Screening the dermatological potential of <i>Plectranthus</i> species components: antioxidant and inhibitory capacities over elastase, collagenase and tyrosinase

Andrade, Joana M.; Domínguez-Martín, Eva María; Nicolai, Marisa; Faustino, Célia; Rodrigues, Luís Monteiro; Rijo, Patrícia

doi:10.1080/14756366.2020.1862099

Cited by 16 publications

(14 citation statements)

References 60 publications

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“…UA ( Lukhoba et al, 2006 ) and OA ( Dellar et al, 1996 ) are isomeric triterpenic acids that only differ in the position of the methyl (CH 3 ) group on C 29 and always exist simultaneously in the same plant ( Xu et al, 2004 ). In 1971, Misra and colleagues reported the isolation of triterpenes UA ( Lukhoba et al, 2006 ), OA ( Dellar et al, 1996 ) from the methanolic extract of P. bishopianus Benth., which are also found in P. ecklonii ( Misra et al, 1971 ; Andrade et al, 2021 ).…”

Section: Isolated Compounds From Plectranthus Ecklonii Benthmentioning

confidence: 63%

“…In organic extracts of P. ecklonii, high collagenase inhibition has been reported and, further to this, the isolated compounds, OA ( Dellar et al, 1996 ), and UA ( Lukhoba et al, 2006 ), demonstrated higher anti-elastase activity when compared to the extract. This is most probably due to the compounds binding to the catalytic site of the enzyme, justifying its use in dermatology and cosmetics ( Andrade et al, 2021 ). As they share similar structural features, OA ( Dellar et al, 1996 ) and its isomer, UA ( Lukhoba et al, 2006 ), frequently occur simultaneously ( Jesus et al, 2015 ).…”

Section: Isolated Compounds From Plectranthus Ecklonii Benthmentioning

confidence: 99%

“…In a more recent study, the high chelating ability of abietane diterpenes, found in P. ecklonii, was attributed to the observed anti-tyrosinase activity, in vitro , and was considered almost as efficient as kojic acid, the positive control. The combination of polyphenolic compounds, such as quercetin, with abietane diterpenes, has shown a synergistic effect that promotes both anti-tyrosinase and antioxidant activity, suitable for skin treatment, such as, anti-pigmentation ( Andrade et al, 2021 ).…”

Section: Biological Activities Of Isolated Compounds From P Ecklonii Benthmentioning

confidence: 99%

“…The activity of other enzymes, such as collagenase inhibition, in aqueous extracts of P. ecklonii , has recently been established with rosmarinic ( Rice et al, 2011 ) being attributed to promoting the highest amount of biological activity at 4.5%. However, the presence of CA ( Pal et al, 2011 ) in the extracts could also be considered accountable for the increased activity and further studies would be required to positively identify the compounds responsible for the enzyme inhibition ( Andrade et al, 2021 ). RA’s ( Rice et al, 2011 ) inhibitory activity of the enzyme glycosyltransferase (GTF) has been highlighted ( Figueiredo et al, 2010 ) and the presence of this compound has also been linked to the observed effects of AChE inhibition and antioxidant activity ( Falé et al, 2009 ).…”

Section: Biological Activities Of Isolated Compounds From P Ecklonii Benthmentioning

confidence: 99%

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Plectranthus ecklonii Benth: A Comprehensive Review Into its Phytochemistry and Exerted Biological Activities

et al. 2021

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Ethnopharmacological Relevance:Plectranthus genus (Lamiaceae family) contain several species with acknowledged ethnopharmacological uses, such as, for gastrointestinal and respiratory-related problems, due to their anti-inflammatory, antibacterial and antifungal properties. The bioactivity of isolated medicinal compounds from this genus justifies the increased interest in recent times for species of Plectranthus, placing them in the spotlight for natural product drug development.Aim of the study: To the best of our knowledge, this is the first review on the biological activities of Plectranthus ecklonii Benth. As such, the aim of this review was three-fold: 1) to summarize the chemical compounds isolated from P. ecklonii; 2) to collate the biological activities and mechanisms of action of these compounds from in vitro studies; and 3) to evaluate the documented uses and potential applications of this species, in order to postulate on the direction of pharmaceutical uses of this species.Materials and methods: An extensive database retrieval was performed using the electronic databases Web of Science, PubMed, Google Scholar and ScienceDirect. The search criteria consisted of the keywords “Plectranthus ecklonii”, “Plectranthus ecklonii + review”, “Plectranthus ecklonii + diterpenes” or “Plectranthus ecklonii + abietanes”, “ecklonii + parviflorone D”, searched individually and as combinations. Eligibility criteria were set out and titles in English, Portuguese and Spanish were reviewed, with all references included dating from 1970 to 2021. A total of 169 papers were selected and included. Chemical structures were drawn using ChemDraw 20.0, CID numbers were searched in PubChem and the PRISMA diagram was created using PowerPoint 2012.Results: To date, a total of 28 compounds have been isolated from P. ecklonii, including diterpenes, triterpenes, flavonoids, and hydroxycinnamic acids. Most focused on the antimicrobial action of its constituents, although compounds have demonstrated other bioactivities, namely antioxidant, anti-inflammatory and antitumor. The most recent studies emphasize the diterpenoids, particularly parviflorone D, with the help of nanotechnology.Conclusions: The widespread ethnobotanical and traditional uses of P. ecklonii can be scientifically justified by a range of biological activities, demonstrated by isolated secondary metabolites. These bioactivities showcase the potential of this species in the development of economically important active pharmaceutical ingredients, particularly in anticancer therapy.

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Section: Isolated Compounds From Plectranthus Ecklonii Benthmentioning

confidence: 63%

Section: Isolated Compounds From Plectranthus Ecklonii Benthmentioning

confidence: 99%

Section: Biological Activities Of Isolated Compounds From P Ecklonii Benthmentioning

confidence: 99%

Section: Biological Activities Of Isolated Compounds From P Ecklonii Benthmentioning

confidence: 99%

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Plectranthus ecklonii Benth: A Comprehensive Review Into its Phytochemistry and Exerted Biological Activities

et al. 2021

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“…Apart from the extreme effectiveness of IF on elastase inhibition, equalling the effectiveness of EGCG, a natural elastase inhibitor (Andrade et al. 2021 ), IF was the strongest hyaluronidase inhibitor compared to the others ( p < 0.05). Therefore, IF was suggested as a potent natural extract, which exerted anti-wrinkle activities.…”

Section: Resultsmentioning

confidence: 97%

Comparison of chemical profiles, antioxidation, inhibition of skin extracellular matrix degradation, and anti-tyrosinase activity between mycelium and fruiting body of Cordyceps militaris and Isaria tenuipes

Prommaban

Sriyab

Marsup

et al. 2022

Pharmaceutical Biology

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Context Cordyceps militaris and Isaria tenuipes (Cordycipitaceae) are high-value fungi that are used for health-promoting food supplements. Since laboratory cultivation has begun for these fungi, increased output has been achieved. Objective This study compared the chemical profiles, antioxidant, anti-tyrosinase, and skin extracellular matrix degradation inhibition between mycelium and fruiting body of C. militaris and I. tenuipes . Materials and methods The antioxidative potential of 10% v/v aqueous infused extract from each fungus was separately investigated using 2,2-azinobis(3-ethylbenzo-thiazoline-6-sulphonic acid) (ABTS), 1,1-diphenyl-2-picrylhydrazyl (DPPH), ferric reducing antioxidant ability, and ferric thiocyanate methods. The inhibition against MMP-1, elastase, and hyaluronidase were determined to reveal their anti-wrinkle potential. Anti-tyrosinase activities were determined. Results C. militaris and I. tenuipes extracts were found to contain a wide range of bioactive compounds, including phenolics, flavonoids, and adenosine. A correlation was discovered between the chemical compositions and their biological activities. The extract from I. tenuipes fruiting body (IF) was highlighted as an extraordinary elastase inhibitor (IC 50 = 0.006 ± 0.004 mg/mL), hyaluronidase inhibitor (IC 50 : 30.3 ± 3.2 mg/mL), and antioxidant via radical scavenging (ABTS IC 50 : 0.22 ± 0.02 mg/mL; DPPH IC 50 : 0.05 ± 0.02 mg/mL), thereby reducing ability (EC 1 : 95.3 ± 4.8 mM FeSO 4 /g extract) and lipid peroxidation prevention (IC 50 : 0.40 ± 0.11 mg/mL). IF had a three-times higher EC 1 value than ascorbic acid and significantly higher elastase inhibition than epigallocatechin gallate. Discussion and conclusions IF is proposed as a powerful natural extract with antioxidant and anti-wrinkle properties; therefore, it is suggested for further use in pharmaceutical, cosmeceutical, and nutraceutical industries.

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Aromatic plants as cosmeceuticals: benefits and applications for skin health

Olivero-Verbel,

Quintero-Rincón,

Caballero-Gallardo

2024

Planta

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Main conclusion This review highlights the potential of aromatic plants as natural antioxidants in cosmeceuticals to combat skin aging and promote health and rejuvenation. Abstract Aromatic plant extracts, essential oils, or their phytoconstituents have a long history of use in skincare, dating back centuries. Currently, these plant-based sources are extensively researched and utilized in the cosmeceutical industry to formulate products that enhance skin health and promote a youthful appearance. These plants’ diverse bioactivities and sensory properties make them ideal ingredients for developing anti-aging agents recommended for maintaining healthy skin through self-care routines, offering a natural alternative to synthetic products. Reactive oxygen species (ROS) accumulation in the dermis, attributed to intrinsic and extrinsic aging factors, particularly prolonged sun exposure, is identified as the primary cause of skin aging. Plant extracts enriched with antioxidant compounds including flavonoids, phenolics, tannins, stilbenes, terpenes, and steroids, are fundamental to counteract ROS-induced oxidative stress. Noteworthy effects observed from the use of these natural sources include photoprotective, senolytic, anti-inflammatory, anti-wrinkle, anti-acne, and anti-tyrosinase activities, encompassing benefits like photoprotection, wound healing, skin whitening, anti-pigmentation, tissue regeneration, among others. This review highlights several globally distributed aromatic plant species renowned for their benefits for skin, including Foeniculum vulgare Mill. (Apiaceae), Calendula officinalis L. and Matricaria chamomilla L. (Asteraceae), Thymus vulgaris L. (Lamiaceae), Litsea cubeba (Lour.) Pers. (Lauraceae), Althaea officinalis L. (Malvaceae), Malaleuca alternifolia (Maiden y Betche) Cheel (Myrtaceae), Cymbopogon citratus (DC.) Stapf (Poaceae), Rubus idaeus L. (Rosaceae), and Citrus sinensis L. Osbeck (Rutaceae), emphasizing their potential in skincare formulations and their role in promoting health and rejuvenation.

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Screening the dermatological potential of Plectranthus species components: antioxidant and inhibitory capacities over elastase, collagenase and tyrosinase

Cited by 16 publications

References 60 publications

Plectranthus ecklonii Benth: A Comprehensive Review Into its Phytochemistry and Exerted Biological Activities

Plectranthus ecklonii Benth: A Comprehensive Review Into its Phytochemistry and Exerted Biological Activities

Comparison of chemical profiles, antioxidation, inhibition of skin extracellular matrix degradation, and anti-tyrosinase activity between mycelium and fruiting body of Cordyceps militaris and Isaria tenuipes

Aromatic plants as cosmeceuticals: benefits and applications for skin health

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