Screening for thyroid disease among children and adolescents with type 1 diabetes mellitus

Omar, Magdy; Rizk, Mohamed M.; El-Kafoury, Ahmed A.; Kilany, Doaa

doi:10.1016/j.ajme.2013.09.001

Cited by 8 publications

(18 citation statements)

References 13 publications

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“…On the other hand, hyperthyroidism can worsen glycemic control and increases the risk of diabetic ketoacidosis [ 26 ] and neuromuscular dysfunction [ 27 ]. Therefore, our findings concur with studies in other populations [ 7 , 28 ] that screening for thyroid function and autoantibody among patients with type 1 diabetes is recommended. According to the most current practice guidelines, the American Diabetes Association recommends screening children newly diagnosed with type 1 diabetes for autoimmune thyroid disease by measuring antithyroid peroxidase and antithyroglobulin.…”

Section: Discussionsupporting

confidence: 92%

Higher Risk of Thyroid Disorders in Young Patients with Type 1 Diabetes: A 12-Year Nationwide, Population-Based, Retrospective Cohort Study

Chang²,

Huang

et al. 2016

PLoS ONE

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BackgroundThe association between type 1 diabetes and thyroid autoimmunity has been studied in various populations, but seldom on Taiwanese children and adolescents. Therefore, the aim of this study was to examine the incidence of autoimmune thyroid disorders in Taiwanese children and adolescent patients with type 1 diabetes, based on data from a nationwide, population-based, health claims database.MethodsUsing Taiwan’s National Health Insurance Research Database, we identified 3,652 patients with type 1 diabetes between 2000 and 2012. A comparison cohort was assembled, which consisted of five patients without type 1 diabetes, based on frequency matching for sex and 3-year age interval, for each patient with type 1 diabetes. Both groups were followed until diagnosis of thyroid disorders or the end of the follow-up period. Poisson regression models were used to calculate incidence rate ratios for the thyroid disorders between the type 1 diabetes cohort and the comparison cohort.ResultsSimple and unspecified goiter (International Classification of Diseases, 9th Revision, Clinical Modification [ICD-9-CM] code 240), thyrotoxicosis (ICD-9-CM code 242), unspecified hypothyroidism (ICD-9-CM code 244.9), and thyroiditis (ICD-9-CM code 245) showed significantly higher incidences in the type 1 diabetes cohort compared with the control cohort, with incidence rate ratios of 2.74, 6.95, 6.54, 16.07, respectively.ConclusionsFindings from this nationwide, population-based cohort study showed that the incidences of autoimmune thyroid disorders were significantly higher in Taiwanese children and adolescents with type 1 diabetes compared with those without the disease.

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Section: Discussionsupporting

confidence: 92%

Higher Risk of Thyroid Disorders in Young Patients with Type 1 Diabetes: A 12-Year Nationwide, Population-Based, Retrospective Cohort Study

Chang²,

Huang

et al. 2016

PLoS ONE

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“…The prevalence of thyroid autoantibodies is similar to the prevalence measured in the Western (Jeddah; 14%) 16 but higher than Central KSA (Riyadh; 8.1%). 17 The prevalence of T1DM reported in Jordan (9.2%), 18 Egypt (12%), 19 and Sudan (7.3%) 20 showed some variations, and a much higher prevalence was reported in studies of thyroid autoantibodies in T1DM children from Kuwait (24.6%), 21 and Libya (31.4%). 22 Global variations in prevalence have been shown in different studies.…”

Section: Discussionmentioning

confidence: 95%

Pattern of thyroid, celiac, and anti-cyclic citrullinated peptide autoantibodies coexistence with type 1 diabetes mellitus in patients from Southwestern Saudi Arabia

Al‐Hakami

2016

SMJ

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Objectives:To investigate the seroprevalence of coexisting autoantibodies among type 1 diabetes mellitus (T1DM) patients, and to look for possible correlations with age at diagnosis, diabetes duration, and glycemic control.Methods:This is a cross-sectional study conducted at Aseer Central Hospital, Abha, Kingdom of Saudi Arabia from March 2013 to June 2014. A total of 202 T1DM patients were screened for serum anti-thyroglobulin (TG), anti-thyroid peroxidase (TPO), anti-tissue transglutaminase (aTTG), anti-endomysial (EMA), and anti-cyclic citrullinated peptide (anti-CCP) antibodies along with glycated hemoglobin, and biometric data.Results:From the 202 T1DM patients (96 males, and 106 females) (mean age: 11.3 years), 33 (16.3%) were positive for thyroid autoantibodies. Specifically, 19 (9.4%) were positive for TG and 25 (12.8%) were positive for TPO, and 11 were double positive. There were 21 (10.4%) patients that showed a double positive for both aTTG-IgA and EMA, and only one case of T1DM was positive for anti-CCP. No significant correlations were noticed between the presence of autoantibodies and the age at diagnosis, diabetes duration, body mass index, and glycemic control.Conclusion:The prevalence of thyroid and celiac disease autoantibodies is high among T1DM patients, while anti-CCP remains low and might be weakly associated with T1DM in the southwestern region of Saudi Arabia. No significant correlation between the age at T1DM diagnosis, duration, and glycemic control, and the presence of autoantibodies was found.

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“…Corresponding with the previous studies, female predominance was the main finding in cases of positive thyroid antibodies. [4,10,18,19] However, the gender significance was controversial. [4,10,18,19] These differences in gender distribution of AITDs in T1DM patients might suggest different etiologic factors for developing antibodies related to AITD rather than T1DM, which represented solely a reflection of the predominant prevalence of thyroid diseases in females.…”

Section: Discussionmentioning

confidence: 99%

“…[3] Albeit, there were only 2 patients (16.6%) with abnormal TSH levels in our study, previous studies found an association between positive anti-TPO Ab in T1DM and abnormal TSH level. [4,10,14] In a meta-analysis, the prevalence of hypothyroidism among T1DM patients was twice as high as in the general population. [2] Also, Araujo et al [4] and Omar et al [10] found that patients with positive anti-TPO Ab had a higher proportion (approximately 50% of patients) of abnormal TSH.…”

Section: Discussionmentioning

confidence: 99%

Autoimmune thyroid disease in patients with type 1 diabetes mellites: A cross-sectional study from Syria

Alhaj Hazzaa,

Alsultan,

Kabalan

et al. 2024

Medicine

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The present study aimed to investigate the occurrence of autoimmune thyroid disease (AITD) in patients with type 1 diabetes mellitus (T1DM) by the presence of antithyroid peroxidase (anti-TPO Ab). Furthermore, we studied the relationship of clinical and thyroid ultrasound (US) characteristics with anti-TPO Ab. This cross-sectional study was performed in Al- Mowasat and Al-Assad University Hospitals from 2021 to 2023. Clinical, laboratories, and US features were collected and analyzed between positive compared to negative anti-TPO Ab. Of 76 patients, anti-TPO Ab was positive in 12 patients (15.7%) with female predominance [n = 10 (83.3%)]. Gender showed a difference between anti-TPO Ab groups (P = .026). DM duration showed a difference (P = .034), which was dominant for a group of positive anti-TPO Ab (median = 9). The age at DM diagnosis also showed a difference (P = .048), where most patients were under 10- years old at diagnosis [n = 39 (51.3%)] and the highest number of anti-TPO Ab positive patients [n = 7 (58.3%)] were in this age category. US findings showed a significant difference (P = .001). Regarding positive anti-TPO Ab patients, the most frequent US finding was immune pattern [7 (58.3%)], which was more common than in the negative group (12.5%). Age, hemoglobin A1c (HBA1c), and body mass index (BMI) did not present differences (P = .391, 0.692, and 0.453, respectively), however, all anti-TPO Ab positive patients were older than ten years and had HBA1c more than 8. Thyroid-stimulating hormone (TSH) was abnormal in 2 patients (16.6%) and both in anti-TPO Ab positive group. This study suggests that anti-TPO Ab appears in older patients and with longer MD duration. Also, data support using US and anti-TPO Ab as earlier markers for AITDs, and further recommending regular annual monitoring by US and anti-TPO Ab in all patients with T1DM for AITDs diagnosis, especially in females.

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Screening for thyroid disease among children and adolescents with type 1 diabetes mellitus

Cited by 8 publications

References 13 publications

Higher Risk of Thyroid Disorders in Young Patients with Type 1 Diabetes: A 12-Year Nationwide, Population-Based, Retrospective Cohort Study

Higher Risk of Thyroid Disorders in Young Patients with Type 1 Diabetes: A 12-Year Nationwide, Population-Based, Retrospective Cohort Study

Pattern of thyroid, celiac, and anti-cyclic citrullinated peptide autoantibodies coexistence with type 1 diabetes mellitus in patients from Southwestern Saudi Arabia

Autoimmune thyroid disease in patients with type 1 diabetes mellites: A cross-sectional study from Syria

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