Scutellarein induces apoptosis and inhibits proliferation, migration, and invasion in ovarian cancer via inhibition of EZH2/FOXO1 signaling

Xiao, Lei; Zheng, Chen; Qi, Yan; Xu, Manfei; Liu, Wei; He, Qiaojun; Zhang, Yue; Cheng, Weiwei; Zhao, Wenxia

doi:10.1002/jbt.22870

Cited by 18 publications

(15 citation statements)

References 39 publications

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“…Another study showed that it reduces tubular epithelial cell death and inflammation in ischemic kidney injury by degrading the COX-2 protein 61 . In colon and ovarian cancers, it inhibits metastasis and proliferation and induces apoptosis 62,63 . Beta-sitosterol and quercetin were found to enhance brain development and quercetin alleviates oxidative damage 64,65 .…”

Section: Discussionmentioning

confidence: 99%

Integrating network pharmacology and pharmacological evaluation to investigate the anticancer effects of Duranta erecta Linn. Verbenaceae in breast cancer

Agbana¹,

Abu²,

Akinleye³

et al. 2023

Preprint

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Objective Breast cancer is the most prevalent type of cancer among women in sub-Saharan Africa. Efforts are being made to tackle the disease. However, numerous challenges are still reported. Duranta erecta showed medicinal relevance in different ailments but its molecular mechanism of action in breast cancer is not unraveled. The objective of this study is to evaluate the anticancer effect of Duranta erecta on breast cancer cells and determine the molecular mechanism of action in silico. Materials and Methods The Phytochemical Interaction Database, published literature, and the Swiss TargetPrediction database, respectively, were used to identify the active ingredients and targets of Duranta erecta. GEO datasets and TCGA databases were searched for breast cancer-related targets. A protein-protein interaction (PPI) network was constructed to screen the primary targets. For GO and KEGG pathway enrichment analyses, ShinyGO was used. By using molecular docking, interactions between potential targets and active substances were evaluated. MTT assay was conducted to evaluate the cytotoxicity effect of Duranta erecta. Results Duranta erecta demonstrated a cytotoxic effect on breast cancer cells. The IC50 values are 9.99 µg/mL and 15.07 µg/mL for the fruit extract and the leaves extract respectively. A total of 102 common targets and 77 active plant compounds were discovered, of which 37 are potential drug candidates. There were 10 hub targets identified by the PPI network. The hub targets are linked to pathways in cell proliferation and cancer. The best overall binding affinity was demonstrated by repenin A in binding with AURKA, CDK1, and EGFR. Conclusion This study was able to accurately predict the active ingredients and potential targets used in Duranta erecta's treatment of breast cancer. This study offers a fresh approach to future deeper studies on the molecular mechanisms of the plant and its compounds in breast cancer.

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Section: Discussionmentioning

confidence: 99%

Integrating network pharmacology and pharmacological evaluation to investigate the anticancer effects of Duranta erecta Linn. Verbenaceae in breast cancer

Agbana¹,

Abu²,

Akinleye³

et al. 2023

Preprint

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“…For instance, farrerol induced cancer cell death through ERK activation in SKOV3 cells [ 23 ]. Scutellarein induced apoptosis and inhibited the proliferation, migration, and invasion of OC cells by blocking EZH2/FOXO1 signaling [ 24 ]. Liu et al reported that alkannin inhibited the viability, adhesion, invasion, and migration of human gastric cancer cell line MGC-803 through the toll-like receptor 2/nuclear factor-kappa B pathway [ 25 ].…”

Section: Discussionmentioning

confidence: 99%

Alkannin Inhibits the Development of Ovarian Cancer by Affecting miR-4461

Wang

Zhang

Wang

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Background. Previous studies have shown that alkannin has anticancer, anti-inflammatory, and antibacterial effects. However, the effect of alkannin in the development of ovarian cancer (OC) remains unknown. Therefore, this study aims to elucidate the function of alkannin in OC progression. Methods. RT-qPCR and western blot analysis were used to measure mRNA and protein expression. Cell viability and metastasis were detected by the CCK-8 assay, flow cytometry analysis, and transwell assay. Results. Alkannin had no cytotoxicity toward normal ovarian cells, but alkannin can inhibit cell proliferation and induce apoptosis in OC cells. In addition, alkannin inhibited cell migration and invasion and blocked EMT in OC. Besides, upregulation of miR-4461 was found in OC tissues and cells, which was regulated by alkannin. More importantly, miR-4461 can inverse the effects of alkannin on cell viability and metastasis in OC cells. Conclusion. Alkannin restrains cell viability, metastasis, and EMT in OC by downregulating miR-4461 expression.

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“…Additionally, it was found that scutellarin promoted apoptosis and autophagy by activating the HIPPO–YAP signaling pathway, supporting the potential therapeutic application of scutellarin-based drugs to provide patients with breast cancer the best possible outcomes [ 151 , 152 ]. The potential benefits of scutellarin and scutellarein need more clinical investigation for cancer treatment and as a newer therapeutic option [ 153 , 154 , 155 , 156 , 157 ].…”

Section: Regulation Of Autophagy By Scutellaria Fl...mentioning

confidence: 99%

Autophagy Induction by Scutellaria Flavones in Cancer: Recent Advances

Tuli

Bhushan

Kumar³

et al. 2023

Pharmaceuticals

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In parallel with a steady rise in cancer incidence worldwide, the scientific community is increasingly focused on finding novel, safer and more efficient modalities for managing this disease. Over the past decades, natural products have been described as a significant source of new structural leads for novel drug candidates. Scutellaria root is one of the most studied natural products because of its anticancer potential. Besides just describing the cytotoxic properties of plant constituents, their molecular mechanisms of action in different cancer types are equally important. Therefore, this review article focuses on the role of the Scutellaria flavones wogonin, baicalein, baicalin, scutellarein and scutellarin in regulating the autophagic machinery in diverse cancer models, highlighting these molecules as potential lead compounds for the fight against malignant neoplasms. The knowledge that autophagy can function as a dual-edged sword, acting in both a pro- and antitumorigenic manner, further complicates the issue, revealing an amazing property of flavonoids that behave either as anti- or proautophagic agents.

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Scutellarein induces apoptosis and inhibits proliferation, migration, and invasion in ovarian cancer via inhibition of EZH2/FOXO1 signaling

Cited by 18 publications

References 39 publications

Integrating network pharmacology and pharmacological evaluation to investigate the anticancer effects of Duranta erecta Linn. Verbenaceae in breast cancer

Integrating network pharmacology and pharmacological evaluation to investigate the anticancer effects of Duranta erecta Linn. Verbenaceae in breast cancer

Alkannin Inhibits the Development of Ovarian Cancer by Affecting miR-4461

Autophagy Induction by Scutellaria Flavones in Cancer: Recent Advances

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