2021
DOI: 10.1111/jcmm.17110
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SDF‐1 inhibits the dedifferentiation of islet β cells in hyperglycaemia by up‐regulating FoxO1 via binding to CXCR4

Abstract: Islet β cell dedifferentiation is one of the most important mechanisms in the occurrence and development of diabetes. We studied the possible effects of chemokine stromal cell‐derived factor‐1 (SDF‐1) in the dedifferentiation of islet β cells. It was noted that the number of dedifferentiated islet β cells and the expression of SDF‐1 in pancreatic tissues significantly increased with diabetes. In islet β cell experiments, inhibition of SDF‐1 expression resulted in an increase in the number of dedifferentiated c… Show more

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Cited by 9 publications
(5 citation statements)
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“…Consistently, long-term TMAO (100 nM, 9 d) treatment obviously increased Sox9 and Ngn3 mRNA levels in MIN6 cells (Figures 5C and S5C). Similar to the effect of HG (35 mM glucose, 9 d) on β-cell dedifferentiation [29], long-term TMAO treatment increased the protein levels of Sox9, Ngn3 and another dedifferentiation marker, ChgA, in MIN6 cells (Figures 5D and S5D). Consistently, mouse primary islets expressed higher Sox9, Ngn3 and ChgA protein levels after longterm TMAO treatment (Figures 5E and S5E).…”
Section: Tmao Diminished the β-Cell Proportion By Promoting Dediffere...supporting
confidence: 56%
“…Consistently, long-term TMAO (100 nM, 9 d) treatment obviously increased Sox9 and Ngn3 mRNA levels in MIN6 cells (Figures 5C and S5C). Similar to the effect of HG (35 mM glucose, 9 d) on β-cell dedifferentiation [29], long-term TMAO treatment increased the protein levels of Sox9, Ngn3 and another dedifferentiation marker, ChgA, in MIN6 cells (Figures 5D and S5D). Consistently, mouse primary islets expressed higher Sox9, Ngn3 and ChgA protein levels after longterm TMAO treatment (Figures 5E and S5E).…”
Section: Tmao Diminished the β-Cell Proportion By Promoting Dediffere...supporting
confidence: 56%
“…6c). Similar to the effect of high glucose (35 mM glucose, 9 d) on β-cell dedifferentiation 30 , long-term TMAO treatment increased the protein levels of Sox9, Ngn3 and another dedifferentiation marker, namely, chromograin A (ChgA), in MIN6 cells (Fig. 6d and Supplementary Fig.…”
Section: Tmao Diminished the β-Cell Proportion By Promoting Dediffere...supporting
confidence: 53%
“… 8 SDF-1α may also have protective effects in T1D due to AKT phosphorylation downstream of CXCR4 activation, which in turn increases survival and inhibits dedifferentiation of beta cells. 39 , 40 We observed a potent chemotactic effect of SDF-1α on CXCR4+ Jurkat T cells ( Figure 3 (a)). Once released into the extracellular environment, MT acts as a chemoattractant for a number of cell lines and primary cells.…”
Section: Resultsmentioning
confidence: 88%