Scrub typhus – A case series from the state of Sikkim, India

Mohanty, Aroop; Kabi, Ankita; Gupta, Pratima; Jha, Mithilesh Kumar; Rekha, U Sasi; Raj, Anusha Krishna

doi:10.4103/ijciis.ijciis_50_19

Cited by 8 publications

(4 citation statements)

References 22 publications

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“…It also occurs in Nepal, Pakistan, and Papua New Guinea stationed in the rural or jungle areas in Pacific Theatre. 3 During World War II scrub typhus killed thousands of troops who were stationed in the rural or jungle areas in the Pacific Theatre. 4 In 1916 Weil and Felix described heterophilic antibody aggregation of OX-2 and OX-19 strains of Proteus mirabilis by typhus sera.…”

Section: Introductionmentioning

confidence: 99%

“…Symptoms like headache, fever, rash, myalgia, cough and lymphadenopathy occur after 6-12 days of incubation. 3 Clinical diagnosis of scrub typhus is often made by the presence of an eschar and the treatment is often started mainly on clinical grounds. Tetracycline 500 mg, QID or doxycycline 200 mg, OD for seven days is the treatment of choice.…”

Section: Introductionmentioning

confidence: 99%

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Prominent early adulthood hyperferritinemia in scrub typhus

Naskar,

Chaudhuri,

Basak

et al. 2024

Int J Adv Med

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Background: Scrub typhus is an acute infectious disease, caused by Orientia tsutsugamushi. It is endemic to a geographically distinct region of Japan, Taiwan, China, and South Korea, known as the tsutsugamushi triangle, as well as in Nepal, Pakistan, and Papua New Guinea. In India, the incidence of this disease varies from 4-46% with high morbidity and mortality. Methods: In this cross-sectional study at a tertiary care hospital in Kolkata, India we analysed ferritin blood levels along with different demographic and laboratory test parameters of 60 suspected scrub typhus patients who were also scrub typhus IgM antibody positive during a one-year study period. Results: It was found that serum ferritin levels were unusually high in 21-40 years age group patients along with mildly increased urea and creatinine levels. Other important findings were below 40 years of age males were mostly affected, but above 40 years of age, females were generally affected. Haemoglobin and platelet levels were normal in all age groups. Although WBC count and neutrophils were normal in the 21-40 years age group, in other age groups increased levels were observed. CRP, SGPT, and SGOT levels were uniformly high above 20 years of age. Electrolytes were mildly decreased. Conclusions: It appears that oxidative stress-induced acute kidney injury may be an important reason for the rising ferritin levels in the 21-40 years age group. These important findings may be helpful to clinicians in management of these patients.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Prominent early adulthood hyperferritinemia in scrub typhus

Naskar,

Chaudhuri,

Basak

et al. 2024

Int J Adv Med

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“…Scrub typhus is an acute febrile and zoonotic disease caused by orientia tsutsugamushi, an obligate, intracellular, Gram-negative bacteria isolated in 1930 [1]. The population is universally susceptible to orientia tsutsugamushi [2], and the incubation period for this disease ranges from 1 to 3 weeks.…”

Section: Introductionmentioning

confidence: 99%

Scrub typhus manifesting with Temporal lobe hemorrhage: a Case report

Chen,

Zheng

2023

Preprint

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Background: Tsutsugamushi disease, alternatively known as Scrub Typhus, is a natural focus disease caused by Rickettsia tsutsugamushi. Clinical manifestations include sudden onset, fever, eschar or ulceration at the bite site, lymphadenopathy, and rash. Moreover, severe scrub typhus can present with a variety of symptoms. Timely diagnosis and appropriate intervention are critically linked to the prognosis of scrub typhus. Case presentation: The patient, a 57-year-old woman, was admitted to our hospital with primary symptoms of fever and headache. Brain computed tomography (CT) scan revealed a hemorrhage in the temporal lobe, leading to her admission to our hospital's Department of Neurosurgery. Subsequently, the patient was transferred to the Intensive Care Unit (ICU) due to severe respiratory failure and hypotension. Ultimately, the clinical diagnosis of severe scrub typhus was established. Conclusion: Early diagnosis and timely intervention of scrub typhus are crucial for improving the disease's prognosis. Clinicians must heighten their awareness of scrub typhus to facilitate early detection and prompt treatment. The review of the disease progression in this case indicates that, in patients with scrub typhus, despite the absence of severe coagulopathy and DIC, the potential risk of cerebral hemorrhage should still be vigilantly monitored. Moreover, consideration should be given to the potential risk of scrub typhus infection in patients with cerebral hemorrhage and unexplained fever, especially in areas where scrub typhus is endemic.

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“…Scrub typhus is a life-threatening zoonotic disease caused by Orientia tsutsugamushi, an obligate, intracellular, Gram-negative bacteria isolated in 1930 [ 1 ]. The disease derives its name from the scrub vegetation where its vector, Leptotrombidium mite, resides.…”

Section: Introductionmentioning

confidence: 99%

Scrub Typhus Co-Infections in a Young Boy With Varicella and Malaria: A Rare Case Report

Pandey¹,

Mohanty²,

Matlani³

et al. 2022

Cureus

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Scrub typhus is one of the leading causes of acute febrile illness of unknown origin in India. Though several co-infections of other vector-borne diseases have been described in the literature, few such cases have been described in children. As such, it is challenging to diagnose scrub typhus alone and becomes that more complicated when a varicella infection precedes it. This is the first reported case where scrub with varicella infection also had concomitant malaria. In such cases, prompt diagnosis and initiation of the correct drug are imperative. Here we describe a six-year-old child with a past history of varicella infection and co-infected with scrub typhus and malaria.

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Scrub typhus – A case series from the state of Sikkim, India

Cited by 8 publications

References 22 publications

Prominent early adulthood hyperferritinemia in scrub typhus

Prominent early adulthood hyperferritinemia in scrub typhus

Scrub typhus manifesting with Temporal lobe hemorrhage: a Case report

Scrub Typhus Co-Infections in a Young Boy With Varicella and Malaria: A Rare Case Report

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