Screening of plasmonic properties of composed metal nanoparticles by combinatorial synthesis in micro-fluid segment sequences

Knauer, Andrea; Schneider, Steffen; Möller, F. A.; Csáki, Andrea; Fritzsche, Wolfgang; Köhler, J. Michael

doi:10.1016/j.cej.2012.10.008

Cited by 23 publications

(16 citation statements)

References 34 publications

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“…This peak can be attributed to surface plasmon resonance (Darroudi et al 2010 ). The red shift of plasmon resonance might be related to l -cysteine molecule on the surface of AgNPs (Knauer et al 2013 ). It should be noted that UV-Vis analysis did not confirm the presence of Ag 2 S.…”

Section: Resultsmentioning

confidence: 99%

Novel and effective synthesis protocol of AgNPs functionalized using L-cysteine as a potential drug carrier

Wojnicki

Luty–Błocho

Kotańska

et al. 2017

Naunyn-Schmiedeberg's Arch Pharmacol

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In this study, the protocol of a single-step l-cysteine functionalized silver nanoparticle synthesis was described. Particle size distribution was determined. The crystallinity and chemical properties were investigated using XRD, HR-TEM, and XPS methods. Acute toxicity and irritant properties of obtained nanoparticles were studied using mice and rats as an animal model. The results showed that thanks to the applied protocol, it was possible to synthesize silver nanoparticles with narrow particle size distribution. Moreover, the concentration of final product was extremely high in comparison to other known methods. These nanoparticles showed neither irritant properties nor acute toxicity.

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Section: Resultsmentioning

confidence: 99%

Novel and effective synthesis protocol of AgNPs functionalized using L-cysteine as a potential drug carrier

Wojnicki

Luty–Błocho

Kotańska

et al. 2017

Naunyn-Schmiedeberg's Arch Pharmacol

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“…Unfortunately, these particles are limited by their LSPR wavelength range above 520 nm. Triangular-shaped silver nanoparticles offer much higher scattering and absorption efficiency and additionally a spectral range tunable over the whole visible and infrared spectral range from 400 to 1200 nm [11] but the chemical synthesis of silver triangles is more complex compared to spheres [12][13][14]. In classical batch synthesis, the resulting nanoparticles are often polydisperse and their plasmonic properties, based on their geometry, are difficult to control.…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, with increasing complexity of the particle shape, more control during the synthesis is needed. Direct control of the synthesis parameters allows the immediate control during the synthesis to reach a homogeneous composition of the mixture [14]. This is the basis for the synthesis of nanoparticles with homogeneous particle size distribution and well-defined particle geometry.…”

Section: Introductionmentioning

confidence: 99%

High‐Throughput Synthesis of Uniform Silver Seed Particles by a Continuous Microfluidic Synthesis Platform

et al. 2015

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Controlled silver particle geometries require at least a synthesis in two steps which strongly differ in their reaction kinetics. For the first step, the very fast seed formation, chaotic advection-based micromixers are tested in combination with a batch reactor for the growth step. Nanoparticles with narrow size distribution and excellent shape uniformity can be prepared in large batches. To achieve a highly reproducible and homogeneous particle solution, a microfluidic system containing three different micromixers for optimal mixing of the chemical precursors is established, allowing stringent control of every synthesis step. The produced silver particles can be used as seeds for forming anisotropic particles. Their further potential is demonstrated by preparation of anisotropic silver triangles. The thus generated seed particles are better suited for growing to triangles than those from conventional batch synthesis.

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“…This technique is an important tool to realize experiments in the sub-microliter and nanoliter range that require complex concentration variations [12]. The segmented flow technique has been successfully introduced for a wide spread field of applications such as: (a) concentration-dependent synthesis of different types of nanoparticles [13]; (b) cultivation and susceptibility studies of microorganisms [14,15], in particular, for highly-resolved dose/response functions in micro-toxicology [16,17]; (c) for the screening of two-or three-dimensional concentration spaces and for realizing the principle of stochastic confinement for the search of rare microorganisms [18,19]; and (d) the synthesis of polymeric micro-rods [20], to name some exemplary applications.…”

Section: Introductionmentioning

confidence: 99%

Microfluidic Chamber Design for Controlled Droplet Expansion and Coalescence

et al. 2020

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The defined formation and expansion of droplets are essential operations for droplet-based screening assays. The volumetric expansion of droplets causes a dilution of the ingredients. Dilution is required for the generation of concentration graduation which is mandatory for many different assay protocols. Here, we describe the design of a microfluidic operation unit based on a bypassed chamber and its operation modes. The different operation modes enable the defined formation of sub-µL droplets on the one hand and the expansion of low nL to sub-µL droplets by controlled coalescence on the other. In this way the chamber acts as fluidic interface between two fluidic network parts dimensioned for different droplet volumes. Hence, channel confined droplets of about 30–40 nL from the first network part were expanded to cannel confined droplets of about 500 to about 2500 nL in the second network part. Four different operation modes were realized: (a) flow rate independent droplet formation in a self-controlled way caused by the bypassed chamber design, (b) single droplet expansion mode, (c) multiple droplet expansion mode, and (d) multiple droplet coalescence mode. The last mode was used for the automated coalescence of 12 droplets of about 40 nL volume to produce a highly ordered output sequence with individual droplet volumes of about 500 nL volume. The experimental investigation confirmed a high tolerance of the developed chamber against the variation of key parameters of the dispersed-phase like salt content, pH value and fluid viscosity. The presented fluidic chamber provides a solution for the problem of bridging different droplet volumes in a fluidic network.

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Screening of plasmonic properties of composed metal nanoparticles by combinatorial synthesis in micro-fluid segment sequences

Cited by 23 publications

References 34 publications

Novel and effective synthesis protocol of AgNPs functionalized using L-cysteine as a potential drug carrier

Novel and effective synthesis protocol of AgNPs functionalized using L-cysteine as a potential drug carrier

High‐Throughput Synthesis of Uniform Silver Seed Particles by a Continuous Microfluidic Synthesis Platform

Microfluidic Chamber Design for Controlled Droplet Expansion and Coalescence

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