2009
DOI: 10.1142/s1793048009000995
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Screw Motion of Dna Duplex During Translocation Through Pore I: Introduction of the Coarse-Grained Model

Abstract: Based upon the structural properties of DNA duplexes and their counterion-water surrounding in solution, we have introduced here a screw model which may describe translocation of DNA duplexes through artificial nanopores of the proper diameter (where the DNA counterion-hydration shell can be intact) in a qualitatively correct way. This model represents DNA as a kind of "screw," whereas the counterion-hydration shell is a kind of "nut." Mathematical conditions for stable dynamics of the DNA screw model are inve… Show more

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Cited by 7 publications
(7 citation statements)
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“…The passage of polymers thorough the nanopores is also important in many chemical and industrial processes. In this context, nanotechnological applications try to emulate the complex biological processes involved in the translocation problem [4][5][6].…”
Section: Introductionmentioning
confidence: 99%
“…The passage of polymers thorough the nanopores is also important in many chemical and industrial processes. In this context, nanotechnological applications try to emulate the complex biological processes involved in the translocation problem [4][5][6].…”
Section: Introductionmentioning
confidence: 99%
“…[1] The passage of polymers thorough nanopores is also a fundamental problem in chemical and industrial processes. In this context, many efforts are made in nanotechnological applications, that try to emulate the complex biological processes involved in the translocation problem [2][3][4]. An important related application is the use of nanopores to unzip and translocate single DNA chains with the purpose of perform fast and detailed DNA sequencing [5][6][7][8][9].…”
Section: Introductionmentioning
confidence: 99%
“…Recently a model has been presented in order to describe the main features of the φ29 bacteriophage translocation dynamics [12], as a biological extension of a time varying driven translocation of long molecules [13,14]. The idea of the model is to drive a polymer chain in one direction with a constant force, while in its activated state, but leave the polymer to diffuse freely when the motor is inactive [12,15,16]. The mechanism is the origin of the Michaelis-Menten (MM) polymer velocity, related to a microscopic reinterpretation of the MM enzymatic reaction [12].…”
Section: Introductionmentioning
confidence: 99%