Screening retreatment tuberculosis patients for drug resistance in mid-west Nepal: how well are we doing?

Tharu, M. B.; Harries, Anthony; Goel, Sonu; Srivastava, Shashikant; Kumar, Ajay M. V.; Adhikari, Madhuchhanda; Shrestha, Bhawana; Maharjan, Bhagwan; Khadka, Hari Bahadur

doi:10.5588/pha.13.0104

Cited by 6 publications

(7 citation statements)

References 8 publications

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“…According to our study findings, one-quarter of the patients did not achieve this goal of DST. The proportion of previously treated patients in whom DST has been performed largely varies according to the study settings, from less than 10% in the midwest Nepal to 91% in Sri Lanka [ 14 , 15 ].…”

Section: Discussionmentioning

confidence: 99%

Characteristics and Treatment Outcomes of Retreatment Tuberculosis Patients in Benin

Adè

Adjibode

Wachinou

et al. 2016

Tuberculosis Research and Treatment

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Objective. To determine among retreatment tuberculosis patients in Benin baseline characteristics, culture, and drug sensitivity testing (DST) results and treatment outcomes. Materials and Methods. A retrospective national cohort study of all retreatment tuberculosis patients in Benin in 2013 using registers and treatment cards. Results. Of 3957 patients with tuberculosis, 241 (6%) were retreatment cases. Compared to new pulmonary bacteriologically confirmed tuberculosis (NPBCT) patients, there were significantly higher numbers of males (P = 0.04), patients from “Atlantique-Littoral” (P = 0.006), patients aged 45–64 years (P = 0.007), and HIV-positive patients (P = 0.04) among those retreated. Overall, 171 (71%) patients submitted sputum for DST, of whom (163) 95% were positive for Mycobacterium tuberculosis on Xpert MTB/RIF and/or culture and 17 (10%) were rifampicin resistant (9 with MDR-TB and 8 monoresistant to rifampicin). For those without MDR-TB (n = 224), treatment success was 93%. Worse outcomes occurred in those with unknown HIV status (RR: 0.27; 0.05–1.45; P < 0.01) while better outcomes occurred in those who relapsed (RR: 1.06, 95 CI: 1.02–1.10, P = 0.04). Conclusion. In 2013, a high proportion of retreatment patients received DST. Treatment success was good although more needs to be done to systematically increase the final follow-up smear examination. Reasons of high losses to follow-up from “Oueme-Plateau” should be investigated.

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Section: Discussionmentioning

confidence: 99%

Characteristics and Treatment Outcomes of Retreatment Tuberculosis Patients in Benin

Adè

Adjibode

Wachinou

et al. 2016

Tuberculosis Research and Treatment

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“…Thus, efforts to improve transportation and deal with logistical challenges are needed. [22][23][24] Earlier diagnosis of MDR-TB should lead to improved treatment outcomes and reduced TB transmission in the community.…”

Section: Discussionmentioning

confidence: 99%

Management and treatment outcomes of patients enrolled in MDR-TB treatment in Viet Nam

Phương¹,

Nhung²,

Hoa³

et al. 2016

public health action

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“…The response from a participant from Nepal also highlighted the difficulty in attributing a link between evidence and challenge of evidence of policy change: 32 Yes, practice changed to screen all retreatment cases and expand Xpert… I am not sure this was because of the study and the paper published, but there is improvement in the situation, as this was recommended in the paper. The policy has been changed to screen all retreatment TB patients for MDR-TB as much as possible and the Xpert service has been expanded to more places.…”

Section: Challenges In Evidence-policy Linkagementioning

confidence: 99%

Does research through Structured Operational Research and Training (SORT IT) courses impact policy and practice?

Kumar¹,

Shewade²,

Tripathy³

et al. 2016

public health action

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Screening retreatment tuberculosis patients for drug resistance in mid-west Nepal: how well are we doing?

Cited by 6 publications

References 8 publications

Characteristics and Treatment Outcomes of Retreatment Tuberculosis Patients in Benin

Characteristics and Treatment Outcomes of Retreatment Tuberculosis Patients in Benin

Management and treatment outcomes of patients enrolled in MDR-TB treatment in Viet Nam

Does research through Structured Operational Research and Training (SORT IT) courses impact policy and practice?

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