Scrotal Pyoderma Gangrenosum Associated with Evans Syndrome

Yang, Deng‐Ho; Yang, Meng‐Yin

doi:10.3390/jcm7090230

JCM

2018

DOI: 10.3390/jcm7090230

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Scrotal Pyoderma Gangrenosum Associated with Evans Syndrome

Deng‐Ho Yang

Meng‐Yin Yang

Abstract: Evans syndrome is a rare disorder with presentations of autoimmune hemolytic anemia and immune thrombocytopenia, in the absence of any underlying cause. Here, we reported a case with a history of Evans syndrome for seven years. A persistent scrotal ulcer with severe pain occurred for two weeks. He called at our emergency room because of a painful, necrolytic cutaneous ulcer over the scrotal region. A biopsy showed sterile dermal neutrophilia with lymphocytic vasculitis, and pyoderma gangrenosum was impressed. … Show more

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2024

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“…Iron deficiency anemia is associated with the highest incidence [1]. Our review of previous literature revealed three cases of hemolytic anemia (such as Evans syndrome) [2] and three cases of Fanconi anemia (congenital aplastic anemia) [3] associated with PG, but no cases of acquired aplastic anemia were observed. In previous reports, the onset of hematological disorders preceded that of PG in most cases [3].…”

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Pyoderma gangrenosum of the mons pubis associated with aplastic anemia

Yoshizaki,

Fujii,

Baba

et al. 2024

J. Cutan. Immunol. Allergy

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Dear Editors, Pyoderma gangrenosum (PG) is often associated with hematological disorders such as leukemia, monoclonal gammopathy, and myelodysplastic syndrome. However, association of PG with aplastic anemia is rare. We experienced a patient with PGassociated aplastic anemia.A 90-year-old Japanese woman had a painful subcutaneous induration on her mons pubis for 2 months and underwent a biopsy elsewhere. Only nonspecific inflammatory infiltrates in the adipose tissue were revealed. The biopsy site gradually ulcerated and multiple ulcers were observed. She was referred to our department for evaluation of the skin ulcers 10 days after the biopsy (Figure 1A). At her first visit, she was receiving prednisolone (PSL) (5 mg/day) and cyclosporine (CyA) (150 mg/day) for aplastic anemia, which was diagnosed 6 years earlier. As Escherichia coli (E. Coli) was detected in the wound, we initiated the administration of oral minocycline and topical anti-ulcer ointment. Moreover, we also reduced the dose of PSL to 3 mg/day and discontinued CyA considering the possibility of secondary wound infection in the immunosuppressed patient. However, the ulcer persisted and further enlarged centrifugally and fused to form a large ulcer in 3 months (Figure 1B). We performed a biopsy again of the ulcer edge, which revealed a deep ulcer and dense infiltration of neutrophils, lymphocytes, and histiocytes throughout the dermis (Figures 1C, D). Her red blood cell, white blood cell, and platelet counts were 235 × 10 4 /μL, 6.9 × 10 3 /μL, and 242 × 10 3 /μL, respectively, and her CRP was 2.5 mg/dL. Based on the clinical and histological findings, a diagnosis of PG was made. Additionally, the dose of PSL was increased to 20 mg/day and CyA was restarted with only a limited effect. Adalimumab was administered, and the ulcer began to shrink. However, the drug was discontinued after one administration because of cytomegalovirus infection. She started to receive oral ganciclovir and PSL and CyA were discontinued due to the cytomegalovirus infection. She was transferred to another hospital and the wound continues to grow because PSL and CyA were not given. Since the cytomegalovirus infection is still present, adalimumab was not been restarted.PG is a rare inflammatory skin disorder characterized clinically by painful ulcers with necrotic surfaces and histologically by dense infiltration of neutrophils. The condition is often associated with systemic comorbidities, including inflammatory bowel disease,

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confidence: 80%

Pyoderma gangrenosum of the mons pubis associated with aplastic anemia

Yoshizaki,

Fujii,

Baba

et al. 2024

J. Cutan. Immunol. Allergy

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Scrotal Pyoderma Gangrenosum Associated with Evans Syndrome

Cited by 1 publication

References 18 publications

Pyoderma gangrenosum of the mons pubis associated with aplastic anemia

Pyoderma gangrenosum of the mons pubis associated with aplastic anemia

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