SDRIFE-Like Rash With COVID - 19

Rare case of itraconazole induced SDRIFE (symmetrical drug‐related intertriginous and flexural exanthema)

“…Yet, the reason why these reactions are site-specific remains unclear. 11,12 The areas of distribution are prone to mechanical friction, heat, and sweat. However, apocrine sweat glands are exclusively found in those exact areas.…”

“…It is still unclear how COVID-19 infections are connected to SDRIFE, but the number of SDRIFE cases has been increasing since the start of the pandemic in 2020. 12,13 Whether the virus itself, the broad immune response, or multimodal treatments including new antiviral agents have caused the rise in case numbers of SDRIFE or SDRIFE-like lesions remains unknown. 14…”