Scrutinizing pathways of nicotine effect on renal Alpha-7 nicotinic acetylcholine receptor and Mitogen-activated protein kinase (MAPK) expression in Ehrlich ascites carcinoma-bearing mice: Role of Chlorella vulgaris

Exploring the Role of Phenolic Compounds in Chronic Kidney Disease: A Systematic Review

“…Further research has shown that polyphenol-rich foods, including Indian plums [ 124 ], radishes [ 125 , 126 ], green algae [ 127 ], acacia gum [ 128 ], basil leaves [ 129 , 130 ], essential oils [ 131 ], coffee and olive oils [ 132 ], and red palm oil [ 133 , 134 ], can ameliorate kidney damage induced by various toxins. Moreover, phenolic compounds have shown promising results in preventing further heavy-metal-induced kidney injury [ 135 , 136 , 137 ].…”

“…Myricetin [118] ↓ BUN, β2-MG, and Cys C ↑ GR activity, TAS and GPx, MDA ↓ TNF-α and IL-1β [118] Tannins, phenolics, flavonoids, steroid glycosides, terpenoids, and saponins [119] ↓ serum concentrations of BUN and creatinine ↓ renal tubular and glomerular alterations [119] Gallic acid, (+)-catechin, (-)-epicatechin, and ellagic acid [120] ↓ ALT and AST activities ↓ MDA, APOP and NO in plasma, heart, and kidney ↓ uric acid level, and plasma creatinine level [120] Chlorogenic acid, diosmin, and caffeic acid [122] ↓ urinary NGAL, endothelin-1, and clusterin levels ↓ BUN, creatinine, 8-OHda, isoprostane, adiponectin, and cystatin ↓ serum XOD, liver XOD, serum ADA, liver ADA, and serum UA levels [121] 6-Shogaol, 6-Paradol, and 6-Gingerol [123] ↓ plasma and blood creatinine and urea ↓ GSH level ↑ SOD level [123] Ferulic acid, caffeic acid and vanillic acid [124] ↓ MDA, APOP, uric acid and creatinine levels in the blood, IL-1, IL-6, TNF-α, TGF-β1, and NF-κB ↑ catalase and SOD activities in the kidneys [124] Chlorogenic, vanillic, caffeic, syringic, p-coumaric, and ferulic acids [126] ↓ serum urea, uric acid and creatinine levels ↑ kidney SOD, CAT, GPx, GST, and GR activities [125] Lutein and chlorophyll [127] ↑ CAT and SOD ↓ urea, creatinine, uric acid, GGT, CK, BUN, and β2-microglobulin ↓ levels of TNFα, IL-6, IL-β, and TGF-α [127] Benzoic acids [128] ↓ levels of Nrf2 and SOD1 in renal tissue Normal architecture of renal tissue (renal corpuscle, proximal and distal convoluted tubules, and collecting ducts) [128] Rosmarinic acid [130] ↓ serum creatinine, BUN, and uric acid [129] Eugenol [131] ↓ oxidative stress, inflammation, and apoptosis ↓ proinflammatory markers (IL6 and TNF-α) [131] Chlorogenic acid, hydroxytyrosol, and tyrosol [132] ↓ creatinine, uric acids, and BUN [132] Pyrogallol, 4-hydroxybenzoic acid, gallic acid, and ferulic acid [134] ↑ GSH, SOD, CAT ↓ MDA [133] Secoisolariciresinol diglucoside [135] ↓ levels of NO and MPO ↑ superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase…”

Acrylamide-targeting renal miR−21a−5p/Fibrotic and miR122-5p/ inflammatory signaling pathways and the role of a green approach for nano-zinc detected via in silico and in vivo approaches

“…The kidneys play a pivotal role in maintaining physiological homeostasis, including filtration, excretion, and regulation of essential substances ( Abdel-Rahman Mohamed et al, 2022b ). Any disruption in renal function can have cascading effects on overall health ( Abdel-Rahman Mohamed et al, 2022a ). Understanding how acrylamide affects kidney tissue is vital for comprehending its broader implications on systemic health.…”

The Influence of Diet and Its Components on the Development and Prevention of Hepatocellular Carcinoma (HCC)

“…Chlorella has become a popular superfood in recent years. It is consumed as an additive in shakes in powder form and used as a dietary supplement [ 96 ]. Chlorella is a single-celled algae whose main property is detoxifying tissues from heavy metals and providing nutrients and vitamins [ 96 ].…”

“…It is consumed as an additive in shakes in powder form and used as a dietary supplement [ 96 ]. Chlorella is a single-celled algae whose main property is detoxifying tissues from heavy metals and providing nutrients and vitamins [ 96 ]. The impact of ethanol and polysaccharide extracts from algae was evaluated by Nunghathai Sawasdee et al in terms of HCC cell survival, with the results indicating anti-cancer effects [ 97 ].…”