Scurvy as a mimicker of osteomyelitis in a child with autism spectrum disorder

Kinlin, Laura M.; Blanchard, Ana C.; Silver, Shawna; Morris, Shaun K.

doi:10.1016/j.ijid.2018.02.002

Cited by 24 publications

(23 citation statements)

References 10 publications

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“…According to case reports of scurvy, in addition to fatigue, anemia, bruising, hematomas, and different types of pain, vitamin C deficiency has been associated with various cardiovascular symptoms [67,68,69,70,71,72,73,74,75,76], dyspnea [64,70,71,72,73,74,75,76,77,78,79,80,81], lower limb edema [13,64,66,70,72,80,160,161,162,163,164,165,166,167,168,169,170,171,172,173,174,175], infection-type symptoms [66,67,68,73,160,161,165,167,174,175,176,177], bleeding in the gastrointestinal and other regions [76,164,172,175,177,178,…”

Section: Discussionmentioning

confidence: 99%

Vitamin C Can Shorten the Length of Stay in the ICU: A Meta-Analysis

2019

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A number of controlled trials have previously found that in some contexts, vitamin C can have beneficial effects on blood pressure, infections, bronchoconstriction, atrial fibrillation, and acute kidney injury. However, the practical significance of these effects is not clear. The purpose of this meta-analysis was to evaluate whether vitamin C has an effect on the practical outcomes: length of stay in the intensive care unit (ICU) and duration of mechanical ventilation. We identified 18 relevant controlled trials with a total of 2004 patients, 13 of which investigated patients undergoing elective cardiac surgery. We carried out the meta-analysis using the inverse variance, fixed effect options, using the ratio of means scale. In 12 trials with 1766 patients, vitamin C reduced the length of ICU stay on average by 7.8% (95% CI: 4.2% to 11.2%; p = 0.00003). In six trials, orally administered vitamin C in doses of 1–3 g/day (weighted mean 2.0 g/day) reduced the length of ICU stay by 8.6% (p = 0.003). In three trials in which patients needed mechanical ventilation for over 24 hours, vitamin C shortened the duration of mechanical ventilation by 18.2% (95% CI 7.7% to 27%; p = 0.001). Given the insignificant cost of vitamin C, even an 8% reduction in ICU stay is worth exploring. The effects of vitamin C on ICU patients should be investigated in more detail.

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Section: Discussionmentioning

confidence: 99%

Vitamin C Can Shorten the Length of Stay in the ICU: A Meta-Analysis

2019

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“…These include lethargy, irritability, arthralgia, and myalgia 6,7,20,67 . Follicular hyperkeratosis and ecchymosis/hemorrhage can occur as soon as 3 months after deficient vitamin C intake 7,9,67 …”

Section: Discussionmentioning

confidence: 99%

“…Literature reviewed yielded 77 cases of scurvy described in 65 published papers (Table S1), in addition to the two cases described here 1,8,9,11‐73 …”

Section: Literature Reviewmentioning

confidence: 99%

“…It is not stored in any reservoir within the body and is widely distributed in intracellular and extracellular tissues 6 . Humans require a dietary source of vitamin C to maintain health, as this micronutrient is not endogenously produced 9 . Plasma concentration of vitamin C is related to its dietary intake and its half‐life is 10‐20 days 6 .…”

Section: Introductionmentioning

confidence: 99%

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The risk for scurvy in children with neurodevelopmental disorders

Kothari¹,

Tate

Adewumi

et al. 2020

Special Care in Dentistry

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Background: Scurvy, the disease resulting from vitamin C deficiency, is perceived as being rare and occurring predominantly in the past. However, scurvy continues to exist and may be encountered in children with medical/developmental conditions and/or restricted diet. Diagnosis can be challenging given the perceived rarity of the condition and nonspecific symptoms, including gingival disease. Methods:We present a series of two cases of scurvy in which the affected children presented to medical attention with dental complaints. Additional cases of scurvy are described, based on the literature review of case reports/series published in the last 10 years.

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“…As food selectivity is the most common type of feeding difficulty in children with ASD, they are at risk of nutritional deficiencies, with resulting diverse health impacts. Studies have demonstrated that children with ASD had a greater number of nutritional deficiencies compared to typically developing children . Vitamin A, vitamin D and calcium deficiencies have been shown to be significantly more common in children with ASD with feeding difficulties .…”

Section: Health and Psychosocial Impacts Of Feeding Difficulties In Cmentioning

confidence: 99%

Feeding difficulties in children with autism spectrum disorder: Aetiology, health impacts and psychotherapeutic interventions

Zhu

Dalby‐Payne

2019

J Paediatrics Child Health

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Feeding difficulties are common and significant issues for children with autism spectrum disorder and their families. Key features of autism are intrinsically linked with factors contributing to these children's feeding difficulties. Following a multidisciplinary assessment to exclude non-behavioural reasons for the feeding difficulty, there are two mainstay modalities of treatment: operant conditioning and systematic desensitisation. Currently, evidence points towards operant conditioning as the most efficacious psychotherapy. However, recent research into cognitive behavioural therapy for older children with feeding difficulties has shown promising results and will be an area to monitor in the coming years. This review outlines the causes and health impacts and evaluates current evidence supporting the available psychotherapeutic interventions for children with autism spectrum disorder experiencing feeding difficulties. References 1 Baio J, Wiggins L, Christensen DL et al. Prevalence of autism spectrum disorder among children aged 8 years-Autism and developmental disabilities monitoring network, 11 sites, United States, 2014.

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Scurvy as a mimicker of osteomyelitis in a child with autism spectrum disorder

Cited by 24 publications

References 10 publications

Vitamin C Can Shorten the Length of Stay in the ICU: A Meta-Analysis

Vitamin C Can Shorten the Length of Stay in the ICU: A Meta-Analysis

The risk for scurvy in children with neurodevelopmental disorders

Feeding difficulties in children with autism spectrum disorder: Aetiology, health impacts and psychotherapeutic interventions

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