: a 20-year retrospective study from a tertiary perinatal unit in Hong Kong

Evaluating the Efficacy of Cervical Tactile Ultrasound Technique as a Predictive Tool for Spontaneous Preterm Birth

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