2021
DOI: 10.1016/j.jpba.2020.113870
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Screening method of mildronate and over 300 doping agents by reversed-phase liquid chromatography-high resolution mass spectrometry

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Cited by 9 publications
(6 citation statements)
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“…Naujausi tyrimai rodo, kad su dilute-and-shoot procedūra susijęs SPE kartu su skysčių chromatografijaaukštos skiriamosios gebos masių spektrometrija (angl. liquid chromatography-high resolution mass spectrometry, LC-HRMS) vienu metu leidžia tiksliai identifikuoti šlapime esančias skirtingomis fizikinėmis ir cheminėmis savybėmis pasižyminčias medžiagas, tarp jų ir mildronatą [7]. Meldoniumas, kaip antiišeminį ir lengvą sedacinį poveikį turintis vaistas, plačiai vartojamas ir gyvulininkystės ūkiuose.…”
Section: Tyrimo Rezultataiunclassified
“…Naujausi tyrimai rodo, kad su dilute-and-shoot procedūra susijęs SPE kartu su skysčių chromatografijaaukštos skiriamosios gebos masių spektrometrija (angl. liquid chromatography-high resolution mass spectrometry, LC-HRMS) vienu metu leidžia tiksliai identifikuoti šlapime esančias skirtingomis fizikinėmis ir cheminėmis savybėmis pasižyminčias medžiagas, tarp jų ir mildronatą [7]. Meldoniumas, kaip antiišeminį ir lengvą sedacinį poveikį turintis vaistas, plačiai vartojamas ir gyvulininkystės ūkiuose.…”
Section: Tyrimo Rezultataiunclassified
“…While meldonium gained traction as a cardioprotective and anti-ischemic drug, its alleged performance-enhancing effects in athletes sparked controversy. In 2016, the World Anti-Doping Agency (WADA) added meldonium to its list of banned substances, citing concerns over its potential to increase endurance and aid in recovery [3]. This decision sparked a heated debate and led to several high-profile doping cases involving elite athletes.…”
Section: Introductionmentioning
confidence: 99%
“…Meldonium dihydrate is described in the European Pharmacopoeia [4,5]; for assay of meldonium, European Pharmacopoeia proposes acidimetric non-aqueous titration. By surveying the literature review, it was found that numerous methods have been reported for the determination of meldonium in biological fluids [6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21] and food products [22], but only a few methods have been reported for the determination of medonium in dosage forms medicines [23][24][25][26]. Meldonium dehydrates (Fig.…”
Section: Introductionmentioning
confidence: 99%