Screening of circulating microRNA biomarkers for prevalence of abdominal aortic aneurysm and aneurysm growth

Wanhainen, Anders; Mani, Kevin; Vorkapić, Emina; Basso, Rachel De; Björck, Martin; Länne, Toste; Wågsäter, Dick

doi:10.1016/j.atherosclerosis.2016.11.007

Cited by 50 publications

(46 citation statements)

References 21 publications

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“…No such differences were measured with the following genes: IL‐6 (n=466)31; Cystatin C (n=412)83; OPN (n=198)84; and 9p21 (n=741) 85. Of 20 investigated genetic markers, 10 were investigated by Wanhainen et al86 in 169 follow‐up patients (all concerning microRNA as marker for expansion), of which 8 markers demonstrated significant differences between slow and fast growing AAA.…”

Section: Resultsmentioning

confidence: 99%

Systematic Review of Circulating, Biomechanical, and Genetic Markers for the Prediction of Abdominal Aortic Aneurysm Growth and Rupture

Groeneveld

Meekel

Rubinstein

et al. 2018

JAHA

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BackgroundThe natural course of abdominal aortic aneurysms (AAA) is growth and rupture if left untreated. Numerous markers have been investigated; however, none are broadly acknowledged. Our aim was to identify potential prognostic markers for AAA growth and rupture.Methods and ResultsPotential circulating, biomechanical, and genetic markers were studied. A comprehensive search was conducted in PubMed, Embase, and Cochrane Library in February 2017, following Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA) guidelines. Study selection, data extraction, and methodological quality assessment were conducted by 2 independent researchers. Plausibility of markers was based on the amount of publications regarding the marker (more than 3), pooled sample size (more than 100), bias risk and statistical significance of the studies. Eighty‐two studies were included, which examined circulating (n=40), biomechanical (n=27), and genetic markers (n=7) and combinations of markers (n=8). Factors with an increased expansion risk included: AAA diameter (9 studies; n=1938; low bias risk), chlamydophila pneumonia (4 studies; n=311; medium bias risk), S‐elastin peptides (3 studies; n=205; medium bias risk), fluorodeoxyglucose uptake (3 studies; n=104; medium bias risk), and intraluminal thrombus size (5 studies; n=758; medium bias risk). Factors with an increased rupture risk rupture included: peak wall stress (9 studies; n=579; medium bias risk) and AAA diameter (8 studies; n=354; medium bias risk). No meta‐analysis was conducted because of clinical and methodological heterogeneity.ConclusionsWe identified 5 potential markers with a prognostic value for AAA growth and 2 for rupture. While interpreting these data, one must realize that conclusions are based on small sample sizes and clinical and methodological heterogeneity. Prospective and methodological consonant studies are strongly urged to further study these potential markers.

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Section: Resultsmentioning

confidence: 99%

Systematic Review of Circulating, Biomechanical, and Genetic Markers for the Prediction of Abdominal Aortic Aneurysm Growth and Rupture

Groeneveld

Meekel

Rubinstein

et al. 2018

JAHA

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“…Aortic aneurysm (AA) is an increasingly common and ultimately fatal rupture with no effective drug treatment, 187 are decreased. 191,193 However, miR-29b was up-regulated in human tissues from thoracic AA patients. 187 Moreover, serum miR-29c-3p…”

Section: Aneurysmmentioning

confidence: 96%

“…MiR‐24 is significantly decreased in both tissue and plasma of AAA patients and is inversely related to the size of the AAA 192. Recently, miR‐33a‐5p, let‐7i‐5, miR‐652‐3p and miR‐331‐3p are elevated in plasma of AAA patients compared with healthy controls, and miR‐192‐5p, miR‐10b‐5p, miR‐194‐5p, miR‐215‐5p, miR‐205‐5p, miR‐16‐5p, miR‐126, miR‐124a, miR‐155, miR‐223, miR‐29b, miR‐15a and miR‐15b are decreased 191, 193. However, miR‐29b was up‐regulated in human tissues from thoracic AA patients 187.…”

Section: Clinical Value Of Mirnas As New Biomarkers For Angiogenesis‐mentioning

confidence: 99%

The regulatory role of microRNAs in angiogenesis‐related diseases

Sun

Lei

et al. 2018

J Cellular Molecular Medi

120

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MicroRNAs (miRNAs) are small non‐coding RNAs that regulate gene expression at a post‐transcriptional level via either the degradation or translational repression of a target mRNA. They play an irreplaceable role in angiogenesis by regulating the proliferation, differentiation, apoptosis, migration and tube formation of angiogenesis‐related cells, which are indispensable for multitudinous physiological and pathological processes, especially for the occurrence and development of vascular diseases. Imbalance between the regulation of miRNAs and angiogenesis may cause many diseases such as cancer, cardiovascular disease, aneurysm, Kawasaki disease, aortic dissection, phlebothrombosis and diabetic microvascular complication. Therefore, it is important to explore the essential role of miRNAs in angiogenesis, which might help to uncover new and effective therapeutic strategies for vascular diseases. This review focuses on the interactions between miRNAs and angiogenesis, and miRNA‐based biomarkers in the diagnosis, treatment and prognosis of angiogenesis‐related diseases, providing an update on the understanding of the clinical value of miRNAs in targeting angiogenesis.

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“…However, aberrant expression of siRNA and miRNA also contributes to initiation and progression of AAA, and several studies reported that miRNA might be available as a biomarker to predispose AAA formation. 28) Therefore, a role of these molecules in the process Molecular Pharmacological Approach for Aneurysm of AAA formation has gained research interest, and modulation of their expression has been investigated in several experimental studies. siRNA and miRNA are a class of non-coding doublestranded RNA and induce posttranscriptional gene silencing in a sequence-specific fashion.…”

Section: Small Interfering Rna and Micrornamentioning

confidence: 99%

Molecular Pharmacological Approaches for Treating Abdominal Aortic Aneurysm

Miyake

Kurashiki

et al. 2019

Annals of Vascular Diseases

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Abdominal aortic aneurysm (AAA) is considered to be a potent life-threatening disorder in elderly individuals. Although many patients with a small AAA are detected during routine abdominal screening, there is no effective therapeutic option to prevent the progression or regression of AAA in the clinical setting. Recent advances in molecular biology have led to the identification of several important molecules, including microRNA and transcription factor, in the process of AAA formation. Regulation of these factors using nucleic acid drugs is expected to be a novel therapeutic option for AAA. Nucleic acid drugs can bind to target factors, mRNA, microRNA, and transcription factors in a sequence-specific fashion, resulting in a loss of function of the target molecule at the transcriptional or posttranscriptional level. Of note, inhibition of a transcription factor using a decoy strategy effectively suppresses experimental AAA formation, by regulating the expression of several genes associated with the disease progression. This review focuses on recent advances in molecular therapy of using nucleic acid drugs to treat AAA.

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Screening of circulating microRNA biomarkers for prevalence of abdominal aortic aneurysm and aneurysm growth

Abstract: This large cohort study identified several novel miRs with altered expression in AAA patients when compared to controls. Assessment of miR expression may offer an opportunity to predict disease progression and aneurysm growth.

Cited by 50 publications

References 21 publications

Systematic Review of Circulating, Biomechanical, and Genetic Markers for the Prediction of Abdominal Aortic Aneurysm Growth and Rupture

Systematic Review of Circulating, Biomechanical, and Genetic Markers for the Prediction of Abdominal Aortic Aneurysm Growth and Rupture

The regulatory role of microRNAs in angiogenesis‐related diseases

Molecular Pharmacological Approaches for Treating Abdominal Aortic Aneurysm

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