Screening Women With Polycystic Ovary Syndrome for Metabolic Syndrome

Dokras, Anuja; Bochner, M.P.; Hollinrake, E.M.; Markham, Sanford M.; Voorhis, Bradley J. Van; Jagasia, Dinesh

doi:10.1097/01.aog.0000167408.30893.6b

Cited by 291 publications

(211 citation statements)

References 25 publications

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“…HDL cholesterol less than 50 mg/dl had 84% positive predictive value for the metabolic syndrome which is supported by the study of Dokras et al 11 showing triglycerides/HDL-C ratio > 3, having high 10 who had shown a significant (P < 0.001) increasing trend in the proportion of women with the metabolic syndrome as related to the fasting insulin concentration. This trend remained significant (P = 0.001) even after adjusting for BMI.…”

Section: Discussionmentioning

confidence: 52%

Association of metabolic syndrome in polycystic ovarian syndrome: an observational study

Dey

Mukherjee

Roybiswas

et al. 2011

J Obstet Gynecol India

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Section: Discussionmentioning

confidence: 52%

Association of metabolic syndrome in polycystic ovarian syndrome: an observational study

Dey

Mukherjee

Roybiswas

et al. 2011

J Obstet Gynecol India

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“…Lipid profile was estimated by using enzymatic colorimetric technique, and the criteria adopted were in consonance with NCEP-ATP III guidelines [10]. Blood sugar values were determined during a 75-g oral glucose tolerance test (OGTT) [11] and were assessed according to WHO, 2002. The presence of insulin resistance was defined if fasting insulin was [25 mg/dL or if insulin level post 75 g glucose load was [55 mg/dL, respectively [12,13].…”

Section: Sample Collection and Estimationmentioning

confidence: 99%

Endocrine and Metabolic Profile of Different Phenotypes of Polycystic Ovarian Syndrome

Saxena

Shivani

Bhattacharjee

2016

J Obstet Gynecol India

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Background Polycystic ovarian syndrome (PCOS) is a common endocrinopathy associated with wide heterogeneity and serious clinical implications. Prevalence and characteristics of different phenotypes are not well defined. Therefore, this study was planned to determine the prevalence of four phenotypes of PCOS and to evaluate their endocrine and metabolic parameters including insulin resistance and metabolic syndrome with respect to controls. Methods This observational, case-control study was conducted in the gynecology outpatient department of a tertiary care center where 161 PCOS and 50 non-PCOS women were recruited and investigated.Results All phenotypes of PCOS had higher BMI with respect to controls (P \ 0.000). Overweight women were maximum in phenotype H ? O followed by phenotype H ? P. Significantly higher levels of luteinizing hormone (P \ 0.01), testosterone (P \ 0.0001), were observed in all phenotypes of PCOS as compared to controls. Serum cholesterol (P \ 0.026) and triglycerides (P \ 0.05) were significantly higher in all PCOS phenotypes compared to controls. Levels of fasting (P \ 0.000) and post-prandial

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“…The data regarding the prevalence of metabolic syndrome in PCOS are scarce, and limited only to the USA (13)(14)(15)(16)(17) and Europe (18)(19)(20). In the USA population, its prevalence in adolescents was 37% (14), while in adult women it varied from 34.4% (16) to 47.9% (17).…”

mentioning

confidence: 99%

Metabolic syndrome in women with polycystic ovary syndrome: prevalence, characteristics and predictors

Marcondes

Hayashida

Barcellos

et al. 2007

Arq Bras Endocrinol Metab

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The aim of this study was to determine the prevalence of metabolic syndrome in women with polycystic ovary syndrome, as well as its characteristics and predictors. Seventh-three women, with body mass index of 30.4 ± 7.8 kg/m 2 and 25.0 ± 6.0 years old, subdivided according to body mass index, were studied retrospectively. There was no significant mean age difference among body mass index groups (p = 0.228). Prevalence of metabolic syndrome was 38.4%, with a null prevalence for normal (n = 18), 23.8% for overweight (n = 17), 62.9% for obese (n = 28), and 85.5% for morbidly obese women (n = 7). Women with metabolic syndrome were older than women without metabolic syndrome (27.3 ± 5.3 vs. 24.2 ± 4.6 vs. years old; p = 0.031) and presented a higher body mass index (36.3 ± 7.7 vs. 26.9 ± 5.4; p < 0.001). There was no difference for degree of hirsutism and menstrual patterns between women with and without metabolic syndrome (p = 0.593 and p = 0.119, respectively). Regarding laboratory parameters, DHEAS was lower (1,646 ± 1,007 vs. 2,594 ± 1,563; p = 0.007) and HOMA-IR were higher (9.9 ± 9.7 vs. 4.6 ± 4.7; p = 0.004) in women with metabolic syndrome (p = 0.031 and p < 0.001, respectively). The best predictors of metabolic syndrome were waist circumference > 88 cm, HDL-cholesterol < 50 mg/dL and triglycerides ≥ 150 mg/dL. O objetivo deste estudo foi o de determinar a prevalência, características e preditores da síndrome metabólica em mulheres com a síndrome dos ovários policísticos. Setenta e três mulheres, com índice de massa corporal de 30,4 ± 7,8 kg/m 2 e 25,0 ± 6,0 anos de idade, subdivididas de acordo com o índice de massa corporal, foram estudadas retrospectivamente. Não se observou diferença significativa de idade entre os grupos (p = 0,228). A prevalência da síndrome metabólica foi de 38,4%, estando ausente nas mulheres com índice de massa corporal normal (n = 18) e presente em 23,8% das com sobrepeso (n = 17), 62,9% das obesas (n = 28) e 85,5% das obesas mórbidas (n = 7). Quando comparadas, as mulheres com síndrome metabólica apresentaram uma idade mais avançada (27,3 ± 5,3 vs. 24,2 ± 4,6 anos; p = 0,031) e um índice de massa corporal maior (36,3 ± 7,7 vs. 26,9 ± 5,4; p < 0,001) que as mulheres sem a síndrome, não havendo diferença significativa com relação ao grau de hirsutismo (p = 0,593) e padrão menstrual (p = 0,119). Com relação aos parâmetros laboratoriais, a concentração de DHEAS foi menor (1.646 ± 1.007 vs. 2.594 ± 1.563; p = 0,007) e o valor do HOMA-IR foi maior (9,9 ± 9,7 vs. 4,6 ± 4,7; p = 0,004) nas pacientes com a síndrome metabólica. Os melhores preditores para a presença da síndrome metabólica foram a circunferência abdominal > 88 cm, HDL-colesterol < 50 mg/dL e triglicérides ≥ 150 mg/dL.

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Screening Women With Polycystic Ovary Syndrome for Metabolic Syndrome

Abstract: II-2.

Cited by 291 publications

References 25 publications

Association of metabolic syndrome in polycystic ovarian syndrome: an observational study

Association of metabolic syndrome in polycystic ovarian syndrome: an observational study

Endocrine and Metabolic Profile of Different Phenotypes of Polycystic Ovarian Syndrome

Metabolic syndrome in women with polycystic ovary syndrome: prevalence, characteristics and predictors

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