SDC3 acts as a timekeeper of myogenic differentiation by regulating the insulin/AKT/mTOR axis in muscle stem cell progeny

Jones, Fiona K.; Jones, Andrew R.; Pisconti, Addolorata

doi:10.1101/2020.08.10.244152

Cited by 3 publications

(2 citation statements)

References 67 publications

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“…50 Upon myogenic differentiation, syndecan-3 reduces the activity of insulin receptor after interaction with AKT/mTOR pathway. 51 It was suggested that modulation of miR-143-3p and miR-100-5p via the mTOR pathway is involved in driving human MSC fate for tissue regeneration. 52 Both miRNAs act as mechanosensitive factors and their expression can be changed in response to matrix stiffness and RhoA activity.…”

Section: Mtor Pathway Role In Differentiation and Stemness Maintenancementioning

confidence: 99%

“…Upon myogenic differentiation, syndecan‐3 reduces the activity of insulin receptor after interaction with AKT/mTOR pathway. 51 It was suggested that modulation of miR‐143‐3p and miR‐100‐5p via the mTOR pathway is involved in driving human MSC fate for tissue regeneration. 52 Both miRNAs act as mechanosensitive factors and their expression can be changed in response to matrix stiffness and RhoA activity.…”

Section: Mtor Pathway Role In Differentiation and Stemness M...mentioning

confidence: 99%

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mTORsignalling pathway in stem cell bioactivities and angiogenesis potential

Lotfimehr,

Mardi,

Narimani

et al. 2023

Cell Proliferation

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The mammalian target of rapamycin (mTOR) is a protein kinase that responds to different stimuli such as stresses, starvation and hypoxic conditions. The modulation of this effector can lead to the alteration of cell dynamic growth, proliferation, basal metabolism and other bioactivities. Considering this fact, the mTOR pathway is believed to regulate the diverse functions in several cell lineages. Due to the pleiotropic effects of the mTOR, we here, hypothesize that this effector can also regulate the bioactivity of stem cells in response to external stimuli pathways under physiological and pathological conditions. As a correlation, we aimed to highlight the close relationship between the mTOR signalling axis and the regenerative potential of stem cells in a different milieu. The relevant publications were included in this study using electronic searches of the PubMed database from inception to February 2023. We noted that the mTOR signalling cascade can affect different stem cell bioactivities, especially angiogenesis under physiological and pathological conditions. Modulation of mTOR signalling pathways is thought of as an effective strategy to modulate the angiogenic properties of stem cells.

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Section: Mtor Pathway Role In Differentiation and Stemness Maintenancementioning

confidence: 99%

Section: Mtor Pathway Role In Differentiation and Stemness M...mentioning

confidence: 99%

mTORsignalling pathway in stem cell bioactivities and angiogenesis potential

Lotfimehr,

Mardi,

Narimani

et al. 2023

Cell Proliferation

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Syndecan-3: A Signaling Conductor in the Musculoskeletal System

Jones

Kehoe

Daroszewska

et al. 2021

Proteoglycans in Stem Cells

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Integrating Physical and Biochemical Cues for Muscle Engineering: Scaffolds and Graft Durability

Yousefi,

Foster,

Selim

et al. 2024

Bioengineering

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Muscle stem cells (MuSCs) are essential for skeletal muscle regeneration, influenced by a complex interplay of mechanical, biochemical, and molecular cues. Properties of the extracellular matrix (ECM) such as stiffness and alignment guide stem cell fate through mechanosensitive pathways, where forces like shear stress translate into biochemical signals, affecting cell behavior. Aging introduces senescence which disrupts the MuSC niche, leading to reduced regenerative capacity via epigenetic alterations and metabolic shifts. Transplantation further challenges MuSC viability, often resulting in fibrosis driven by dysregulated fibro-adipogenic progenitors (FAPs). Addressing these issues, scaffold designs integrated with pharmacotherapy emulate ECM environments, providing cues that enhance graft functionality and endurance. These scaffolds facilitate the synergy between mechanotransduction and intracellular signaling, optimizing MuSC proliferation and differentiation. Innovations utilizing human pluripotent stem cell-derived myogenic progenitors and exosome-mediated delivery exploit bioactive properties for targeted repair. Additionally, 3D-printed and electrospun scaffolds with adjustable biomechanical traits tackle scalability in treating volumetric muscle loss. Advanced techniques like single-cell RNA sequencing and high-resolution imaging unravel muscle repair mechanisms, offering precise mapping of cellular interactions. Collectively, this interdisciplinary approach fortifies tissue graft durability and MuSC maintenance, propelling therapeutic strategies for muscle injuries and degenerative diseases.

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SDC3 acts as a timekeeper of myogenic differentiation by regulating the insulin/AKT/mTOR axis in muscle stem cell progeny

Cited by 3 publications

References 67 publications

mTORsignalling pathway in stem cell bioactivities and angiogenesis potential

mTORsignalling pathway in stem cell bioactivities and angiogenesis potential

Syndecan-3: A Signaling Conductor in the Musculoskeletal System

Integrating Physical and Biochemical Cues for Muscle Engineering: Scaffolds and Graft Durability

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