Screening of the NOS3 gene identifies the variants 894G/T, 1998C/G and 2479G/A to be associated with acute onset ischemic stroke in young Asian Indians

Akhter, Muhammad Saleem; Biswas, Arijit; Rashid, Hina; Devi, Luxmi; Behari, Madhuri; Saxena, Renu

doi:10.1016/j.jns.2014.06.025

Cited by 7 publications

(4 citation statements)

References 39 publications

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“…These findings are in agreement with several case-control studies. [10][11][12]31,32 Akhter et al 33 reported that lower levels of nitric oxide is associated with ischemic stroke, indicating that eNOS has a neuroprotective effect and play the role of endothelial dysfunction in ischemic stroke pathogenesis. Recently, meta-analyses have reported the significant association between eNOS 4a/b polymorphism and increased risk of ischemic stroke, particularly in Asian population rather than Caucasian population.…”

Section: Discussionmentioning

confidence: 99%

Clinical Relevance of MTHFR, eNOS, ACE, and ApoE Gene Polymorphisms and Serum Vitamin Profile among Malay Patients with Ischemic Stroke

Wei

Menon

et al. 2015

Journal of Stroke and Cerebrovascular Diseases

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Section: Discussionmentioning

confidence: 99%

Clinical Relevance of MTHFR, eNOS, ACE, and ApoE Gene Polymorphisms and Serum Vitamin Profile among Malay Patients with Ischemic Stroke

Wei

Menon

et al. 2015

Journal of Stroke and Cerebrovascular Diseases

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“…36 studies were screened, and 21 studies were excluded for various reasons. Ten other studies (da Costa Escobar Piccoli et al, 2012;Jang et al, 2013;Rah et al, 2013;Akhter et al, 2014;Kang et al, 2014;Özçelik et al, 2014;Ben Chaaben et al, 2015;Hung et al, 2019;Lee, 2019;Tsay et al, 2019) were also excluded because of unavailable genotype frequency. Six studies (Hao, Montiel and Huang, 2010;Yao et al, 2013;Guo, 2014;Zhao et al, 2014;Abedinzadeh et al, 2020;Akbar et al, 2022) were not included in the analysis because they were meta-analysis studies.…”

Section: Study Processingmentioning

confidence: 99%

Association between nitric oxide and cancer and stroke risk: A meta-analysis

Tualeka,

Jalaludin,

Gasana

et al. 2024

F1000Res

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Background Numerous case-control studies have been carried out to test the mechanism by which nitric oxide, specifically the polymorphism 894G>T in the eNOS gene, or endothelial nitric oxide synthase, raises the possibility of stroke and cancer. This meta-analysis aimed to describe the correlation between cancer and stroke risk with nitric oxide (eNOS 894G>T polymorphism). Methods A comprehensive search was conducted on various digital databases, including Science Direct, PubMed, and Google Scholar, for articles published between 2012-2023. All related studies were collected and analysed to observe the published results. Results The meta-analysis included a total of fifteen case-control studies. These studies involved 3,019 cases (2,013 cancer and 1,006 strokes) and 3,333 controls (2,187 to evaluate cancer risk and 1,146 to evaluate stroke risk) overall. This study found that the GG versus GT+TT genotype of eNOS 894G>T polymorphism was significantly positively correlated with cancer risk, indicating that there is an association between eNOS 894G>T polymorphisms and an increased risk of developing cancer. Additionally, The significance of this association was further attributed to the specific type of polymorphism involved, as well as the risk of stroke in the T versus G model, followed by TT versus GG+GT. Conclusions The eNOS 894G>T polymorphism showed a significant association with cancer and stroke risk. Specifically, the GT+TT model was associated with increased cancer risk compared to the GG model. This polymorphism also showed an association with stroke risk, with the T and TT models showing increased risk compared to the G and GG+GT models. These results suggest that the eNOS 894G>T polymorphism may be a potential risk factor for cancer and stroke.

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“…Several genes and polymorphisms have been associated with susceptibility to CVD by influencing risk factors such as blood pressure, and high-density lipoprotein and low-density lipoprotein cholesterol (HDL-C and LDL-C, respectively) and triglyceride (TG) levels. [1] The influence of a number of genetic variants on stroke [2,3] and myocardial infarction [1,4,5,6] has also been reported. The development of CVD, therefore, appears to have a polygenic basis.…”

Section: Introductionmentioning

confidence: 99%

Interplay of physical activity and genetic variants of the endothelial lipase on cardiovascular disease risk factors

et al. 2021

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Screening of the NOS3 gene identifies the variants 894G/T, 1998C/G and 2479G/A to be associated with acute onset ischemic stroke in young Asian Indians

Cited by 7 publications

References 39 publications

Clinical Relevance of MTHFR, eNOS, ACE, and ApoE Gene Polymorphisms and Serum Vitamin Profile among Malay Patients with Ischemic Stroke

Clinical Relevance of MTHFR, eNOS, ACE, and ApoE Gene Polymorphisms and Serum Vitamin Profile among Malay Patients with Ischemic Stroke

Association between nitric oxide and cancer and stroke risk: A meta-analysis

Interplay of physical activity and genetic variants of the endothelial lipase on cardiovascular disease risk factors

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