Screening of Biomarkers in Liver Tissue after Bariatric Surgery Based on WGCNA and SVM-RFE Algorithms

Jiang, Yicheng; Wang, Yu; Chen, Shuai; Liu, Zhixin; Yang, Haojun; Jiao, Yuwen; Tang, Liming

doi:10.1155/2023/2970429

Cited by 8 publications

(2 citation statements)

References 75 publications

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“…Age and height were the second and third factors respectively. Whether the core values match or not is not an important factor for most people to reject the pursuit of Friends of the opposite sex [4][5][6].…”

Section: Figure 3 the Reasons For Rejecting The Pursuit Of The Opposi...mentioning

confidence: 99%

Current Situation on Making Friends Among Tsinghua Graduate Students

Wang

2023

EHSS

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Emotional friendship is an integral part of people's lives. The analysis of people's behavior of make friends can help us better understand the behavioral characteristics of a certain group. However, there is currently no relevant research on the special group of highly educated doctors students from Tsinghua University (THU). It is not clear whether this group is consistent with the general emotional friendship habits and friendship status in the society, and what characteristics are there. This study investigated 46 PhD students at Tsinghua University by means of questionnaires, including different grades, different genders, and different genders. The study found that PhD students in THU remained more positive and optimistic in the evaluation of self-state, and at the same time became more depressed in their willingness to make friends. This brought serious anxiety. The study also found that the participants prefer to make friends through offline activities rather than through targeted online activities. We will start with the questionnaire survey, analyze the problems in this area from the perspective of probability, and finally come up with some general guidelines for making friends. Finally, we can let the audience know the novel overview of Tsinghua doctors, the high-knowledge group, on the emotional aspect.

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Section: Figure 3 the Reasons For Rejecting The Pursuit Of The Opposi...mentioning

confidence: 99%

Current Situation on Making Friends Among Tsinghua Graduate Students

Wang

2023

EHSS

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“…Bioinformatics analysis technology plays a crucial role in the discovery of potential biomarkers and patterns in various research fields 7 . Among the many available analysis algorithms, the Weighted Gene Co-expression Network Analysis (WGCNA) algorithm has gained popularity among bioinformatics researchers due to its efficiency and accuracy.…”

Section: Introductionmentioning

confidence: 99%

Identification Potential Biomarker for Bladder Cancer using Feature Selection

Yu,

Dong,

Liu

et al. 2024

Preprint

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Background The aim of this study was to utilize machine learning techniques to identify biomarkers associated with the diagnosis of bladder cancer, providing valuable insights into its early pathogenesis and exploring their potential as prognostic markers and therapeutic targets. Methods Initially, we conducted a comparative analysis of the genomes between bladder cancer samples, focusing on identifying the most significant differences between the cancer group and the normal group. Next, we employed machine learning techniques for feature selection and identified a key gene by integrating ferroptosis-related genes into our analysis. Moreover, we integrated transcriptome data, somatic mutation data, and clinical data to perform comprehensive analyses, including functional enrichment analysis, tumor mutation load analysis, immune infiltration analysis, and pan-cancer analysis. These analyses aimed to elucidate the pathological relevance of the candidate genes. Furthermore, we constructed a ceRNA network to identify the genes and regulatory pathways associated with these candidate genes. Results We initially conducted screening using the Weighted Gene Co-expression Network Analysis and machine learning techniques, resulting in the identification of six candidate genes: NR4A1, PAMR1, CFD, RAI2, ALG3, and HAAO. Subsequently, by integrating data from the FerrDB database, we identified NR4A1 as a gene associated with ferroptosis. Additionally, our analysis revealed a correlation between the expression of NR4A1 and tumor mutations as well as immune infiltration in patients with bladder cancer. Conclusion Our data strongly suggest that NR4A1 could serve as a crucial prognostic biomarker for bladder cancer and may also play a role in the development of various other cancers.

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SIRT1/SREBPs-mediated regulation of lipid metabolism

Shen,

Kuang

et al. 2024

Pharmacological Research

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Screening of Biomarkers in Liver Tissue after Bariatric Surgery Based on WGCNA and SVM-RFE Algorithms

Cited by 8 publications

References 75 publications

Current Situation on Making Friends Among Tsinghua Graduate Students

Current Situation on Making Friends Among Tsinghua Graduate Students

Identification Potential Biomarker for Bladder Cancer using Feature Selection

SIRT1/SREBPs-mediated regulation of lipid metabolism

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