Screening of long non‐coding RNAs markers in plasma of children with chronic gastritis

Gu, Zhifeng; Shen, Huaying; Fu, Peng; Chen, Mei

doi:10.1016/j.cdtm.2020.01.001

Cited by 4 publications

(3 citation statements)

References 31 publications

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“…Besides various electronic and information technologies, the biological molecule is becoming an integral part of research on many other GI diseases. [ 57 , 58 , 59 ] Accordingly, we believe that it will also optimize the diagnosis of SNADETs. With the rapid advances in both “hardware” and “software,” the technological revolution will contribute to the increasing awareness and recognition of SNADETs.…”

Section: Endoscopic Diagnosis For Snadetsmentioning

confidence: 99%

Endoscopic diagnosis and treatment of superficial non-ampullary duodenal epithelial tumors: A review

Zhao,

Jiao,

Yang

et al. 2023

Journal of Translational Internal Medicine

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The surface of the small bowel mucosa is covered more than any other section of the digestive canal; however, the overall prevalence of small bowel tumors of the whole gastrointestinal tract is evidently low. Owing to the improvement in endoscopic techniques, the prevalence of small bowel tumors has increased across multiple countries, which is mainly due to an increase in duodenal tumors. Superficial non-ampullary duodenal epithelial tumors (SNADETs) are defined as tumors originating from the non-ampullary region in the duodenum that share similarities and discrepancies with their gastric and colorectal counterparts in the pathogenesis and clinicopathologic characteristics. To date, white light endoscopy (WLE) remains the cornerstone of endoscopic diagnosis for SNADETs. Besides, narrow-band imaging (NBI) techniques and magnifying endoscopy (ME) have been widely used in the clinic and endorsed by multiple guidelines and consensuses for SNADETs’ evaluation. Confocal laser endomicroscopy (CLE), endocytoscopy (ECS), and artificial intelligence (AI) are also up-and-coming methods, showing an exceptional value in the diagnosis of SNADETs. Similar to the endoscopic treatment for colorectal polyps, the choices for SNADETs mainly include cold snare polypectomy (CSP), endoscopic mucosal resection (EMR), endoscopic submucosal dissection (ESD), and laparoscopic endoscopic cooperative surgery (LECS). However, owing to the narrow lumen, rich vascularity, weak muscle layer, abundant Brunner’s gland, and the hardship of endoscope control, the duodenum ranks as one of the most dangerous operating areas in the digestive tract. Therefore, endoscopists must anticipate the difficulties in endoscopic maneuverability, remain aware of the increased risk of complications, and then select the appropriate treatment according to the advantages and disadvantages of each method.

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Section: Endoscopic Diagnosis For Snadetsmentioning

confidence: 99%

Endoscopic diagnosis and treatment of superficial non-ampullary duodenal epithelial tumors: A review

Zhao,

Jiao,

Yang

et al. 2023

Journal of Translational Internal Medicine

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“…Gastritis adalah peradangan selaput lambung yang disebabkan oleh kombinasi dari berbagai macam faktor, termasuk infeksi Helicobacter pylori (H. pylori) [1]. Kondisi tersebut dapat menjadi masalah akut atau kronis yang meningkatkan risiko pada kondisi lain, seperti radang lambung, perdarahan, atau kanker [2].…”

Section: Pendahuluanunclassified

Sistem Pakar Diagnosis Penyakit Gastritis Menggunakan Metode Certainty Factor Berbasis Android

Windarto

Isnanto²,

Setiawan³

2020

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<p>With the increasingly of the modern era, more and more diseases that arise due to human lifestyle and bacterial transmission. One of them is gastritis which occurs because of inflammation that occurs in the lining of the stomach which makes frequent pain in the stomach. From these problems, it is necessary to make an expert system application of gastritis disease which aims to provide information to the public to know the early symptoms of gastritis from an early age. The process of diagnose using the certainty factor method The methods in this study are data retrieval, system design, system making and system testing.From this research, it produces an expert system application that can diagnose the type of disease with the first test case 98.848%, the second test case 99.8464% and the third test case with the results of 99.99115264% correct and in accordance with expert knowledge. System testing is done by using black-box testing that shows the function of each unit of application 100% successful.</p>

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“…Given the high blood stability and detection sensitivity of lncRNAs in plasma compared with several traditional protein biomarkers, 29 circulating lncRNAs show promising roles as adjunct diagnostic/prognostic epigenetic biomarkers in several disorders, including inflammatory conditions. [30][31][32] In the last years, the circulatory MALAT1 expression profile was screened mainly in adults with sepsis. Pellegrina et al identified that deregulated MALAT1 expression might "contribute to gene expression changes associated with the poorer outcome of elderly patients with sepsis".…”

mentioning

confidence: 99%

Long Non-Coding RNAs ANRIL and HOTAIR Upregulation is Associated with Survival in Neonates with Sepsis in a Neonatal Intensive Care Unit

AbdAllah¹,

Ageeli²,

Shbeer³

et al. 2022

IJGM

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Background Recently, long non-coding RNAs (lncRNAs) have emerged as potential molecular biomarkers for sepsis. We aimed to profile the expression signature of three inflammation-related lncRNAs, MALAT1, ANRIL, and HHOTAIR, in the plasma of neonates with sepsis and correlate these signatures with the phenotype. Patients and Methods This case–control study included 124 neonates with sepsis (88 survivors/36 non-survivors) admitted to the neonatal ICU and 17 healthy neonates. The relative expressions were quantified by real-time PCR and correlated to the clinic-laboratory data. Results The three circulating lncRNAs were upregulated in the cases; the median levels were MALAT1 (median = 1.71, IQR: −0.5 to 3.27), ANRIL (median = 1.09, IQR: 0.89 to 1.30), and HOTAIR (median = 1.83, IQR: 1.44 to 2.41). Co-expression analysis showed that the three studied lncRNAs were directly correlated (all p -values <0.001). Overall and stratification by sex analyses revealed significantly higher levels of the three lncRNAs in non-survivors compared to the survivor group (all p -values <0.001). Principal component analysis showed a clear demarcation between the two study cohorts in males and females. Cohorts with upregulated ANRIL (hazard ratio; HR = 4.21, 95% CI = 1.15–10.4, p =0.030) and HOTAIR (HR = 2.49, 95% CI = 1.02–6.05, p =0.044) were at a higher risk of mortality. Conclusion Circulatory MALAT1, ANRIL, and HOTAIR were upregulated in neonatal sepsis, and the latter two may have the potential as prognostic biomarkers for survival in neonatal sepsis.

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Screening of long non‐coding RNAs markers in plasma of children with chronic gastritis

Cited by 4 publications

References 31 publications

Endoscopic diagnosis and treatment of superficial non-ampullary duodenal epithelial tumors: A review

Endoscopic diagnosis and treatment of superficial non-ampullary duodenal epithelial tumors: A review

Sistem Pakar Diagnosis Penyakit Gastritis Menggunakan Metode Certainty Factor Berbasis Android

Long Non-Coding RNAs ANRIL and HOTAIR Upregulation is Associated with Survival in Neonates with Sepsis in a Neonatal Intensive Care Unit

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