Scutellaria barbata D. Don inhibits colorectal cancer growth via suppression of Wnt/β-catenin signaling pathway

Wei, Lihui; Lin, Jiumao; Chu, Jianfeng; Chen, Hongwei; Li, Qingyu; Peng, Jun

doi:10.1007/s11655-017-2775-3

Cited by 28 publications

(18 citation statements)

References 21 publications

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“…More importantly, this compound has shown potent inhibitory effects on tumor growth in mice bearing HCT116 xenograft tumors, without causing significant changes in the average body weights of mice ( Ye et al., 2019 ). Wei et al have found that ethanol extract of Scutellaria barbata D. Don (EESB) inhibits the viability and proliferation of colon cancer HT-29 cells in vitro and suppresses the growth of HT-29 xenograft tumors in vivo ( Wei et al., 2017 ). Mechanism of action studies have indicated that EESB induces β-catenin phosphorylation and reduces the expression level of total β-catenin in HT-29 cells ( Wei et al., 2017 ).…”

Section: Natural Product Inhibitors Of β-Catenin Signaling Pathwaymentioning

confidence: 99%

“…Wei et al have found that ethanol extract of Scutellaria barbata D. Don (EESB) inhibits the viability and proliferation of colon cancer HT-29 cells in vitro and suppresses the growth of HT-29 xenograft tumors in vivo ( Wei et al., 2017 ). Mechanism of action studies have indicated that EESB induces β-catenin phosphorylation and reduces the expression level of total β-catenin in HT-29 cells ( Wei et al., 2017 ). However, the active components in EESB that are responsible for EESB-induced β-catenin phosphorylation are yet to be determined.…”

Section: Natural Product Inhibitors Of β-Catenin Signaling Pathwaymentioning

confidence: 99%

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Targeting β-Catenin Signaling by Natural Products for Cancer Prevention and Therapy

et al. 2020

Front. Pharmacol.

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The mutations and deregulation of Wnt signaling pathway occur commonly in human cancer and cause the aberrant activation of b-catenin and b-catenin-dependent transcription, thus contributing to cancer development and progression. Therefore, bcatenin has been demonstrated as a promising target for cancer prevention and therapy. Many natural products have been characterized as inhibitors of the b-catenin signaling through down-regulating b-catenin expression, modulating its phosphorylation, promoting its ubiquitination and proteasomal degradation, inhibiting its nuclear translocation, or other molecular mechanisms. These natural product inhibitors have shown preventive and therapeutic efficacy in various cancer models in vitro and in vivo. In the present review, we comprehensively discuss the natural product b-catenin inhibitors, their in vitro and in vivo anticancer activities, and underlying molecular mechanisms. We also discuss the current b-catenin-targeting strategies and other potential strategies that may be examined for identifying new b-catenin inhibitors as cancer preventive and therapeutic drugs.

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Section: Natural Product Inhibitors Of β-Catenin Signaling Pathwaymentioning

confidence: 99%

Section: Natural Product Inhibitors Of β-Catenin Signaling Pathwaymentioning

confidence: 99%

Targeting β-Catenin Signaling by Natural Products for Cancer Prevention and Therapy

et al. 2020

Front. Pharmacol.

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“…SB extract treatment significantly suppressed the activation of several colorectal cancer-related pathways, including STAT3, Erk, and p38 signalings in tumor tissues, and altered the expression of multiple critical target genes such as Bcl-2, Bax, cyclin D1, CDK4, and p21 (Lin et al, 2014). It was also shown that SD inhibited colorectal cancer growth via suppression of Wnt/b-catenin signaling pathway (Wei et al, 2017). HD-SB combination has long been used as a classic herb pair for cancer treatment, and clinical practices show that HD-SB combination exhibits better therapeutic effects than the two single individuals (Yeh et al, 2014).…”

Section: Introductionmentioning

confidence: 93%

Antitumor Effects and the Compatibility Mechanisms of Herb Pair Scleromitrion diffusum (Willd.) R. J. Wang–Sculellaria barbata D. Don

Zhan

Liu

et al. 2020

Front. Pharmacol.

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Herb pair Scleromitrion diffusum (Willd.) R. J. Wang (HD) and Scutellaria barbata D. Don (SB) has been most frequently used for cancer treatment in traditional Chinese medicine. This study aimed to explore the in vitro and in vivo antitumor effects of HD-SB extract and to elucidate the underlying compatibility mechanisms. HD, SB, and HD-SB extracts were prepared, and the components were detected by ultraperformance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry method. The in vitro antitumor effects of various concentrations of these extract were detected on several tumor cell lines using MTS assay. The in vivo antitumor effects were evaluated in Panc28 cells-bearing nude mice model. The compatibility mechanisms of herb pair HD-SB were evaluated based on the systems pharmacology strategy and then validated by cellular experiments. HD-SB extract was demonstrated to inhibit the proliferation of the cancer cell lines dose dependently by MTS assay. In vivo antitumor effects of HD-SB were much more potent than either of the two single herbs in Panc28 xenograft mice model. A total 29 active ingredients involved in antitumor effects were selected from HD and SB, and the "herb-composition-target-disease" network was constructed. Then, 58 cancerrelated targets and 66 KEGG pathways were identified, and PTGS2-, HSP90-, EGFR-, MMP2-, PPARg-, and GSTP-mediated pathways were predicted to be the antitumor mechanisms of HD-SB. The cellular experiments showed that HD-SB significantly induced cancer cell apoptosis, decreased p-EGFR, HSP90 and bcl-2 expressions, and increased PPARg, bax, cleaved caspase 3, cleaved PARP, p-AKT, and p-PI3K expressions compared with HD or SB treatment. Our study showed that HD-SB inhibited tumor growth both in vitro and in vivo, which might be related with apoptosis induction via the EGFR/PPARg/PI3K/AKT pathway.

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“…This protein is under-expressed in cancer cells and is related to poor clinical outcome through the blockage of apoptosis by caspase inhibition [ 178 ]. Significant reductions of survivin levels were observed for Micromeria fruticosa aerial part extract in MCF-7 and HCT-116 cell lines [ 143 , 144 ], Origanum majorana leaf extract in HT-29 cells [ 171 ], and for Scutellaria barbata whole plant extract in HT-29 cells [ 179 ]. Another key molecule that plays a crucial role in the negative regulation of apoptosis is Her2, belonging to the human epidermal growth factor receptor family.…”

Section: The Lamiaceae Family Plantsmentioning

confidence: 99%

“…CDK/cyclin complexes control Wnt/β-catenin signaling [ 190 ]. Scutellaria barbata extract is related to decreased the expression of β-catenin in HT-29 cells [ 179 ], which is a component of the Wnt/β-catenin signaling pathway responsible for regulating cell growth. The signaling cascade is triggered by binding Wnt ligands to their receptors called Frizzled (Fz) and LDL receptor-related proteins 5 and 6 (LRP5 and LRP6).…”

Section: The Lamiaceae Family Plantsmentioning

confidence: 99%

An In Vitro Evaluation of the Molecular Mechanisms of Action of Medical Plants from the Lamiaceae Family as Effective Sources of Active Compounds against Human Cancer Cell Lines

Sitarek

Merecz-Sadowska

Śliwiński

et al. 2020

Cancers

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It is predicted that 1.8 million new cancer cases will be diagnosed worldwide in 2020; of these, the incidence of lung, colon, breast, and prostate cancers will be 22%, 9%, 7%, and 5%, respectively according to the National Cancer Institute. As the global medical cost of cancer in 2020 will exceed about $150 billion, new approaches and novel alternative chemoprevention molecules are needed. Research indicates that the plants of the Lamiaceae family may offer such potential. The present study reviews selected species from the Lamiaceae and their active compounds that may have the potential to inhibit the growth of lung, breast, prostate, and colon cancer cells; it examines the effects of whole extracts, individual compounds, and essential oils, and it discusses their underlying molecular mechanisms of action. The studied members of the Lamiaceae are sources of crucial phytochemicals that may be important modulators of cancer-related molecular targets and can be used as effective factors to support anti-tumor treatment.

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Scutellaria barbata D. Don inhibits colorectal cancer growth via suppression of Wnt/β-catenin signaling pathway

Abstract: EESB significantly reduced tumor growth in CRC xenografts mice, and inhibited the viability and survival of HT-29 cells. EESB could suppress the activation of the Wnt/β-catenin pathway, which might be one of the mechanisms whereby Scutellaria barbata D. Don exerts its anticancer activity.

Cited by 28 publications

References 21 publications

Targeting β-Catenin Signaling by Natural Products for Cancer Prevention and Therapy

Targeting β-Catenin Signaling by Natural Products for Cancer Prevention and Therapy

Antitumor Effects and the Compatibility Mechanisms of Herb Pair Scleromitrion diffusum (Willd.) R. J. Wang–Sculellaria barbata D. Don

An In Vitro Evaluation of the Molecular Mechanisms of Action of Medical Plants from the Lamiaceae Family as Effective Sources of Active Compounds against Human Cancer Cell Lines

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