SDF-1(CXCL12) polymorphisms in Egyptian patients with systemic lupus erythematosus (SLE): a pilot study

Abstract

SDF-1(CXCL12) is a chemokine that plays an important role in the regulation of migration, proliferation, and differentiation of hematopoietic cells, as well as being involved in the homeostatic and inflammatory traffic of leukocytes. It was suggested that CXCL12 is a key molecule in the development of autoimmunity in the murine model of lupus. It has been demonstrated that SDF-1 has a G801A transition at position 801 in the 3′-untranslated region of the transcript, known as SDF-1-3′G801A. This polymorphism may have an important regulatory function via an increase in the biosynthesis of SDF-1 protein and has been reported in association with autoimmune diseases, such as type 1 diabetes and systemic sclerosis. We investigated the prevalence of SDF-1-3′ G801A genotype in Egyptian patients with systemic lupus erythematosus (SLE) (n=50) and healthy controls (HC) (n= 50) and its relation to SLE manifestations. We found a significant correlation between the SDF-1-3′G801A genotype and the following SLE features: photosensitivity, nephritis, serositis, and vasculitis, and also anticardiolipin antibodies. Our observations suggest that the SDF-1-3′-G801A genotype may be associated with some clinical and laboratory manifestations in patients with SLE.

A Selective Neutraligand for CXCL12/SDF-1α With Beneficial Regulatory Functions in MRL/Lpr Lupus Prone Mice

“…A polymorphism at position 801 in the 3′untranslated region of the CXCL12 transcript that could be present or absent in certain groups of patients, may explain some of these conflicting results and notably the amount of CXCL12 that is produced. This polymorphism (transition from G to A at this position) has been reported in association with diverse autoimmune diseases, including type 1-diabetes, systemic sclerosis and also certain groups of SLE patients (Yousry et al, 2015). A significant correlation between the SDF-1-3′G801A genotype and several typical clinical and biological features of lupus disease (photosensitivity, glomerulonephritis, serositis, vasculitis, anticardiolipin antibodies) has been reported in SLE patients.…”