Screening of Antibacterial Activity In Vitro of<i>Eryngium creticum</i>

Pagoda plant (Clerodendrum paniculatum L.) is a medicinal plant that is widely distributed in ASEAN countries, including Indonesia. Pagoda plants are believed to have good pharmacological activity. In this study, the antibacterial activity of pagoda leaves was tested against Propionibacterium acnes. The method used in this research is the antibacterial activity test utilizing agar diffusion using paper discs to assess the inhibitory power of the test substance. The test groups used were water, ethyl acetate, and n-hexane fractions, with each divided into concentrations of 1, 3, 5, 10, 15, and 20%. The positive control used was Clindamycin, and the negative control used was dimethyl sulfoxide solution (DMSO). The results obtained with the highest inhibition value were clindamycin with an inhibition diameter of 28.70+0.15mm, then by a water fraction of 20% with an inhibitory diameter of 14.20+0.20mm. The study results concluded that the antibacterial activity of each fraction of the pagoda leaves was not vigorous in inhibiting the growth of Propionibacterium acnes bacteria.

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Antibacterial Activity of Water, Ethyl Acetate and n-Hexane Fractions of Pagoda leaves (Clerodendrum paniculatum L.) against Propionibacterium acnes

Hafiz

Novilia

Luthvia

et al. 2022

RJPT

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The Impact of Oregano Extract (Origanum vulgare) on Spleen Histomorphometry of the Colibacillosis Mouse Model

Amri

Suradinata

EPD

et al. 2023

RJPT

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Oregano leaves (Origanum vulgare) are potentially known as antibacterial agent. Colibacillosis is an infectious disease caused by Escherichia coli as the primary agent. Besides that, E.coli reported inducing various other systemic diseases that harm human health and the economy due to the massive transmission of bacteria in humans and livestock. This study investigated the potential use of oregano leaves to overcome the growth of E. coli in the colibacillosis mice model. Mice were infected with the E. coli, then administered with oregano leaf extract with increasing doses of 5mg/kg BW, 10mg/kg BW, and 20mg/kg BW. The spleen was collected and the histopathology and histomorphometry were analyzed. Administration of oregano leaf extract showed the potential to significantly reduce the rate of tissue damage (p<0.05) through the reduction of the size of white pulp, an indicator of the immune system's active resistance in overcoming pathogenic bacterial infections. It can be concluded that oregano extract improved the white pulp enlargement of spleen.

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Antibacterial activity of Rosa damascene petals mill extracts

Kaddar,

Hasan,

Al-diab

2023

RJPT

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Infectious diseases are one of the major common problems facing the world. Staphylococcus aureus and Escherichia coli are two causes of infectious diseases and are considered as multi drug resistance pathogens. There is a continuing need for the discovery of new agents to overcome antibiotic resistance. Plants used in traditional medicine comprise several components which can serve as alternative candidates. Of these components, phenolic compounds, a secondary plant metabolite, account for antibacterial activity of many plants. Rosa damascena, traditionally used for its several therapeutic properties, is highly rich of phenolic compounds. In this in vitro study, aqueous and ethanolic extracts of the Rosa damascene petals mill were prepared and the phenolic content was determined. The extracts were tested for antibacterial activity using the disk diffusion method and the broth microdilution method for MIC determination. The extracts were able to inhibit the growth of studying pathogens. Staphylococcus aureus was more sensitive to Rosa damascena aqueous extract with a MIC of 0.28×103µg/ml and inhibitory zone of 17.33±0.85mm. On the contrary, Escherichia coli was more sensitive to Rosa damascene ethanolic extract with a MIC of 0.2×103µg/ml and inhibitory zone of 16.33±1.15mm. The results suggest the antibacterial activity of the Rosa damascena mill.

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Screening of Antibacterial Activity In Vitro ofEryngium creticum

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Antibacterial Activity of Water, Ethyl Acetate and n-Hexane Fractions of Pagoda leaves (Clerodendrum paniculatum L.) against Propionibacterium acnes

Antibacterial Activity of Water, Ethyl Acetate and n-Hexane Fractions of Pagoda leaves (Clerodendrum paniculatum L.) against Propionibacterium acnes

The Impact of Oregano Extract (Origanum vulgare) on Spleen Histomorphometry of the Colibacillosis Mouse Model

Antibacterial activity of Rosa damascene petals mill extracts

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