Screening for Streptococcus pyogenes antibacterial and Candida albicans antifungal bioactivities of organic compounds in natural essential oils of Piper betle L., Cleistocalyx operculatus L. and Ageratum conyzoides L.

Thuý, Bùi Thị Phương; Hiếu, Lê Trung; My, Tran Thi Ai; Hai, Nguyen Thi Thanh; Loan, Huynh Thi Phuong; Thủy, Nguyễn Thị Thu; Triet, Nguyen Thanh; Anh, Trần Thị Vân; Dieu, Nguyen Thi Xuan; Quy, Phan Tu; Trung, Nguyen Van; Quang, Duong Tuan; Huynh, Lam K.; Nhung, Nguyen Thi Ai

doi:10.1007/s11696-020-01404-x

Cited by 8 publications

(3 citation statements)

References 36 publications

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“…Eugenol was also reported to induce fungal morphological abnormalities by changing or disrupting fungal cell wall structure, increasing cell membrane fluidity and permeability, and interfering with important regulator function [ 44 ]. Furthermore, docking simulation of eugenol acetate and chavicol acetate in BLEO showed strong interaction to amino acid constructing fungal protein structures, which is predicted to cause metabolic reduction and biomass breaking down, thus reducing fungal virulence [ 45 ].…”

Section: Antifungal Properties Of Betel Leavesmentioning

confidence: 99%

Piper betle (L): Recent Review of Antibacterial and Antifungal Properties, Safety Profiles, and Commercial Applications

et al. 2021

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Piper betle (L) is a popular medicinal plant in Asia. Plant leaves have been used as a traditional medicine to treat various health conditions. It is highly abundant and inexpensive, therefore promoting further research and industrialization development, including in the food and pharmaceutical industries. Articles published from 2010 to 2020 were reviewed in detail to show recent updates on the antibacterial and antifungal properties of betel leaves. This current review showed that betel leaves extract, essential oil, preparations, and isolates could inhibit microbial growth and kill various Gram-negative and Gram-positive bacteria as well as fungal species, including those that are multidrug-resistant and cause serious infectious diseases. P. betle leaves displayed high efficiency on Gram-negative bacteria such as Escherichia coli and Pseudomonas aeruginosa, Gram-positive bacteria such as Staphylococcus aureus, and Candida albicans. The ratio of MBC/MIC indicated bactericidal and bacteriostatic effects of P. betle leaves, while MFC/MIC values showed fungicidal and fungistatic effects. This review also provides a list of phytochemical compounds in betel leaves extracts and essential oils, safety profiles, and value-added products of betel leaves. Some studies also showed that the combination of betel leaves extract and essential oil with antibiotics (streptomycin, chloramphenicol and gentamicin) could provide potentiating antibacterial properties. Moreover, this review delivers a scientific resume for researchers in respected areas and manufacturers who want to develop betel leaves-based products.

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Section: Antifungal Properties Of Betel Leavesmentioning

confidence: 99%

Piper betle (L): Recent Review of Antibacterial and Antifungal Properties, Safety Profiles, and Commercial Applications

et al. 2021

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“…These results appear to differ from other locations' oil chemical compositions when compared to the literature. Indeed, the major components of essential oils from Phong Dien, Thua Thien Hue (Vietnam) were (E)-β-ocimene (52.9%), (Z)-β-ocimene (10.9%), caryophyllene (8.1%), humulene (2.5%), γ-muurolene (2.0%), and epiglobulol (2.1%); those of Vinh, Nghe An (Vietnam) were (Z)-β-ocimene (32.1%), (E)β-ocimene (9.4%), myrcene (24.6%), and β-caryophyllene (14.5%); and those of Nepal were myrcene (69.70%), (E)-β-ocimene (12.24%), (Z)-β-ocimene (4.79%), linalool (4.08%), p-cymene (2.71%), (E)-caryophyllene (1.11%), and (E)-Nerolidol (1.57%) [12,19,20]. The observed dissimilarity in the quality and content of these essential oils might be attributed to the distribution of species, as well as differences in analysis and identification methods.…”

Section: Percentage Yield and Chemical Composition Of C Operculatus E...mentioning

confidence: 99%

Chemical Composition, Anti-α-Glucosidase Activity, and Molecular Modelling Studies of Cleistocalyx operculatus Essential Oil

Tran,

Nguyen,

Pham

et al. 2023

Applied Sciences

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In this study, chemical components, α-glucosidase inhibitory activities, and molecular modelling studies of the essential oil extracted from the Cleistocalyx operculatus leaves were investigated. In total, thirty compounds were identified using GC/MS, representing 98.3% of the oil. Of these, the two most dominant constituents of the essential oil were determined as (Z)-β-ocimene (30.4%) and allo-ocimene (31.6%). The α-glucosidase inhibitory experiments indicated that the essential oil exhibited potent α-glucosidase inhibitory activities, with IC50 values of 61.82 ± 3.91 µg/mL. For further investigation into inhibitory mechanisms, molecular docking simulations were performed to investigate structural interactions between two dominant constituents and the α-glucosidase protein. The simulation revealed that allo-ocimene (31.6%) and (Z)-β-ocimene (30.4%) have protein binding affinities of −5.358 and −5.330 kcal/mol, respectively. Moreover, molecular dynamic simulation indicated that the complexes of two compounds and the target protein were stable over 100 ns. Overall, these findings suggest that the essential oil of C. operculatus leaves could be a natural source of potential α-glucosidase inhibitors.

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“…Essential oils from plants have been widely used in medicine, agriculture, perfumery, and cosmetics (Paolini, et al, 2010;Thuy, et al, 2021;Maia, et al, 2019;Křůmal, et al, 2015;Razavi, et al, 2021;Saikia, et al, 2020;Stojanović-Radić, et al, 2020). Several research groups are currently conducting studies on the chemical composition and biological potential of essential oils extracted from numerous plants, such as Vismia Vand.…”

Section: Introductionmentioning

confidence: 99%

Chemical Composition and Biological Activities of Essential Oils from Fresh Vismia guianensis (Aubl.) Choisy and Vismia cayennensis (Jacq.) Pers. Leaves

Barbosa

Silva

et al. 2021

RSD

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The Vismia Vand. genus encompasses many species indigenous to the Amazon rain forest where they are popularly known as “Lacre” bark and leaves are widely employed by locals to treat dermatophytoses. The aim of this study was to investigate the chemical composition of essential oils (EOs) extracted from the aerial parts of the species Vismia guianensis (Aubl.) Choisy and Vismia cayennensis (Jacq.) Pers. and to assess their antimicrobial activity against the bacteria Staphylococcus aureus Rosenbach 1884 and Escherichia coli (Migula 1895) Castellani and Chalmers 1919 as well as the fungi Candida albicans (C.P. Robin) Berkhout 1923 and Candida parapsilosis (Ashford) Langeron & Talice 1932. The analysis of the chemical composition of the essential oil extracted from V. guianensis leaves (EOVg) indicated 46 components, of which three sesquiterpenes predominated, namely: (E)-caryophyllene (10.40%), α-copaene (29.45%), and (E)-nerolidol (24.06%). As to the essential oil from V. cayennensis leaves (EOVc), 61 components were identified, of which two oxygenated sesquiterpenes stood out as the main components, namely, germacrone (25.42%) and curzerene (25.29%). EOVg exhibited Minimum Inhibitory Concentration (MIC) of 1.56 µg/mL against the yeast C. parapsilosis whereas EOVc was active against the bacteria E. coli and S. aureus as well as the yeast C. parapsilosis. The results obtained in this study strongly recommend further research on the essential oils in question with a view to isolating and identifying the components responsible for their observed antimicrobial activities.

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Screening for Streptococcus pyogenes antibacterial and Candida albicans antifungal bioactivities of organic compounds in natural essential oils of Piper betle L., Cleistocalyx operculatus L. and Ageratum conyzoides L.

Cited by 8 publications

References 36 publications

Piper betle (L): Recent Review of Antibacterial and Antifungal Properties, Safety Profiles, and Commercial Applications

Piper betle (L): Recent Review of Antibacterial and Antifungal Properties, Safety Profiles, and Commercial Applications

Chemical Composition, Anti-α-Glucosidase Activity, and Molecular Modelling Studies of Cleistocalyx operculatus Essential Oil

Chemical Composition and Biological Activities of Essential Oils from Fresh Vismia guianensis (Aubl.) Choisy and Vismia cayennensis (Jacq.) Pers. Leaves

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