Screening tyrosinase inhibitors from traditional chinese medicine by capillary electrophoresis with electrophoretically mediated microanalysis

Zhang, W.-H.; Lv, Zhi-Hua; Jiang, Tianyue; Wang, Y.-H.; Guo, Lei

doi:10.38212/2224-6614.2055

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Screening Methods Based On the Intrinsic Activity Of The Target Enzyme1

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2021

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“…Zhang et al. 24 also established an EMMA method using longitudinal diffusion as the mixing technique, the inhibitory activities of 21 TCMs on TYR were determined.…”

Section: Screening Methods Based On the Intrinsic Activity Of The Target Enzymementioning

confidence: 99%

Recent advance in the discovery of tyrosinase inhibitors from natural sources via separation methods

Zhang

Bian

Kang

et al. 2021

Journal of Enzyme Inhibition and Medicinal Chemistry

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Tyrosinase (TYR) inhibitors are in great demand in the food, cosmetic and medical industrials due to their important roles. Therefore, the discovery of high-quality TYR inhibitors is always pursued. Natural products as one of the most important sources of bioactive compounds discovery have been increasingly used for TYR inhibitors screening. However, due to their complex compositions, it is still a great challenge to rapid screening and identification of biologically active components from them. In recent years, with the help of separation technologies and the affinity and intrinsic activity of target enzymes, two advanced approaches including affinity screening and inhibition profiling showed great promises for a successful screening of bioactive compounds from natural sources. This review summarises the recent progress of separation-based methods for TYR inhibitors screening, with an emphasis on the principle, application, advantage, and drawback of each method along with perspectives in the future development of these screening techniques and screened hit compounds.

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“…Zhang et al. 24 also established an EMMA method using longitudinal diffusion as the mixing technique, the inhibitory activities of 21 TCMs on TYR were determined.…”

Section: Screening Methods Based On the Intrinsic Activity Of The Target Enzymementioning

confidence: 99%

Recent advance in the discovery of tyrosinase inhibitors from natural sources via separation methods

Zhang

Bian

Kang

et al. 2021

Journal of Enzyme Inhibition and Medicinal Chemistry

View full text Add to dashboard Cite

show abstract

Screening tyrosinase inhibitors from traditional chinese medicine by capillary electrophoresis with electrophoretically mediated microanalysis

Cited by 1 publication

References 0 publications

Recent advance in the discovery of tyrosinase inhibitors from natural sources via separation methods

Recent advance in the discovery of tyrosinase inhibitors from natural sources via separation methods

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