Screening study for potential lead compounds for natural product‐based fungicides: I. Synthesis and in vitro evaluation of coumarins against Botrytis cinerea

Abstract

An efficient, one-pot synthesis of angular and linear dihydropyranocoumarins, along with C-6 and C-8 prenylated coumarins is reported. These compounds, together with single- and furanocoumarins, were tested for their potential antifungal activity against the phytopathogen Botrytis cinerea Pers ex Fr. The results show that furanocoumarins may be able to control the fungus B cinerea.

1-(7-Isopropyl-2,5-dimethyl-8-nitronaphthalen-1-yl)ethanone

“…The reactivity of these sesquiterpenes and their derivatives have been studied extensively by our team in order to prepare new products having biological proprieties (El Haib et al, 2011;Benharref et al, 2013Benharref et al, , 2015Benharref et al, , 2016Zaki et al, 2014). Indeed, these compounds have been tested, using the food poisoning technique, for their potential antifungal activity against the phytopathogen Botrytis cinerea (Daoubi et al, 2004). Herein, we report on the crystal structure of the title compound.…”

1-[(1R,2S,4R,7S)-3,3-Dichloro-4,11,11-trimethyltricyclo[5.4.0.02,4]undecan-7-yl]ethanone

“…The reactivity of this sesquiterpene (and its derivatives) has been studied extensively by our team in order to prepare new products having biological properties (El Jamili et al, 2002;Benharref et al, 2013Benharref et al, , 2015Benharref et al, , 2016Zaki et al, 2014). Indeed, these compounds were tested, using the foodpoisoning technique, for their potential antifungal activity against the phytopathogen Botrytis cinerea (Daoubi et al, 2004). In this paper, we present the crystal structure of the title compound.…”

N-[1,4,4-Trimethyltricyclo[6.3.1.03,9]dodec-8(12)-en-2-yl]acetamide

“…The reactivity of this sesquiterpene and its derivatives has been studied extensively by our team (El Jamili et al, 2002;El Haib et al, 2011;Loubidi et al, 2014;Benharref et al, 2016Benharref et al, , 2017 in order to prepare new products with biological properties. Indeed, these compounds have been tested, using the food-poisoning technique, for their potential antifungal activity against the phytopathogen Botrytis cinerea (Daoubi et al, 2004). Herein, we report the synthesis and crystal structure of the title compound, synthesized by the reaction of 6,7-epoxyhimachalene with BF 3 OEt in acetonitrile under argon.…”