Screening of pharmacological uses of Urtica dioica and others benefits

Dhouibi, Raouia; Affes, Hanen; Salem, Maryem Ben; Hammami, S.; Sahnoun, Zouheir; Zeghal, Khaled Mounir; Ksouda, Kamilia

doi:10.1016/j.pbiomolbio.2019.05.008

Cited by 88 publications

(75 citation statements)

References 51 publications

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“…Urtica dioica L., commonly named stinging nettle, is an herbaceous perennial plant belonging to the family of Urticaceae and native of Eurasia. Its medicinal properties are well known, with a wide historical background of the use of its stems, leaves and roots [1]. Recent reviews by Kregiel et al [2] and Grauso et al [3] revealed the isolation by stinging nettle leaves of some important phenolic compounds such as caffeic acid, hydroxybenzoic acid, vanillic acid, coumaric acid, gentisic acid, protocatechuic acid, gallic acid, syringic acid, quinic acid and many caffeic and quinic acid derivatives, quercetin, catechin, pelargonidin and apigenin in both the glycosidic and non-glycosidic forms, performed by other authors.…”

Section: Introductionmentioning

confidence: 99%

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Effect of Drying Methods on Phenolic Compounds and Antioxidant Activity of Urtica dioica L. Leaves

Garcìa¹,

Ceccanti

Negro

et al. 2021

Horticulturae

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Stinging nettle (Urtica dioica) is a plant well known in traditional medicine for its many beneficial properties, but the lack of standardization regarding the product to offer to consumers limits its diffusion. To this end, drying appears to be a useful technique to offer a low-cost product that can be stored for long time, but the different drying procedures may give rise to end-products of very different quality as nutraceutical and antioxidant compounds. Nettle leaves have been dehydrated employing freeze-drying (FD), oven-drying (OD) or heat pump drying (HPD) and compared with fresh leaves following water extraction to emulate the use by final consumers. Results indicate that the best dehydration technique is HPD, which apparently gives rise to more than a doubling of total phenols and antioxidant activity in the extract compared to the water extract obtained from fresh leaves but a reduction in the level of ascorbic acid of about 39%. In addition, the content of some phenolic compounds is 10 to over a hundred times higher in the extract after HPD than that obtained from fresh samples. This confirms that the dehydration technique should be tuned in relation to the compounds of greatest interest or value.

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Section: Introductionmentioning

confidence: 99%

“…Understanding of the molecular mechanisms underlying the nutraceutical effects may open a new horizon for new therapeutic strategies [1].…”

Section: Introductionmentioning

confidence: 99%

Effect of Drying Methods on Phenolic Compounds and Antioxidant Activity of Urtica dioica L. Leaves

Garcìa¹,

Ceccanti

Negro

et al. 2021

Horticulturae

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“…В недавно опубликованном исследовании R. Dhouibi с соавт. [26] о различных фармакологических особенностях двудомной крапивы отмечается, что растение обладает вазодилатирующей и антитромбоцитарной активностью.…”

Section: Discussionunclassified

Decrease in Efficacy of Warfarin as a Result of Drug-Drug Interaction (Case Report)

Ватутин

Тарадин

Игнатенко

et al. 2020

Racionalʹnaâ farmakoterapiâ v kardiologii

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The one of the main aims in modern clinical pharmacology is to provide safe and effective therapy considering a frequent administration of several drugs having different drug-drug interactions. Warfarin belongs to the number of popular anticoagulants which along with its efficiency not infrequently alters anticoagulant characteristics when administered with other drugs and food products. A case of a decrease in the efficacy of warfarin in a patient with mitral stenosis while taking a combined choleretic drug is presented in the article. The components of this choleretic drug (dry animal bile, dry garlic extract, dry nettle extract, activated charcoal) could impair the absorption of warfarin, increase intestinal absorption of vitamin K, and have a negative effect on the anticoagulant effect of warfarin. Management of patients receiving anticoagulants should be performed in accordance with clinical recommendations. Prescription of drugs, including multicomponent ones, without proven efficacy, for such patients should be considering the potential drug interaction.

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“…Stinging nettle (Utrica dioica) has been used in various countries as traditional medicine for years. This plant has been reported to have therapeutic effects on cardiovascular, immunity, neuronal and digestive systems [36]. The agglutinin lectin is extracted from the rhizomes of the common stinging nettle.…”

Section: Utrica Dioica Agglutinin Lectinmentioning

confidence: 99%

Plants as a Prospective Source of Natural Anti-viral Compounds and Oral Vaccines Against COVID-19 Coronavirus

Yonesi¹,

Rezazadeh²

2020

Preprint

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The proposal of novel drugs and approaches for effective treatment of the novel coronavirus is a necessity after the quick outbreak of the disease. Since the commencement of the coronavirus spread, enormous efforts have been made to protect, alleviate and cure the disease, though no specific treatment has been approved. While there have been convincing results in the use of chemical drugs and interferon therapy, such therapeutic approaches have various drawbacks and lack the required performance for the treatment of the new coronavirus. Medicinal plant species can provide a solution as a source of natural antiviral compounds by the accumulation of secondary metabolites and lectins as well as acting as a platform to express the viral immunogenic proteins. This study reviews the advantages and the results of previous research for the treatment of the novel coronavirus disease and previous generations of similar coronaviruses. Several plant-derived anti coronavirus compounds have been nominated that could be targeted for further research due to the similarity of the coronavirus disease in 2003 and the current coronavirus. This review regards plant species such as Scutellaria baicalensis (Baikal skullcap), and Utrica dioica (Stinging nettle) as suitable candidates for the new coronavirus antiviral research. Furthermore, the use of plants such as Nicotiana tabacum (Tobacco) for the expression of the coronavirus viral antigens can be a target for the future vaccinal research of the new coronavirus due to the efficiency of expression and intrinsic antiviral properties.

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Screening of pharmacological uses of Urtica dioica and others benefits

Cited by 88 publications

References 51 publications

Effect of Drying Methods on Phenolic Compounds and Antioxidant Activity of Urtica dioica L. Leaves

Effect of Drying Methods on Phenolic Compounds and Antioxidant Activity of Urtica dioica L. Leaves

Decrease in Efficacy of Warfarin as a Result of Drug-Drug Interaction (Case Report)

Plants as a Prospective Source of Natural Anti-viral Compounds and Oral Vaccines Against COVID-19 Coronavirus

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