Scrotal Abscess as Initial Presentation of Squamous Cell Carcinoma

Huen, Kathy H.; Nourparvar, Paymon; DeCaro, John J.; Walsh, Mark D.; Issa, Muta M.; Ritenour, Chad W.M.

doi:10.1155/2013/807346

Cited by 7 publications

(7 citation statements)

References 8 publications

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“…Over 83% (5/6) of patients who did undergo DRE demonstrated positive findings, including a palpable mass (4), purulent anal drainage (1), and pain out of proportion (1). This over 80% rate of positive findings on DRE is consistent with a study by the World Journal of Gastroenterology in 2015 which showed that preoperative DRE resulted in positive findings in 75% of FG with underlying rectal cancer and it highlights the importance of including a thorough anorectal examination in all patients with FG [ 1 , 3 , 15 - 17 ].…”

Section: Discussionsupporting

confidence: 89%

“…Local procedures and chronic indwelling catheters increase the risk of infection. Chemotherapy as a treatment for a previously diagnosed unrelated cancer was seen in 15% (3/20) of the case reports [3][4][5][6][7].…”

Section: Epidemiology and Risk Factorsmentioning

confidence: 99%

“…Ultrasonography may be helpful as a rapid initial (bedside) imaging modality and can be useful when CT is not immediately available. Sonographic findings of FG may include identification of fluid collections or mass-like lesion, tissue edema, or air shadows indicative of tissue emphysema [3,5].…”

Section: Diagnosismentioning

confidence: 99%

“…In our review, rectal adenocarcinomas were responsible for 70% (14/20) of cases. The remaining cases included two colonic adenocarcinomas and isolated cases of prostatic adenocarcinoma, scrotal pleomorphic sarcoma, urethral squamous cell carcinoma, and scrotal squamous cell carcinoma [3,5,9,10]. In two patients with malignancy-induced FG, the tissue was not sent for histopathologic analysis.…”

Section: Tissue Biopsymentioning

confidence: 99%

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Fournier’s Gangrene in the Setting of Underlying Carcinoma: A Case Report and Review of the Literature

Mann

Reinoso

Genuit

et al. 2020

Cureus

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Most case series of Fournier's gangrene (FG) do not list malignancy as a cause; however, isolated cases with underlying malignancy of the soft tissue, genitourinary, and gastrointestinal systems have been described. After a review of recently published literature, 20 case reports and 15 case series or review articles included relevant information and were included in this literature review. Malignancy is overlooked in 10% (2/20) of patients, resulting in a delayed diagnosis and initiation of cancer treatment. All patients with FG should have a thorough cancer history, digital rectal examination, appropriate local and systemic imaging, as well as tissue biopsies, to reduce the likelihood of a missed cancer diagnosis. Delay in management of the local malignancy may lead to persistence or recurrence of the infection and significantly worsens overall outcome and survival.

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Section: Discussionsupporting

confidence: 89%

Section: Epidemiology and Risk Factorsmentioning

confidence: 99%

Section: Diagnosismentioning

confidence: 99%

Section: Tissue Biopsymentioning

confidence: 99%

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Fournier’s Gangrene in the Setting of Underlying Carcinoma: A Case Report and Review of the Literature

Mann

Reinoso

Genuit

et al. 2020

Cureus

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“…Patient 2 presented with T4 N1 M1 disease and locally destructive mass as well as confirmed metastatic intraabdominal lymph node involvement. Both patients had delayed presentations to a health care professional, which is in keeping with the literature [8].…”

Section: Discussionsupporting

confidence: 85%

Squamous cell carcinoma of the scrotum in HIV: two case reports

2021

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Background Squamous cell carcinoma (SCC) of the scrotum was the first malignancy known to be associated with exposure to an occupational carcinogen—in this case, soot trapped in the breeches of chimney sweeps. Better civil rules and regulations and the replacement of hearths with other forms of heating have rendered SCC of the scrotum a rarity. We report two cases of scrotal SCC with vastly differing clinical presentations and management. Case presentation Case 1 had T1 N0 M0 disease and presented with a small (< 2 cm), innocuous-looking, non-healing ulcer of eight years duration. A punch biopsy revealed a superficially invasive SCC confirmed on immunohistochemical profiling. A wide local excision of the lesion was subsequently performed. Follow-up at three years showed no signs of recurrence. Case 2 presented with T4 N1 M1 disease and rapidly progressing locally destructive mass. A punch biopsy of the scrotal lesion confirmed invasive moderately differentiated focally keratinising SCC. The metastatic evaluation confirmed the presence of metastatic, extensive para-aortic lymphadenopathy. He was managed with cisplatin-based chemoradiotherapy. Conclusion Early detection and management of patients with SCC of the scrotum are essential. If the diagnosis is delayed, treatment options become limited, and the prognosis is poor. Notwithstanding the rarity of this disease, multicentre trials are needed to provide more precise guidelines as to the optimal management of these patients.

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