Screening for toxic industrial chemicals using semipermeable membrane devices with rapid toxicity assays

Rogers, Kim R.; Harper, Sharon L.; Robertson, Gary

doi:10.1016/j.aca.2005.04.016

Cited by 19 publications

(6 citation statements)

References 15 publications

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“…These studies have typically expressed the potency of effect on a per sampler basis. Controlled laboratory studies assessing individual industrial chemicals accumulated in passive air samplers with cytotoxicity measures has also been reported [23]. A related field of study has assessed the teratogenicity [24] and AhR activity [25] of complex organic films, which form on outdoor windows in urban environments.…”

Section: Introductionmentioning

confidence: 99%

Assessing indoor air exposures using passive sampling with bioanalytical methods for estrogenicity and aryl hydrocarbon receptor activity

et al. 2009

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Passive air sampling was undertaken using polyurethane foam passive air samplers at three types of locations, including indoors (six offices) at buildings in the central business district (CBD) and at a private suburban home (indoor and outdoor) located 9 km from the CBD in Brisbane, Queensland, Australia. Estrogenic (E-SCREEN—MCF7-BOS) and aryl hydrocarbon receptor (AhR) (CAFLUX— H4G1.1c2) activity were assessed for samples collected from each of these locations. The samples were tested either as crude extracts (“untreated”) or were subjected to H2SO4 silica gel (“treated”) for each location in order to determine whether chemicals, which are not resistant to this treatment like polycyclic aromatic hydrocarbons, potentially account for the observed activity. In most cases, H2SO4 treatment resulted in a statistically significant reduction of potency for both endpoints, suggesting that chemicals less resistant to treatment may be responsible for much of the detected biological activity in these locations. Estrogenic potency measurements (<0.22–185 pg m−3) were highest in the indoor offices, followed by the indoor suburban home and finally the outdoor suburban home (which was not estrogenic). Total AhR activity for crude extracts (1.3–10 pg m−3) however was highest for the outdoor suburban home site. Levels of polycyclic aromatic hydrocarbons were monitored indoors and outdoors at the suburban home. At that location, polycyclic aromatic hydrocarbon air concentrations were on average approximately two times higher outdoor than indoor, while AhR potency was five times higher outdoor than indoor. No significant correlation was found between the estrogenic and AhR activity (P=0.88) for the sites in this study.

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Section: Introductionmentioning

confidence: 99%

Assessing indoor air exposures using passive sampling with bioanalytical methods for estrogenicity and aryl hydrocarbon receptor activity

et al. 2009

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“…Gutierrez et al (2002) applied the Microtox® system for screening wastewater discharges into wastewater treatment plants. The US Environmental Protection Agency (US-EPA) recommended Vibrio fischeri to study waters contaminated with toxic industrial chemicals (TICs) (Rogers et al 2005). Boluda et al (2002) tested the toxic effects of waters collected from irrigation channels in a Mediterranean wetland in Spain and found that Microtox® EC20 results were comparable with pollution indices gauged from analytical parameters.…”

Section: Introductionmentioning

confidence: 51%

The Microtox® biological test: Application in toxicity evaluation of surface waters and sediments in Poland

Niemirycz

Nichthauser

Staniszewska

et al. 2007

Oceanological and Hydrobiological Studies

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Research into the suitability of Microtox® for the evaluation of toxicity of surface waters and bottom sediments in Poland was conducted. Water bodies of various pollution levels were tested, including the Odra River and its tributaries, the Lower Vistula River, the Kashubian Lake District and the Gulf of Gdańsk, using a Microtox® Model 500 analyser (Microbics Corporation, USA). The majority of tested surface water samples were found to be apparently non-toxic. However, 75% of the bottom sediment samples were found to be highly toxic (EC50<2%). These results indicate that the Microtox® test is suitable for evaluating the toxicity of bottom sediments, in which pollutants tend to accumulate. It seems, however, that Microtox® lacks the sensitivity to be of use in analyzing water quality. The relationship between the toxicity of analysed sediments and their organic content was examined.

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“…Based on this study we have discovered that there are significant commonalities, but we do not know of any methodology that (i) provides detail of implementation for industry reproducibility and (ii) specifies the best practices that should be used in general, from the level of gas sensing up to decision-making in the case of this restricted area. As recommended in [15], newer frameworks need the extension of technologies to monitor complex toxic situations effectively. A real-time remote monitoring framework of WSNs and ambient intelligence based on temporal statistical methods governing decision-making for miners is developed for bridging the challenging gaps.…”

Section: Introductionmentioning

confidence: 99%

Towards Safety from Toxic Gases in Underground Mines Using Wireless Sensor Networks and Ambient Intelligence

Osunmakinde

2013

International Journal of Distributed Sensor Networks

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The growing number of fatalities among miners caused by toxic gases puts pressure on the mining industry; innovative approaches are required to improve underground miners' health. Toxic gases are very often released in underground mines and cannot easily be detected by human senses. This paper investigates the presence of the inherent types of toxic fumes in critical regions and their suspension and trends in the air and intends to generate knowledge that will assist in preventing miners from contracting diseases. The development of intelligent decision support systems is still in its infancy. Knowledge of how to make them profitable in improving miners' safety is largely lacking. An autonomous remote monitoring framework of wireless sensor networks, which integrates mobile sensing and Ohm's law, coupled with ambient intelligence governing decision-making for miners, is developed. The framework has been investigated in indoor scenarios and successfully deployed for real-life application in an aeronautic engine test cell environment, such as those typically found in underground mines. Useful demonstrations of the system were carried out to provide similar knowledge to safeguard engineers from the inhalation of toxic gases. This provides early warning for safety agents. The system has proven to be suitable for deployment in underground mines.

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Screening for toxic industrial chemicals using semipermeable membrane devices with rapid toxicity assays

Cited by 19 publications

References 15 publications

Assessing indoor air exposures using passive sampling with bioanalytical methods for estrogenicity and aryl hydrocarbon receptor activity

Assessing indoor air exposures using passive sampling with bioanalytical methods for estrogenicity and aryl hydrocarbon receptor activity

The Microtox® biological test: Application in toxicity evaluation of surface waters and sediments in Poland

Towards Safety from Toxic Gases in Underground Mines Using Wireless Sensor Networks and Ambient Intelligence

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