Screening post-menopausal women for bone mineral level by bioelectrical impedance spectroscopy of dominant arm

Abstract

Dominant arm bioimpedance spectroscopy (BIS) and lumbar and hip dual energy X-ray absorptiometry (DXA) measurements were conducted simultaneously on 48 post-menopausal women, aged between 43 and 86 years, with no hip or arm fracture history at Department of Radiology of Istanbul University Cerrahpasa Hospital. According to lumbar DXA results, 21 women were classified as normal, 22 as osteopenia and 5 as osteoporosis; whereas hip DXA results classified 30 women as normal, 15 as osteopenia and 3 as osteoporosis. Only 26 participants had identical lumbar and hip bone mineral density (BMD) diagnostic results. Dominant arm characteristic frequencies of normal subjects were statistically significantly different from osteoporotic subjects based on both lumbar (p < 0.005) and hip classification groups (p < 0.001). Hip and lumbar spine DXA BMD values were significantly correlated (r = 0.55, p < 0.005). The dominant arm BIS characteristic frequency, considered as the single predictor in earlier diagnosis of osteoporosis, was found negatively correlated with DXA measurements for both hip and lumbar spine regions. The Spearman rank correlation coefficient of BIS values with the hip DXA values (r = -0.53, p < 0.001) was higher than that of lumbar spine (r = -0.37, p < 0.001). In receiver operating characteristic (ROC) curve analysis, the best discrimination of dominant arm characteristic frequency was made between normal and osteoporotic subjects based on the hip subgroups (p < 0.001). Both lumbar bone mineral content (BMC) (r = -0.47, p < 0.001) and hip BMC (r = -0.4340, p < 0.005) were statistically significantly correlated with dominant arm characteristic frequency.

Impedance Analysis to Evaluate Nutritional Status in Physiological and Pathological Conditions

“…This provided a new biomarker for BMD using BIVA [ 51 ]. Accordingly, previous studies have already demonstrated the existence of a correlation between BIA and BMD [ 53 , 54 ].…”

“…In older adults is documented a decrease in bone mineral density (BMD) [ 51 ], the parameter for determining the severity of osteoporosis, which is defined as a low bone mass associated with the appearance of microarchitectural changes in the bone [ 52 ]. In addition to aging, postmenopausal osteoporosis also results in a change in mineral bone density due to a loss of trabecular bone as a result of changes in body composition and hormone levels [ 53 ].…”

Comparison of whole body bone mineral density measurement between dual-energy X-ray absorptiometry and novel foot-to-foot bioelectrical impedance analyzer

“…Recent studies have indicated that bioelectrical impedance vector analysis (BIVA), its phase angle (PhA), the whole body, spine, and pr of middle-aged and elderly people. The BMD of the proximal femur has a certain correlation, especially in the lower PhA, which is related to osteoporosis [11][12][13] . Bioelectrical impedance analysis (BIA) is a noninvasive method for estimating the composition of the body according to the degree of resistance of the body tissue by passing a low-intensity current through the body.…”