Screening of metabolic syndrome in children and adolescents

Gromnatska, N.M.; Lemishko, B.B.; Kulya, O; Pasichna, I; Beliusova, V.M.

doi:10.22141/2224-0721.18.2.2022.1153

Cited by 5 publications

(4 citation statements)

References 25 publications

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“…Дитяче ожиріння постає важливою медико-соціальною проблемою в Україні та за її межами з огляду на прогресуюче зростання його поширеності, наявності значного спектру коморбідних порушень [2,3,4], ризиків формування метаболічного синдрому (МС), основними критеріями якого у дитячому віці є абдомінальне ожиріння, інсулінорезистентність (ІР), дисліпідемія, підвищення артеріального тиску (IDF, 2007) [5,6]. Помилковим вважається ствердження про те, що МС -це проблема людей середнього та похилого віку, що підтверджується даними сучасних досліджень щодо його поширеності серед підліткового контингенту [7,8]. Дитяче ожиріння має своє коріння в генетичній сприйнятливості, на яку впливають фактори оточуючого середовища, в першу чергу, нераціональне харчування впродовж раннього дитинства та юності.…”

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Nutrition characteristics of Ukrainian Adolescents with Metabolic Syndrome

Strashok,

Buznytska

2023

CAHC

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One of the most important issues of modern medical science is the metabolic syndrome, the origins of which begin in childhood and adolescence. Purpose: To study the dietary peculiarities of Ukrainian adolescents with obesity and to identify the eating dis-orders on the background of metabolic syndrome. A survey on the nutrition of Ukrainian adolescents was conducted on the base of Institute of Children and Adolescents Health Care of the National Academy of Medical Sciences of Ukraine. As a result, a sample of 200 adolescents with obesity (age 14 – 18 years: 100 boys and 100 girls) was formed. Thus, irregular and unbalanced diet naturally causes digestive disorders, abnormalities in eating behavior and contributes to the formation of comorbid pathologies such as obesity and metabolic syndrome. Adolescents with obesity experienced sig-nificant zinc and magnesium deficiency in the body.

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Nutrition characteristics of Ukrainian Adolescents with Metabolic Syndrome

Strashok,

Buznytska

2023

CAHC

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“…У даний час кількість дітей, які страждають від ЦД2, у всьому світі щорічно збільшується [1,2]. Зростання числа підлітків із ЦД2 на тлі надмірної маси тіла й ожиріння зафіксовано і в Україні [3].…”

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Features of prediabetes management in adolescents with excessive body weight and obesity

Pankiv

2022

Mìžnarodnij endokrinologìčnij žurnal

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Background. Type 2 diabetes mellitus (T2DM) in childhood and adolescence is a relatively new disease. Until 1980, type 1 diabetes was considered the only form of diabetes in children and adolescents. Currently, the number of children suffering from type 2 diabetes is increasing annually worldwide. An increase in the number of adolescents with T2DM against the backdrop of overweight and obesity has also been recorded in Ukraine. The purpose of the study was to evaluate the effectiveness and safety of the dietary supplement Sakhnil as an additional complex of biologically active substances of plant origin in adolescents with impaired carbohydrate metabolism in the presence of overweight and obesity. Materials and methods. Eighteen adolescents with impaired glucose tolerance (IGT) against the background of overweight and obesity were under observation. The control group consisted of 20 obese adolescents without carbohydrate metabolism disorders. For patients with IGT, the criteria for inclusion in the study were: age of 15–18 years at the time of diagnosis, presence of hyperinsulinemia and insulin resistance (according to the Homeostatic Model Assessment for Insulin Resistance (HOMA)), overweight and obesity. Exclusion criteria were: type 1 diabetes and monogenic forms of diabetes, presence of ketonuria. Results. In the first and second groups, by the end of observation, there was no significant decrease in fasting glycemia, HbA1c level, as these indicators were within the reference values. However, at the end of the treatment, the first group with IGT showed a significant decrease in the level of glycemia 2 hours after the load. Therapy with the dietary supplement Sakhnil led to a significant decrease (by 23.1 %, p = 0.01) in glycemia 2 hours after the load, which was 7.06 ± 0.18 mmol/l. The difference between groups reached high reliability (p = 0.01). In the process of observation and treatment, there was a tendency to decrease the level of immunoreactive insulin (from 19.3 ± 3.1 μU/ml to 16.2 ± 2.7) and the value of the HOMA (from 3.1 ± 0.4 to 2.7 ± 0.4) in adolescents with IGT on the background of overweight and obesity. Conclusions. Dietary supplement Sakhnil is an effective remedy for the treatment of adolescents with impaired glucose tolerance. Sakhnil is well tolerated by patients, does not cause side effects.

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“…In recent years, an apparent increase in the prevalence of obesity, type 2 Diabetes Mellitus (DM), and Coronary Artery disease (CAD) has been observed. Cardiovascular diseases are the leading cause of death for approximately 2.2 million females and 1.9 million males in Europe annually [1,2].…”

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Peculiarities of Carbohydrate Metabolism Indicators, the Functional State of the Thyroid Gland in the Course Treatment With Telmisartan as Part of the Complex Therapy of Patients With Coronary Artery Disease, Type 2 Diabetes Mellitus on the Basis of Metab

Chmyr,

Dutka,

Svitlyk

et al. 2023

AML

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Aim. Is to study the characteristics of carbohydrate metabolism indicators, the functional state of the thyroid gland in the course treatment with Telmisartan as a part of the complex therapy of patients with Coronary Artery Disease, type 2 Diabetes Mellitus on the basis of Metabolic Syndrome. Materials and Methods. Research design. The first stage - formation of groups (the experimental group and the comparison group). The experimental group consisting of 27 patients (13 men and 14 women), taking Telmisartan 80 mg/day as a part of complex therapy (Metformin, Amlodipine, Rosuvastatin, Acetylsalicylic acid, and Nitroglycerin as needed). The comparison group consisting of 24 patients (12 men and 12 women) taking Ramipril, 5 mg/day in addition to the standard therapy, mentioned above. At the second stage, the patients were examined for carbohydrate metabolism and Thyroid-stimulating hormone and free Thyroxine. At the third stage, patients were prescribed the treatment for 1 month. The dose of metformin did not change during the study. Re-examination of hormones and carbohydrate metabolism parameters one month after the start of therapy was carried out at the fourth stage. The control group consisted of 40 practically healthy people (17 men and 23 women). The work involved researching the carbohydrate spectrum parameters as well as the followings hormones: free Thyroxine and Thyroid-stimulating hormone, control of blood pressure parameters. The Patients were examined twice, on the day of admission to inpatient treatment and after 1 month. According to the results of the obtained data, the studied groups were compared with each other, as well as with a group of healthy individuals. Results and Discussion. The study compared the dynamics of blood pressure parameters, indicators of carbohydrate metabolism, Thyroid-stimulating hormone and Free thyroxine in patients with Coronary Artery Disease and compensated type 2 Diabetes Mellitus on the basis of Metabolic Syndrome, depending on their intake of Telmisartan or Ramipril against the background of standard therapy, which included: Metformin, Amlodipine, Acetylsalicylic acid. In the group taking Telmisartan as part of complex treatment, a decrease in clinical manifestations of syntropic pathology was found, and the presence of positive dynamics of diastolic blood pressure indicators was noted even after 1 month of treatment. Patients experienced a decrease in the frequency of angina attacks, reduced shortness of breath, palpitations during exercise, headaches, dizziness, anxiety, improved attention and memory. The results of our study show taking Telmisartan as a part of complex therapy contributed to changes in the parameters of carbohydrate metabolism such as fasting blood glucose, insulin level, HOMA-IR index decreased significantly, which can be explained by a decrease in insulin resistance at addition Telmisartan to the complex treatment. In contrast to the mentioned above parameters, indicators of glycosylated hemoglobin after 1 month treatment did not change significantly, which can be explained by the insufficient duration of treatment. In the patients of the experimental group, it was found that the level of Thyroid-stimulating hormone significantly decreased during treatment with Telmisartan as part of complex therapy, in contrast to the comparison group, taking Ramipril at the same time. The level of free Thyroxine in patients with experimental group increased a month after start of therapy, while it remained unchanged in patients with comparison group. Conclusions. The effectiveness of correction of diastolic blood pressure parameters, the presence of peculiarities of changes in carbohydrate metabolism and thyroid functional state when Telmisartan is used as part of the complex therapy of patients with Coronary Artery Disease and compensated type 2 Diabetes Mellitus on the basis of Metabolic Syndrome. The use of Telmisartan as part of complex treatment reduces insulin resistance; helps to reduce the level of fasting blood glucose, values of the HOMA-IR index, as well as the amount of insulin in the blood. The use of Telmisartan in patients with Coronary Artery Disease and type 2 Diabetes Mellitus on the basis of Metabolic Syndrome aids in reducing the level of Thyroid-stimulating hormone and increase in free Thyroxine (within the reference values), confirming participation in the correction of metabolic changes.

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Screening of metabolic syndrome in children and adolescents

Cited by 5 publications

References 25 publications

Nutrition characteristics of Ukrainian Adolescents with Metabolic Syndrome

Nutrition characteristics of Ukrainian Adolescents with Metabolic Syndrome

Features of prediabetes management in adolescents with excessive body weight and obesity

Peculiarities of Carbohydrate Metabolism Indicators, the Functional State of the Thyroid Gland in the Course Treatment With Telmisartan as Part of the Complex Therapy of Patients With Coronary Artery Disease, Type 2 Diabetes Mellitus on the Basis of Metab

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