Screening of Serum Protein Markers for Avascular Osteonecrosis of Femoral Head Differentially Expressed after Treatment with Yuanshi Shengmai Chenggu Tablets

Deng, Peng; Zeng, Jianchun; Li, Jie; Feng, Wenjun; Chen, Jinlun; Zeng, Yirong

doi:10.1155/2018/5692735

Cited by 8 publications

(6 citation statements)

References 36 publications

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“…Reference Collection 31 (Bujalska et al, 2006;Appari et al, 2009;Chen et al, 2011;Allegra et al, 2012;Ammerpohl et al, 2013;Zhu et al, 2015;Salami et al, 2019;Tanase-Nakao et al, 2019;Geng et al, 2020). Reference Collection 32 (Albers et al, 1984;Haffner et al, 1985;Holmquist et al, 1993;Gottsch et al, 2003;Zenkel et al, 2005;Flatscher-Bader and Wilce, 2006;Tew et al, 2007;Collins-Racie et al, 2009;Schäfer et al, 2009;Sun et al, 2013;Aregger et al, 2014;Hueging et al, 2015;Kliuchnikova et al, 2016;Starodubtseva et al, 2016;Soria et al, 2017;Deng et al, 2018;Forster et al, 2019;Ponnikorn et al, 2019;Liu et al, 2020). Reference Collection 33 (Bouma et al, 1988;Patel et al, 1995;Navarro et al, 1998Navarro et al, , 2004Suresh et al, 1998;Ong et al, 1999;Hu et al, 2001;Leung et al, 2004;Schröder et al, 2007;Søiland et al, 2009a,b;Ordóñez et al, 2012;Martínez-Pinilla et al, 2015;...…”

Section: Apod Systematic Review Reference Collectionsunclassified

The Lipocalin Apolipoprotein D Functional Portrait: A Systematic Review

Sánchez

Ganfornina

2021

Front. Physiol.

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Apolipoprotein D is a chordate gene early originated in the Lipocalin protein family. Among other features, regulation of its expression in a wide variety of disease conditions in humans, as apparently unrelated as neurodegeneration or breast cancer, have called for attention on this gene. Also, its presence in different tissues, from blood to brain, and different subcellular locations, from HDL lipoparticles to the interior of lysosomes or the surface of extracellular vesicles, poses an interesting challenge in deciphering its physiological function: Is ApoD a moonlighting protein, serving different roles in different cellular compartments, tissues, or organisms? Or does it have a unique biochemical mechanism of action that accounts for such apparently diverse roles in different physiological situations? To answer these questions, we have performed a systematic review of all primary publications where ApoD properties have been investigated in chordates. We conclude that ApoD ligand binding in the Lipocalin pocket, combined with an antioxidant activity performed at the rim of the pocket are properties sufficient to explain ApoD association with different lipid-based structures, where its physiological function is better described as lipid-management than by long-range lipid-transport. Controlling the redox state of these lipid structures in particular subcellular locations or extracellular structures, ApoD is able to modulate an enormous array of apparently diverse processes in the organism, both in health and disease. The new picture emerging from these data should help to put the physiological role of ApoD in new contexts and to inspire well-focused future research.

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Section: Apod Systematic Review Reference Collectionsunclassified

The Lipocalin Apolipoprotein D Functional Portrait: A Systematic Review

Sánchez

Ganfornina

2021

Front. Physiol.

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“…Both joint replacement therapy, represented by total hip arthroplasty, and hip‐preserving treatment, represented by core decompression, have made great progress 15, 16 . In mainland China, orthopaedic surgeons can also choose Chinese medicine as a treatment method for patients 17, 18 . Considerable experimental work has been done in this area 19–22 , and a large number of patients who received hip‐sparing therapy with integrated medicine achieved satisfactory results 23 .…”

Section: Discussionmentioning

confidence: 99%

Epidemiological Study Based on China Osteonecrosis of the Femoral Head Database

Tan

Zeng

et al. 2020

Orthopaedic Surgery

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Objective The aim of the present study was to reveal the case characteristics of osteonecrosis of the femoral head (ONFH) in Mainland China. Methods This cross‐sectional epidemiological study derived data for ONFH patients from July 2016 to December 2018 from the China Osteonecrosis of the Femoral Head Database (CONFHD). The derived data included gender, age, body mass index (BMI), height, occupation, region, and etiology of femoral head necrosis. A descriptive analysis was performed to summarize the epidemiological characteristics of the case data in the CONFHD. Results A total of 1844 ONFH patients (2945 hips) were included in this study, comprising 1302 men and 542 women. The age of patients ranged from 18 to 95 years, with a median of 50 years, and the male to female ratio was 2.4. Male patients are younger than female patients (48.26 ± 12.56 years old and 55.56 ± 14.94 years old, respectively). Among the 1844 patients (2945 hips), there were 528 (17.92%) hips at ARCO stage I, 941 (31.99%) hips at ARCO stage II, 873 (29.63%) hips at ARCO stage III, and 603 (20.46%) hips at ARCO stage IV. In the subclassification of ARCO stages I and II, the majority of cases were type C; type A comprised the majority in the subclassification of ARCO stage III. According to the Kellgren–Lawrence classification system, among the 603 ARCO stage IV hips, there were 178 (29.52%) grade 1 hips, 201 (33.34%) grade 2 hips, 176 (29.18%) grade 3 hips, and 48 (7.96%) grade 4 hips. Most were from three provinces: Henan (27.3%), Shanxi (13.9%), and Shandong (11.9%). Regarding BMI, 982 patients (53.25%) were overweight or obese. Among all patients, the largest proportion of patients engaged in level IV manual work. Of all the patients, there were 495 (26.84%) with steroid‐induced ONFH, 685 (37.15%) were alcoholics, and 290 (15.73%) had traumatic ONFH. The 495 patients with steroid‐induced ONFH included 278 men (56.16%) and 217 women (43.84 %), had a complete history of hormone use. Among the primary diseases, there were 195 cases (39.39%) of immune system diseases, followed by dermatological diseases, respiratory diseases, nephropathy, and other diseases. There were a total of 685 patients with alcoholic ONFH, 589 of these patients (85.99%) were men. A total of 188 (27.45%) patients had drunk alcohol for 6–10 years (comprising the highest proportion), and 280 patients (40.88%) consumed 3001–3500 mL of alcohol each week (the highest proportion). Conclusion Osteonecrosis of the femoral head most commonly occurs after the age of 40. Male patients have an earlier onset than female patients, and the number of male patients is approximately twice that of female patients. The BMI of patients was mainly in the overweight and obese range, and half of these patients engaged in level IV manual work. From the imaging findings, the numbers of hips at ARCO stages II and III were greatest, and the number at stage I was relatively small. Among all the causes of disease, alcohol, steroid use and trauma were the three most common reasons for ONFH.

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“…Both the joint replacement therapy of THA and the hip-preserving treatment of core decompression have make great progress 27,28 . In mainland China, orthopaedic surgeons can also choose Chinese herbal medicine as one of the treatment methods for patients 26,29 . However, accurate diagnosis of ONFH has not been studied as comprehensively as its treatment and few previous studies have reported the risk factors for the misdiagnosis of ONFH in a Chinese population.…”

Section: Discussionmentioning

confidence: 99%

Exploring the Risk Factors for the Misdiagnosis of Osteonecrosis of Femoral Head: A Case‐Control Study

Tan

Jia

et al. 2020

Orthopaedic Surgery

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The purpose of the present study was to evaluate the present situation and risk factors for the misdiagnosis of osteonecrosis of femoral head (ONFH), providing the basis for accurate diagnosis of ONFH. Methods: For this retrospective study, 1471 patients with ONFH were selected from the China Osteonecrosis of Femoral Head Database (CONFHD). These patients had been recruited between July 2016 and December 2018. According to whether or not they were misdiagnosed, the patients were divided into two groups, with 1168 cases (22-84 years old) included in the diagnosis group and 303 cases (21-80 years old) in the misdiagnosis group. Misdiagnosis was measured using the following criteria: (i) the patient had the same symptoms and signs, and the second diagnosis was not consistent with the initial diagnosis within 6 months; and (ii) the patient was admitted to a hospital participating in CONFHD and the previous diagnosis was inconsistent with the diagnosis given by the expert group. Comparisons of age, visual analogue scale for pain, and body mass index between the two groups were performed using a t-test. Gender, causes of ONFH, primary diseases requiring corticosteroids, methods of corticosteroid use, corticosteroid species, type of trauma, onset side of the disease, pain side, whether symptoms are hidden, and type of imaging examination at the initial visit were compared using the χ 2-test. Years of alcohol consumption, weekly alcohol consumption, and physician title at the initial visit were compared using a Mann-Whitney U-test. Furthermore, the statistically significant factors were evaluated using multiple regression analysis to investigate the risk factors of misdiagnosis. Results: A total of 303 patients (20.6%) were misdiagnosed: 118 cases were misdiagnosed as lumbar disc herniation, 86 cases as hip synovitis, 48 cases as hip osteoarthritis, 32 cases as rheumatoid arthritis, 11 cases as piriformis syndrome, 5 cases as sciatica, and 3 cases as soft-tissue injury. Whether symptoms are hidden

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Screening of Serum Protein Markers for Avascular Osteonecrosis of Femoral Head Differentially Expressed after Treatment with Yuanshi Shengmai Chenggu Tablets

Cited by 8 publications

References 36 publications

The Lipocalin Apolipoprotein D Functional Portrait: A Systematic Review

The Lipocalin Apolipoprotein D Functional Portrait: A Systematic Review

Epidemiological Study Based on China Osteonecrosis of the Femoral Head Database

Exploring the Risk Factors for the Misdiagnosis of Osteonecrosis of Femoral Head: A Case‐Control Study

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