SDF-1 and PDGF enhance αvβ5-mediated ERK activation and adhesion-independent growth of human pre-B cell lines

Acharya, Mridu; Edkins, Adrienne L.; Ozanne, Brad; Cushley, William

doi:10.1038/leu.2009.126

Cited by 13 publications

(12 citation statements)

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“…Cross-talk between PDGF and CXCL12 in regulating integrin-dependent pre-B cell proliferation was described [37], suggesting common downstream signaling mechanisms. Our observation that CXCL12- and PDGFBB-induced chemotaxis are both abolished by intracellular Ca 2+ chelation while not affected by inhibition of c-src, src-like kinases and c-Abl, further suggests common intracellular pathways, strengthening the hypothesis that in glioblastoma CXCR4 and PDGFR are co-activated during single receptor stimulation and cooperate sharing intracellular signaling mechanisms.…”

Section: Discussionmentioning

confidence: 99%

Functional Cross Talk between CXCR4 and PDGFR on Glioblastoma Cells Is Essential for Migration

et al. 2013

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Glioblastoma (GBM) is the most common and aggressive form of brain tumor, characterized by high migratory behavior and infiltration in brain parenchyma which render classic therapeutic approach ineffective. The migratory behaviour of GBM cells could be conditioned by a number of tissue- and glioma-derived cytokines and growth factors. Although the pro-migratory action of CXCL12 on GBM cells in vitro and in vivo is recognized, the molecular mechanisms involved are not clearly identified. In fact the signaling pathways involved in the pro-migratory action of CXCL12 may differ in individual glioblastoma and integrate with those resulting from abnormal expression and activation of growth factor receptors. In this study we investigated whether some of the receptor tyrosine kinases commonly expressed in GBM cells could cooperate with CXCL12/CXCR4 in their migratory behavior. Our results show a functional cross-talk between CXCR4 and PDGFR which appears to be essential for GBM chemotaxis.

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Section: Discussionmentioning

confidence: 99%

Functional Cross Talk between CXCR4 and PDGFR on Glioblastoma Cells Is Essential for Migration

et al. 2013

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“…This interaction is believed to facilitate antigen processing and presentation by antigen-IgE complexes captured by CD23 [46]. [34,51,52], on activated B cells alone [30] and in the presence of immunoglobulin (Ig)E bound to monomeric and trimeric sCD23 [29], and on centrocytes [33]. The lower left-hand panel illustrates effects on CD4 + bone marrow and thymocyte [36] T cell precursors and the lower right-hand panel shows the responses driven by sCD23 in monocyte precursors [35] and mature monocyte/MF [38,47,49,50,61,62].…”

Section: Cd23 Ligands and Signallingmentioning

confidence: 99%

CD23/FcεRII: molecular multi-tasking

Acharya

Borland

Edkins

et al. 2010

Clinical and Experimental Immunology

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159

160

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SummaryCD23 is the low-affinity receptor for immunoglobulin (Ig)E and plays important roles in the regulation of IgE responses. CD23 can be cleaved from cell surfaces to yield a range of soluble CD23 (sCD23) proteins that have pleiotropic cytokine-like activities. The regions of CD23 responsible for interaction with many of its known ligands, including IgE, CD21, major histocompatibility complex (MHC) class II and integrins, have been identified and help to explain the structure-function relationships within the CD23 protein. Translational studies of CD23 underline its credibility as a target for therapeutic intervention strategies and illustrate its involvement in mediating therapeutic effects of antibodies directed at other targets.

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“…SDF-1 is the ligand for CXCR4, which had been considered for many years to be its only receptor. Thus, the SDF-1–CXCR4 axis has a unique and important biological role [19–25]. Support for this notion comes from murine knockout data showing that SDF-1 secreted by BM stromal cells is critical for the colonization of BM by fetal liver-derived HSCs during embryogenesis.…”

Section: Strategies To Enhance Ucb Hscs Homing/engraftmentmentioning

confidence: 99%

Strategies to enhance umbilical cord blood stem cell engraftment in adult patients

Delaney

Ratajczak

Laughlin³

2010

Expert Review of Hematology

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Umbilical cord blood (UCB) has been used successfully as a source of hematopoietic stem cells (HSCs) for allogeneic transplantation in children and adults in the treatment of hematologic diseases. However, compared with marrow or mobilized peripheral blood stem cell grafts from adult donors, significant delays in the rates and kinetics of neutrophil and platelet engraftment are noted after UCB transplant. These differences relate in part to the reduced numbers of HSCs in UCB grafts. To improve the rates and kinetics of engraftment of UCB HSC, several strategies have been proposed, including ex vivo expansion of UCB HSCs, addition of third-party mesenchymal cells, intrabone delivery of HSCs, modulation of CD26 expression, and infusion of two UCB grafts. This article will focus on ex vivo expansion of UCB HSCs and strategies to enhance UCB homing as potential solutions to overcome the problem of low stem cell numbers in a UCB graft.Keywords cord blood transplantation; CXCR4; engraftment; ex vivo expansion; hematopoietic stem cell; Notch; SDF-1; stem cell homing; umbilical cord blood Umbilical cord blood as an alternative source of hematopoietic stem cells for hematopoietic transplantsWith more than 12,000 umbilical cord blood (UCB) transplantations performed since 1988 for the treatment of hematologic malignancies and selected non-malignant disorders, UCB has emerged as an alternative source of hematopoietic stem cells (HSCs) for transplantation. This is especially important for minority patients and patients of mixed ethnicity, where UCB is a particularly attractive alternative donor stem cell source because it is readily available with no † Author for correspondence: Tel.: +1 216 368 5693, mary.laughlin@case.edu.For reprint orders, please contact reprints@expert-reviews.com Financial & competing interests disclosureMary Laughlin has received funding from the NIH (5RC1HL099447-02). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. No writing assistance was utilized in the production of this manuscript. [3,4]. Despite this, the outcomes in adults undergoing HSC transplant with an UCB graft are significantly influenced by the low cell dose of the graft. Numerous clinical studies have consistently demonstrated that the total nucleated cell (TNC) and CD34 + cell doses in cord blood grafts are highly correlated with the rate of neutrophil and platelet engraftment, as well as the incidence of graft failure and early transplant-related complication [5][6][7][8][9][10][11][12][13]. Based on these studies, critical cell-dose thresholds have been established and outcomes for patients receiving less than the generally accepted threshold of over 2.5 × 10 7 TNC/kg are significantly inferior in terms of engraftment, transplant-related mortality and overall survival. For adult patients and children weighing more than 35-40 ...

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SDF-1 and PDGF enhance αvβ5-mediated ERK activation and adhesion-independent growth of human pre-B cell lines

Cited by 13 publications

References 63 publications

Functional Cross Talk between CXCR4 and PDGFR on Glioblastoma Cells Is Essential for Migration

Functional Cross Talk between CXCR4 and PDGFR on Glioblastoma Cells Is Essential for Migration

CD23/FcεRII: molecular multi-tasking

Strategies to enhance umbilical cord blood stem cell engraftment in adult patients

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