Screening of selected food and medicinal plant extracts for pancreatic lipase inhibition

Slanc, Petra; Doljak, Bojan; Kreft, Samo; Lunder, Mojca; Janeš, Damjan; Štrukelj, Borut

doi:10.1002/ptr.2718

Cited by 115 publications

(76 citation statements)

References 9 publications

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“…As previously reported, SDF and polyphenol have lipase-inhibiting activity (24,30). Slanc et al reported that methanol extracts from Pisum sativum inhibited pancreatic lipase activity in vitro, and the removal of polyphenol from the extract decreased its inhibitory activity to less than 40% of the control (31). All plant materials, in addition to peas, contain phenolics (13).…”

Section: Discussionmentioning

confidence: 87%

Hypolipidemic Effect of the Autoclaved Extract Prepared from Pea (<i>Pisum sativum</i> L.) Pods In Vivo and In Vitro

Inagaki

Nishimura

Iwata

et al. 2016

J Nutr Sci Vitaminol

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Summary By autoclaving, we obtained a polyphenol and dietary fiber from pea (Pisum sativum L.) pods in parallel without acid or alkali treatment or organic solvent extraction. Rats fed a high-sucrose (HS) diet containing 3% autoclaved extract (AE) for 4 wk exhibited significantly lower serum triglyceride and total cholesterol levels than rats fed a HS diet. AE and soluble dietary fiber (SDF) from AE exhibited pancreatic lipase inhibitory activity at 13.3 mg/mL in vitro. AE and insoluble dietary fiber (IDF) from AE adsorbed cholesterol. In total, 30% and 10% of a cholesterol micelle were significantly adsorbed by 2,000 mg of AE and 100 mg of IDF from AE in 7 mL, respectively. The amount of bifidobacteria in the cecum of the AE group was significantly increased compared with that in the HS group. These results suggest that AE has hypolipidemic, bifidogenic potential.

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Section: Discussionmentioning

confidence: 87%

Hypolipidemic Effect of the Autoclaved Extract Prepared from Pea (<i>Pisum sativum</i> L.) Pods In Vivo and In Vitro

Inagaki

Nishimura

Iwata

et al. 2016

J Nutr Sci Vitaminol

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“…Polyphenol extracts are able to decrease the blood levels of glucose, triglycerides, and LDL cholesterol, increase energy expenditure and fat oxidation, and reduce body weight and adiposity [75,76]. In fact, many polyphenols, including flavones, flavonols, tannins, and chalcones, have shown an inhibitory activity of PL [9,22]. Flavonoids are a type of plant secondary metabolites that are characterized as containing two or more aromatic rings, each bearing at least one aromatic hydroxyl and connected with a carbon bridge [76].…”

Section: Polyphenolsmentioning

confidence: 99%

“…Therefore, the correlation of a triterpene-rich diet and the beneficial effects of consuming a Mediterranean diet should be investigated in more detail [32]. These types of plant secondary metabolites are found to inhibit PL and, thus, may represent potential effective treatments for obesity and related disorders [9,22]. Aesculus turbinata: The Japanese horse chestnut (Aesculus turbinata) is a medicinal plant widely used in East Asia.…”

Section: Saponinsmentioning

confidence: 99%

“…Accompanying this antiobesity action, Orlistat is also able to modestly reduce blood pressure, improve oral glucose tolerance and prevent the onset of type 2 diabetes [20,21]. Now, extracts from hundreds of species of medicinal plants, vegetables, and fruits [22] as well as products from microorganisms [9], fungi [23] and marine algae [24] are being screened for potential lipase inhibitory activity. Ideally, these treatments will be viewed as adjuncts to behavioral and lifestyle changes aimed at maintenance of weight loss and improved health [8].…”

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confidence: 99%

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2011

Planta Med

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Introduction !Obesity is becoming one of the greatest threats to global health in this century, with more than 1.5 billion overweight adults and at least 400 million of clinically obese subjects [1]. Due to these increasing obesity rates, the World Health Organization (WHO) has prompted to consider it as the epidemic of XXI century and to promote strategies to prevent and control its progress [2]. The development of obesity is characterized by a chronic imbalance between energy intake and energy expenditure [3][4][5], and it is often ascribed to changing lifestyles and inadequate dietary habits [3]. Also, decreased energy expenditure is often associated with an inherited low basal metabolic rate, low energy cost of physical activity, and low capacity for fat oxidation [6]. To reduce body weight and adiposity, a change in lifestyle habits is still the crucial cornerstone [7]. Physical activity might be helpful in the prevention of obesity by elevating the average daily metabolic rate and increasing energy expenditure [3]. Unfortunately, this clinical approach is not long-term lasting, and weight regain is often seen. Drugs that prevent weight regain appear necessary in obesity treatment [7]. Thus, the development of natural products for the treatment of obesity is a challenging task, which can be launched faster and cheaper than conventional single-entity pharmaceuticals [8]. Many medicinal plants may provide safe, natural, and cost-effective alternatives to synthetic drugs [9,10]. Currently, one of the most important strategies in the treatment of obesity includes development of inhibitors of nutrient digestion and absorption. For example, acarbose is an antidiabetic drug that inhibits glycoside hydrolases, thus preventing the digestion of complex carbohydrates and decreasing postprandial hyperglycemia [11,12]. Similar compounds with alpha-amylase inhibiting activity that can be used for diabetes control are being isolated from different plants. The list includes valoneaic acid dilactone [13], obtained from banaba (Lagerstroemia speciosa), the ethanol extract obtained from chestnut astringent skin [14], or the purified pancreatic alpha-amylase inhibitor isolated from white beans (Phaseolus vulgaris), which is able to reduce glycemia in both nondiabetic and diabetic rats [15]. Abstract !Obesity is a multifactorial disease characterized by an excessive weight for height due to an enlarged fat deposition such as adipose tissue, which is attributed to a higher calorie intake than the energy expenditure. The key strategy to combat obesity is to prevent chronic positive impairments in the energy equation. However, it is often difficult to maintain energy balance, because many available foods are high-energy yielding, which is usually accompanied by low levels of physical activity. The pharmaceutical industry has invested many efforts in producing antiobesity drugs; but only a lipid digestion inhibitor obtained from an actinobacterium is currently approved and authorized in Europe for obesity treatment. This compound i...

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“…The success of orlistat encouraged the development of PL inhibitors as weight-reducing drugs. In new weight-reducing therapies with more potency or fewer side effects, several natural PL inhibitors, such as platycodin saponins, scabiosaponins, chikusetsusaponins, tea saponins, assamicain A, oolonghomobisflavan A, and oolonghomobisflavan B, have been identified as inhibitors of PL activity in vitro (de la Garza et al, 2011;Han et al, 1999Han et al, ,2005Roh & Jung, 2012;Slanc et al, 2009;Zhao & Kim, 2004;Zheng et al, 2004). However, the compounds are difficult to develop as antiobesity drugs because of limited sources.…”

Section: Introductionmentioning

confidence: 99%

Saponin-enriched sea cucumber extracts exhibit an antiobesity effect through inhibition of pancreatic lipase activity and upregulation of LXR-β signaling

Guo

Gao

Zhang

et al. 2015

Pharmaceutical Biology

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(2016) Saponin-enriched sea cucumber extracts exhibit an antiobesity effect through inhibition of pancreatic lipase activity and upregulation of LXR-β signaling, Pharmaceutical Biology, 54:8, 1312-1325, DOI: 10.3109/13880209.2015 Objective: The objective of this study is to investigate the antiobesity and lipid-lowering effects of sea cucumber extracts in in vitro and in vivo models and elucidate the mechanism of action of the extracts on obesity and dyslipidemia. Materials and methods: The 60% ethanol extracts from the body walls of 10 different sea cucumbers were investigated for the inhibition of pancreatic lipase (PL) activity in vitro. The optimal active extract (SC-3) was further chemically analyzed by LC-MS and UV. And 0.1% and 0.2% of SC-3 was mixed with a high-fat diet to treat C57/BL6 mice for 6 weeks or 2 weeks as preventive and therapeutic study. The body weight, serum, and liver lipid profile in the mice were investigated. Results: The crude extract of Pearsonothuria graeffei Semper (Holothuriidae) inhibited the PL activity by 36.44% of control at 0.5 mg/mL. SC-3 and echinoside A inhibited PL with an IC 50 value at 2.86 mg/ mL and 0.76 mM. 0.1% of SC-3 reduced the body weight (23.0 ± 0.62 versus 26.3 ± 0.76 g), the serum TC (2.46 ± 0.04 versus 2.83 ± 0.12 mmol/L), TG (0.19 ± 0.08 versus 0.40 ± 0.03 mmo/L), and LDL-c (0.48 ± 0.02 versus 0.51 ± 0.02 mmol/L), and liver TC (1.19 ± 0.17 versus 1.85 ± 0.13 mmol/mg) and TG (6.18 ± 0.92 versus 10.87 ± 0.97 mmol/mg) contents of the obese C57BL/six mice on a high-fat diet. Discussion and conclusion: Sea cucumber may be used for developing antiobesity and antihyperlipidemia drugs. ARTICLE HISTORY

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Screening of selected food and medicinal plant extracts for pancreatic lipase inhibition

Cited by 115 publications

References 9 publications

Hypolipidemic Effect of the Autoclaved Extract Prepared from Pea (<i>Pisum sativum</i> L.) Pods In Vivo and In Vitro

Hypolipidemic Effect of the Autoclaved Extract Prepared from Pea (<i>Pisum sativum</i> L.) Pods In Vivo and In Vitro

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Saponin-enriched sea cucumber extracts exhibit an antiobesity effect through inhibition of pancreatic lipase activity and upregulation of LXR-β signaling

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