Screening the APC, MLH1, MSH2 and TP53 Mutations in Patients with Early Onset of Colorectal Cancer

Abstract

Objective: A molecular-genetic study of early onset colorectal cancer (CRC) patients in Kazakhstan. Methods:The direct sequencing of crucial regions of key CRC genes (APC codons between nucleotides 967-1386 and 1286-1513; exons 8 and 16 of MLH1 and exon 7 of MSH2; exons 5-9 of TP53) was performed for early cancer-onset and suspected familial cases.