Screening of α-glucosidase inhibitors in tea by amino-functionalized mesoporous SBA-15 immobilized α-glucosidase microreactor

Fan, Xiangze; Wang, Xiaoge; Zhou, Danyang; Fan, Yiru; Liu, Wei; Hu, Wei‐Xiao; Li, Xiuhua; Zhu, Jing

doi:10.1016/j.micromeso.2023.112656

Cited by 7 publications

(3 citation statements)

References 41 publications

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“…In addition, the spectra of SBA and EXSBA show the highest intensity at 1061 cm -1 , indicating stretching vibrations of the Si-O bonds of the siloxanes that can overlap in nearby bands 39,40 . The spectra of SBA-15 before (SBA) and after loading (EXSBA) showed the characteristic bond bands of the spectra found in the literature for SBA-15 29,33,41 .…”

Section: Chemical Characterizationmentioning

confidence: 60%

TEOS Silane Film Modified with SBA-15 Loaded with Cocoa Husk Extract as Pretreatment of ASTM 1008 Steel

Silva,

Carrijo-Gonçalves,

Barreto

et al. 2024

Mat. Res.

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Research on eco-friendly methods led to the investigation of natural inhibitors and silane films modified with nanostructured mesoporous silica (SBA-15), a molecular sieve that can carry molecules with inhibitory properties. Combining natural extracts such as cocoa husk with SBA-15 aims to develop an enhanced silane-based pretreatment. This involves obtaining an alcoholic extract, and then mixing it with SBA-15 to modify the silane film. Different concentrations (1%, 2%, and 3%) of SBA-15 loaded with extract were prepared. Electrochemical tests, especially electrochemical impedance spectroscopy (EIS), in a 0.1 mol/L NaCl solution, revealed improved corrosion resistance with the tetraethylorthosilane (TEOS) film modified using 3% SBA-15 loaded with extract. Scanning electron microscopy showed the film and SBA-15 on the steel surface, while Fourier transform infrared spectroscopy identified functional groups characteristic of SBA-15, pure or loaded, and silane film. Therefore, it was possible to enhance the TEOS silane film by adding SBA-15 loaded with plant residue extract.

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Section: Chemical Characterizationmentioning

confidence: 60%

TEOS Silane Film Modified with SBA-15 Loaded with Cocoa Husk Extract as Pretreatment of ASTM 1008 Steel

Silva,

Carrijo-Gonçalves,

Barreto

et al. 2024

Mat. Res.

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“…The small-angle XRD diffraction was mainly used to characterize the mesoporous structure of SBA-15 and its derivatives as shown in the vignette of Figure 1b. The distinctive diffraction peaks were associated with SBA-15, specifically those at 0.89 , 1.55 , and 1.79 corresponding to the (100), (110), and (200) planes, 29 which exhibited a gradual reduction in intensity as the modification progressed, eventually reaching near extinction. This was mainly caused by the fact that Zn-ATMP and DOPO were immobilized in pore channels and on the surface of SBA-15.…”

Section: Characterizationmentioning

confidence: 99%

Construction of a hybrid flame retardant based on mesoporous silica for enhancing fire safety, smoke suppression, and mechanical properties of epoxy resins

Yue,

Shi,

Zheng

et al. 2024

J of Applied Polymer Sci

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In order to improve the fire safety of epoxy resins (EPs), the SBA‐15 based hybrid flame retardant (SNAZD) was synthesized via an organic–inorganic hybridization strategy of mesoporous silica SBA‐15. Relying on electrostatic interaction, the zinc amino‐tris‐(methylenephosphonate) (Zn‐ATMP) was successfully introduced into the pore channels of SBA‐15. Then, 9,10‐dihydro‐9‐oxa‐10‐phosphaphenanthrene‐10‐oxide (DOPO) was successfully loaded into the pores of SBA‐15 under vacuum. The results show that the EP composites with the 5%SNAZD sample (sample EP‐5%SNAZD) showed a LOI value of 30.9% and achieved the vertical burning V‐0 rating. In comparison to EP, the peak heat release rate, peak smoke production rate, and production rate of CO of EP‐3%SNAZD were reduced by 32.2%, 31.9%, and 20.0%, respectively. This is due to the presence of Si, P, N, and Zn elements in the SNAZD, which promoted the generation of a high yield of dense char residue and inhibited the release of toxic gasses. And the impact strength and flexural strength of EP‐1%SNAZD were increased by 19.5% and 15.6%, respectively, and the E' of EP‐5%SNAZD increased by 49.1% when compared with the neat EP. This work provides a general strategy for the design of mesoporous hybrid flame retardant and creates additional opportunities for applications of EP.

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“…Diabetes is a chronic metabolic disorder characterized by inadequate production or response to insulin, resulting in elevated glucose levels in the bloodstream. α-Glucosidase inhibitors have been extensively used in the treatment of patients with type II diabetes mellitus due to their ability to slow down carbohydrate digestion and absorption [5], resulting in reduced blood glucose concentration and controlled postprandial blood glucose levels in diabetic patients [6,7]. However, the current medications available on the market for dia-betes treatment, such as acarbose, miglitol, and voglibose, often elicit gastrointestinal side effects [8,9].…”

Section: Introductionmentioning

confidence: 99%

Fast screening of α‐glucosidase inhibitors from Ginkgo biloba leaf by using α‐glucosidase immobilized on magnetic metal‐organic framework

Li,

Liu,

Wang

et al. 2024

J of Separation Science

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In this study, a ligand fishing method for the screening of α‐glucosidase inhibitors from Ginkgo biloba leaf was established for the first time using α‐glucosidase immobilized on the magnetic metal‐organic framework. The immobilized α‐glucosidase exhibited enhanced resistance to temperature and pH, as well as good thermal stability and reusability. Two ligands, namely quercitrin and quercetin, were screened from Ginkgo biloba leaf and identified by ultra‐high performance liquid chromatography‐tandem mass spectrometry. The half‐maximal inhibitory concentration values for quercitrin and quercetin were determined to be 105.69 ± 0.39 and 83.49 ± 0.79 µM, respectively. Molecular docking further confirmed the strong inhibitory effect of these two ligands. The proposed approach in this study demonstrates exceptional efficiency in the screening of α‐glucosidase inhibitors from complex natural medicinal plants, thus exhibiting significant potential for the discovery of antidiabetic compounds.

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Screening of α-glucosidase inhibitors in tea by amino-functionalized mesoporous SBA-15 immobilized α-glucosidase microreactor

Cited by 7 publications

References 41 publications

TEOS Silane Film Modified with SBA-15 Loaded with Cocoa Husk Extract as Pretreatment of ASTM 1008 Steel

TEOS Silane Film Modified with SBA-15 Loaded with Cocoa Husk Extract as Pretreatment of ASTM 1008 Steel

Construction of a hybrid flame retardant based on mesoporous silica for enhancing fire safety, smoke suppression, and mechanical properties of epoxy resins

Fast screening of α‐glucosidase inhibitors from Ginkgo biloba leaf by using α‐glucosidase immobilized on magnetic metal‐organic framework

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