2023
DOI: 10.3390/molecules28186531
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Screening of Anti-Inflammatory Activity and Metabolomics Analysis of Endophytic Fungal Extracts; Identification and Characterization of Perylenequinones and Terpenoids from the Interesting Active Alternaria Endophyte

Rosella Spina,
Armelle Ropars,
Sihem Bouazzi
et al.

Abstract: Patients suffering from inflammatory chronic diseases are classically treated with anti-inflammatory drugs but unfortunately are highly susceptible to becoming resistant to their treatment. Finding new drugs is therefore crucial and urgent and research on endophytic fungi is a promising way forward. Endophytic fungi are microorganisms that colonize healthy plants and live within their intercellular tissues. They are able to produce a large variety of secondary metabolites while allowing their host to stay heal… Show more

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“…2 Along with enzymes like cyclooxygenases, they help in the release of prostaglandins, which are responsible for inflammatory responses. 3 The release of free radicals like nitric oxide and oxygen enhances oxidative stress and inflammatory responses. 4 Inflammatory diseases like arthritis, lupus or vasculitis are usually treated with steroidal anti-inflammatory and non-steroidal antiinflammatory drugs.…”
Section: Introductionmentioning
confidence: 99%
“…2 Along with enzymes like cyclooxygenases, they help in the release of prostaglandins, which are responsible for inflammatory responses. 3 The release of free radicals like nitric oxide and oxygen enhances oxidative stress and inflammatory responses. 4 Inflammatory diseases like arthritis, lupus or vasculitis are usually treated with steroidal anti-inflammatory and non-steroidal antiinflammatory drugs.…”
Section: Introductionmentioning
confidence: 99%