Screening patients with tuberculosis for diabetes mellitus in Gujarat, India

Dave, Paresh; Shah, Ajay; Chauhan, Monica; Kumar, Ajay M. V.; Harries, Anthony; Malhotra, Sumit; Pujara, Kirit; Patel, Priyanka; Mane, Makarand; Thakkar, Aarti; Bharaswadkar, Sandeep; Sharath, B. N.; Achanta, Shanta

doi:10.5588/pha.13.0027

Cited by 33 publications

(28 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The prevalence of pre-diabetes in our study was 11.5%.This finding is higher than the study done in China (7.8%) [ 25 ], Gujarat-India (7%) [ 26 ], Saluru–India (8.5%) [ 27 ] and Kolar–India (3.1%) [ 28 ] but lower than the study finding from Gondar (29.6%), Addis Ababa-Ethiopia (26.7%) and Tamil Nadu–India (24.5%) [ 18 – 19 , 29 ].This finding may indicate an increased risk of DM in the future in Ethiopia. Lifestyle change and health promotion activity may delay the onset of DM [ 25 , 27 ].…”

Section: Discussioncontrasting

confidence: 70%

Prevalence and Associated Factors of Diabetes Mellitus among Tuberculosis Patients in South-Eastern Amhara Region, Ethiopia: A Cross Sectional Study

2016

View full text Add to dashboard Cite

BackgroundThe association between diabetes mellitus (DM) and tuberculosis (TB) is re-emerging worldwide. Recently, the prevalence of DM is increasing in resource poor countries where TB is of high burden. The objective of the current study was to determine the prevalence and analyze associated factors of TB and DM comorbidity in South-Eastern Amhara Region, Ethiopia.MethodsThis was a facility based cross-sectional study. All newly diagnosed TB patients attending selected health facilities in the study area were consecutively screened for DM. DM was diagnosed based on the World Health Organization diagnostic criteria. A pre-tested semi-structured questionnaire was used to collect socio-demographic, lifestyles and clinical data. Logistic regression analysis was performed to identify factors associated with TB and DM comorbidity.ResultAmong a total of 1314 patients who participated in the study, the prevalence of DM was estimated at 109 (8.3%). Being female [odds ratio (OR) 1.70; 95% confidence interval (CI) (1.10–2.62)], patients age [41–64 years (OR 3.35; 95% CI (2.01–5.57), 65–89 years (OR 3.18; 95% CI (1.52–6.64)], being a pulmonary TB case [(OR 1.69; 95% CI 1.09–2.63)] and having a family history of DM [(OR 4.54; 95% CI (2.36–8.73)] were associated factors identified with TB and DM comorbidity.ConclusionThe prevalence of DM among TB patients in South-Eastern Amahra Region is high. Routine screening of TB patients for DM is recommended in the study area.

show abstract

Section: Discussioncontrasting

confidence: 70%

Prevalence and Associated Factors of Diabetes Mellitus among Tuberculosis Patients in South-Eastern Amhara Region, Ethiopia: A Cross Sectional Study

2016

View full text Add to dashboard Cite

show abstract

“…Despite these limitations, our results are generalizable to other TB populations in India, particularly those with a similar age range. 11,13,14 …”

Section: Discussionmentioning

confidence: 99%

Prevalence of dysglycemia and clinical presentation of pulmonary tuberculosis in Western India

Mave

Meshram

Lokhande

et al. 2017

int j tuberc lung dis

View full text Add to dashboard Cite

SUMMARY SETTING: Pune, India. OBJECTIVES: To estimate the prevalence and risk factors of pre-diabetes mellitus (DM) and DM, and its associations with the clinical presentation of tuberculosis (TB). DESIGN: Screening for DM was conducted among adults (age ⩾ 18 years) with confirmed TB between December 2013 and January 2017. We used multinomial regression to evaluate the risk factors for pre-DM (glycated hemoglobin [HbA1c] ⩾ 5.7–6.5% or fasting glucose 100–125 mg/dl) and DM (HbA1c ⩾ 6.5% or fasting glucose ⩾ 126 mg/dl or random blood glucose > 200 mg/dl or self-reported DM history/treatment) and the association of dysglycemia with the severity of TB disease. RESULTS: Among 1793 participants screened, 890 (50%) had microbiologically confirmed TB. Of these, 33% had pre-DM and 18% had DM; 41% were newly diagnosed. The median HbA1c level among newly diagnosed DM was 7.0% vs. 10.3% among known DM (P < 0.001). DM (adjusted OR [aOR] 4.94, 95%CI 2.33–10.48) and each per cent increase in HbA1c (aOR 1.42, 95%CI 1.01–2.01) was associated with >1+smear grade or ⩽9 days to TB detection. CONCLUSION: Over half of newly diagnosed TB patients had DM or pre-DM. DM and increasing dysglycemia was associated with higher bacterial burden at TB diagnosis, potentially indicating a higher risk of TB transmission to close contacts.

show abstract

“…23,24 DM prevalence rates ranging from 1.9% to 35% have been reported by screening for DM among TB patients across different regions of India. [25][26][27] The higher values were reported from regions with higher prevalence of DM. Many of the patients were newly diagnosed as a result of expansion of medical care related anti tubercular treatment.…”

Section: Discussionmentioning

confidence: 99%

Bi-directional screening of tuberculosis patients for type 2 diabetes mellitus and diabetes patients for tuberculosis in Bhubaneswar, Odisha

Das

Bhuyan

et al. 2017

Int J Community Med Public Health

View full text Add to dashboard Cite

Background: The aim of the study was to assess the feasibility and results of screening diabetes mellitus (DM) patients for tuberculosis (TB) and TB patients for DM within the routine health care settings. Methods: Prospective observational study was carried out within the Diabetes Centre and TB division from June, 2014 to June, 2016. The screening for active TB in DM and DM in TB patients is followed as per the guidelines of the revised national tuberculosis control programme and national programmes in India. Results: 350 patients with active TB disease were screened for diabetes during the study period. Among the TB patients, 28% patients were having pre-diabetes and 17% patients were having diabetes. Both the conditions, pre-Diabetes or diabetes, were more common among males, married patients, advancing age, having less education, no specific job, sedentary life style, smoking / drinking, living in crowded areas, poor living conditions as well as unhygienic environment. 350 patients with diabetes were screened for TB in which 8 (2.2%) patients found to have TB. The various socio-demographic factors appeared to be significant factors. RBG levels, cholesterol and triglycerides were raised among most of the diabetes patients. Age, male gender and Cat-I status appeared to be significant factors among patients having both conditions The incidence of TB among T2DM patients is less than that reported from other regions. Conclusions: Bi-directional screening of TB patients for DM and DM patients for active TB leads to earlier detection of DM as well as TB, better TB-specific treatment, favourable outcome for TB as well as DM and prevention of DM complications. This study is the first of its kind in this State.

show abstract

Screening patients with tuberculosis for diabetes mellitus in Gujarat, India

Abstract: This pilot project shows that it is feasible and valuable to screen patients with TB for DM in a routine setting, resulting in earlier identification of DM and opportunities for better management of comorbidity.

Cited by 33 publications

References 14 publications

Prevalence and Associated Factors of Diabetes Mellitus among Tuberculosis Patients in South-Eastern Amhara Region, Ethiopia: A Cross Sectional Study

Prevalence and Associated Factors of Diabetes Mellitus among Tuberculosis Patients in South-Eastern Amhara Region, Ethiopia: A Cross Sectional Study

Prevalence of dysglycemia and clinical presentation of pulmonary tuberculosis in Western India

Bi-directional screening of tuberculosis patients for type 2 diabetes mellitus and diabetes patients for tuberculosis in Bhubaneswar, Odisha

Contact Info

Product

Resources

About