2024
DOI: 10.1002/pca.3447
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Screening thrombin inhibitors from Yangxinshi tablets by online capillary electrophoresis‐based immobilized enzyme microreactor and molecular docking

Wenping Liu,
Rui Zhou,
Jiake Wen
et al.

Abstract: IntroductionYangxinshi tablet (YXST) is a effective traditional Chinese medicine in treating cardiovascular diseases such as heart failure and myocardial infarction.ObjectivesThis study aims to develop a method for screening thrombin inhibitors from YXST using an online immobilized enzyme microreactor (IMER) based on capillary electrophoresis (CE).Materials and methodsThrombin (THR) was immobilized on the capillary's inner wall using polydopamine (PDA). The chromogenic substrate S‐2238 was employed to assess t… Show more

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