2023
DOI: 10.1002/bmc.5686
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Screening of superior anti‐osteoporotic flavonoids from Epimedii Folium with dual effects of reversing iron overload and promoting osteogenesis

Jun Jiang,
Jinjin He,
Shichang Xiao
et al.

Abstract: Iron overload is a risk factor for postmenopausal osteoporosis (PMOP) and lowering iron levels to regulate the labile plasma iron is the preferred therapy. Icariin (ICA), baohuoside I (BHS) and icaritin (ICT) are three flavonoids obtained from Epimedii Folium that are efficient in facilitating osteogenesis. In this study, an active flavonoid with dual effects of reversing iron overload and promoting osteogenesis was screened based on pharmacokinetics, iron complexation properties and the potential to downregul… Show more

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Cited by 6 publications
(2 citation statements)
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“…plant, has adequate musculoskeletal permeability and iron complexing properties. It can also utilize unstable plasma iron to construct artificial iron pools that would re verse the iron overload and promote osteogenesis ( Jiang J. et al, 2023 ). Icaritin was hypothesized to act as a potential natural phytochelator in this experiment.…”
Section: Tcm Flavonoids Modulate Bone Homeostasismentioning
confidence: 99%
“…plant, has adequate musculoskeletal permeability and iron complexing properties. It can also utilize unstable plasma iron to construct artificial iron pools that would re verse the iron overload and promote osteogenesis ( Jiang J. et al, 2023 ). Icaritin was hypothesized to act as a potential natural phytochelator in this experiment.…”
Section: Tcm Flavonoids Modulate Bone Homeostasismentioning
confidence: 99%
“…The determination of turbidity is carried out using the results of emulsification time. The emulsion that has been obtained is measured absorption using a UV-VIS spectrophotometer at a wavelength of 650 nm with an aquadest blank (28).…”
Section: Turbidity Testmentioning
confidence: 99%