Screening Mammography

Bleyer, Archie

doi:10.1016/j.acra.2015.03.003

Cited by 15 publications

(4 citation statements)

References 48 publications

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“…3,6,7 Mounting evidence documents the harms of screening: frequent false positive results that lead to a cascade of testing, biopsies, anxiety, and overdiagnosis. [8][9][10] These harms increase with more frequent screening. While mammography screening reduces breast cancer mortality, 10 the absolute benefit is greater for women at higher risk of developing breast cancer.…”

Section: Introductionmentioning

confidence: 99%

“…[8][9][10] These harms increase with more frequent screening. While mammography screening reduces breast cancer mortality, 10 the absolute benefit is greater for women at higher risk of developing breast cancer. In contrast to a traditional Bonesize-fits-all^approach, risk-based screening would personalize recommendations in order to minimize harms and maximize benefits of screening.…”

Section: Introductionmentioning

confidence: 99%

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How Do Women View Risk-Based Mammography Screening? A Qualitative Study

Schifferdecker

Ozanne

et al. 2018

J GEN INTERN MED

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

How Do Women View Risk-Based Mammography Screening? A Qualitative Study

Schifferdecker

Ozanne

et al. 2018

J GEN INTERN MED

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“…With the disparate recommendations issued by organizations in the U.S. and elsewhere [ 25 – 29 ] and suggestions for personalized screening [ 30 – 32 ], we sought to examine the relationship between mammography screening frequency and mortality risk with consideration of age and estimated personal breast cancer risk category in the CTS, a large, well-characterized cohort of women with 20 years of follow-up. Since the biggest uncertainty and inconsistency between the recommendations, in addition to starting and stopping ages, pertains to biennial versus annual mammography, our analysis was focused on these two groups.…”

Section: Discussionmentioning

confidence: 99%

Mammography screening and mortality by risk status in the California teachers study

et al. 2021

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Background The debate continues among medical professionals regarding the frequency, starting age, and stopping age for mammography screening. Some experts suggest tailoring recommendations based on individuals’ personal breast cancer risk. Previous studies have not compared the impact of annual versus biennial mammography stratified by age group and risk category. The purpose of this study was to examine the relationship between mammography frequency and mortality by age group and risk category in the California Teachers Study. Methods Using data from study questionnaires from 93,438 women between the ages of 40 and 85 and linkages to the California Cancer Registry and other indices, overall and breast cancer-specific mortality by mammography frequency were estimated using multivariable Cox proportional hazards models, stratified by age group and risk category at baseline as determined by the Gail breast cancer risk model. Results During the follow-up period of 20 years, overall mortality risk was lower in women who had annual or biennial mammography compared to less frequent or no mammography in all age groups. Annual mammography was associated with lower overall mortality risk compared to biennial mammography among women age 50–85. This difference was especially apparent in women age 60–74, regardless of estimated Gail risk category at baseline. Breast cancer-specific mortality was lower among women who had annual mammography compared to biennial or less frequent mammography among women age 60–74, regardless of their baseline risk. Conclusions Our findings suggest that at least biennial mammography is beneficial to most women age 40–85 and that annual mammography is more beneficial than biennial mammography to most women age 50–85 in terms of overall mortality.

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“…Primary prevention of breast cancer by endocrine therapy has side effects and is not absolute, whereas prophylactic surgery is very effective [2] but socially and emotionally burdensome. Secondary prevention by early detection through mammographic screening can reduce mortality but at the cost of overdiagnosis and the burden of false-positive results [3,4]. Stratification of women according to the risk of developing breast cancer could provide a persuasive rationale for surgical intervention as well as improve the efficacy of risk-reduction and screening strategies by tailoring starting age and frequency [5, 6•].…”

Section: Introductionmentioning

confidence: 99%

Breast Cancer Susceptibility—Towards Individualised Risk Prediction

et al. 2019

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Purpose of Review Breast cancer is the most common cancer among females in developed countries. Strategies such as early detection by breast cancer screening can reduce the burden of disease but have disadvantages including overdiagnosis and increased cost. Stratification of women according to the risk of developing breast cancer, based on genetic and lifestyle risk factors, could improve risk-reduction and screening strategies by targeting those most likely to benefit. Recent Findings Breast cancer risk is partly determined by genetic factors including rare pathogenic variants in susceptibility genes and common low-risk variants. Other risk factors include alcohol use, smoking, reproductive factors, hormonal factors, family history, mammographic density, BMI, and body height. Ideally, all risk factors are combined into an individual breast cancer lifetime risk score, but this requires knowledge about their interactions as well as accurate effect sizes. A few risk models seem to be sufficiently developed to inform clinical risk management to minimise cancer risk of those at increased risk and avoid overtreatment of those at decreased risk. Summary In this review, we briefly summarise the breast cancer susceptibility factors and discuss avenues towards combining all these factors to create individual risk scores.

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Screening Mammography

Cited by 15 publications

References 48 publications

How Do Women View Risk-Based Mammography Screening? A Qualitative Study

How Do Women View Risk-Based Mammography Screening? A Qualitative Study

Mammography screening and mortality by risk status in the California teachers study

Breast Cancer Susceptibility—Towards Individualised Risk Prediction

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