Screening of Critical Variables of Andrographis paniculata Extract Loaded onto Chitosan Microparticles
Melissa Yushan Ng,
Rosnani Hasham@Hisam,
Rahimah Sabtu
et al.
Abstract:Andrographis paniculata (AP) is a medicinal plant commonly found in Malaysia. However, the main challenges hindering its clinical values is its low bioavailability and solubility in aqueous environment which can be improved by incorporating it into a nanocarrier system. Therefore, this study was conducted to screen the critical variables involved in the development of AP extract-loaded chitosan microparticles. Nine formulations (coded as F1 to F9) at varying chitosan-to-tripolyphosphate (TPP) mass ratio (2:1, … Show more
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