Screening of
            <i>in vitro</i>
            cytotoxicity and antioxidant potential of selected endemic plants in Turkey

Kok, O. V. S.; Emsen, Bugrahan; Sürmen, Burak

doi:10.1080/16583655.2023.2217369

Cited by 3 publications

(1 citation statement)

References 57 publications

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“…In addition to the pharmacological activities of C. demersum, its antioxidant capacity also has an important place. The antioxidant capacity of plants is important because antioxidants are essential components that protect the body against damage from free radicals (Akbari et al 2022;Kok et al 2023). Free radicals, which are reactive molecules formed during normal cellular activities, are neutralized by antioxidants.…”

Section: Discussionmentioning

confidence: 99%

The efficacy of allelopathy of select lichens on antioxidant potential and multiplication of Ceratophyllum demersum L.

Tokgoz,

Emsen,

Dogan

2024

Preprint

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We aimed to investigate growth-promoting effect of Dermatocarpon miniatum and Parmelia saxatilis lichens on Ceratophyllum demersum propagated in vitro. Furthermore, we revealed antioxidant capacity variation in lichen-treated plant (allelopathic plant). C. demersum was subjected to methanol and water extracts from lichens, specifically D. miniatum and P. saxatilis. The most positive growth outcomes were witnessed when C. demersum was subjected to a methanol extract derived from P. saxatilis. We further examined DPPH scavenging and metal chelating activities, as well as total phenol and flavonoid contents, of the most robust allelopathic plants compared to control plants. Based on IC50 values, allelopathic plants exhibited greater efficacy in terms of DPPH scavenging and metal chelation activities in comparison with control. When we analyzed total phenols and flavonoids, both allelopathic plant samples, treated with both extracts, exhibited significantly higher levels (p < 0.05) compared to control. Methanol extract from allelopathic sample had maximum total phenol content (73.93 µg gallic acid equivalent/mg extract) and flavonoid content (66.26 µg quercetin equivalent/mg extract). In conclusion, this study will provide valuable input for future investigation in domain of plant development control and augmentation of biologically active substance propagation in plants, with a particular focus on utilizing P. saxatilis lichen.

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Section: Discussionmentioning

confidence: 99%

The efficacy of allelopathy of select lichens on antioxidant potential and multiplication of Ceratophyllum demersum L.

Tokgoz,

Emsen,

Dogan

2024

Preprint

Self Cite

View full text Add to dashboard Cite

show abstract

The efficacy of allelopathy of select lichens on antioxidant potential and proliferation of Ceratophyllum demersum L.

Tokgoz,

Emsen,

Dogan

2024

Plant Cell Tiss Organ Cult

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Differential cytotoxicity of methanol and water extracts from Bacopa monnieri (L.) Wettst and Ceratophyllum demersum L. on HepG2 and THLE2 cells

Arı,

Emsen,

Doğan

2024

Bulletin of Biotechnology

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This study evaluated the cytotoxic effects of methanol and water extracts from Bacopa monnieri (L.) Wettst and Ceratophyllum demersum L. on HepG2 (liver cancer) and THLE2 (normal liver) cell lines using XTT assay. The extracts were tested at concentration range of 12.5-400 µg/mL. In HepG2 cells, the water extract of B. monnieri at 400 µg/mL exhibited the highest cytotoxicity, reducing cell viability to 11.08%, which was statistically significant (p < 0.05) compared to other treatments. The methanol extract of C. demersum at 12.5 µg/mL had the least effect, maintaining 94.84% cell viability. For THLE2 cells, the water extract of B. monnieri (400 µg/mL) also showed the greatest reduction in cell viability (30.85%). The water extract of C. demersum at the same concentration resulted in similar viability (32.01%), with no significant statistical difference (p > 0.05). The lowest concentrations of methanol and water extracts of C. demersum showed minimal effects (97.55% and 97.74% viability, respectively). Median inhibitor concentration (IC50) analysis revealed that B. monnieri’s water extract was most effective, with IC50 values of 68.45 µg/mL for HepG2 and 127.05 µg/mL for THLE2 cells. In contrast, C. demersum’s methanol extract had the highest IC50 values (173.35 µg/mL and 228.46 µg/mL, respectively), indicating lower cytotoxicity. Heatmap and cluster analyses highlighted the selective cytotoxicity of C. demersum on cancer cells with minimal effects on normal cells, showing its potential for targeted cancer therapy.

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Screening of in vitro cytotoxicity and antioxidant potential of selected endemic plants in Turkey

Cited by 3 publications

References 57 publications

The efficacy of allelopathy of select lichens on antioxidant potential and multiplication of Ceratophyllum demersum L.

The efficacy of allelopathy of select lichens on antioxidant potential and multiplication of Ceratophyllum demersum L.

The efficacy of allelopathy of select lichens on antioxidant potential and proliferation of Ceratophyllum demersum L.

Differential cytotoxicity of methanol and water extracts from Bacopa monnieri (L.) Wettst and Ceratophyllum demersum L. on HepG2 and THLE2 cells

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