SDS-Stabilized CuInSe2/ZnS Multinanocomposites Prepared by Mechanochemical Synthesis for Advanced Biomedical Application

Abstract

The CuInSe2/ZnS multiparticulate nanocomposites were first synthesized employing two-step mechanochemical synthesis. In the first step, tetragonal CuInSe2 crystals prepared from copper, indium and selenium precursors were co-milled with zinc acetate dihydrate and sodium sulfide nonahydrate as precursors for ZnS in different molar ratios by mechanochemical route in a planetary mill. In the second step, the prepared CuInSe2/ZnS nanocrystals were further milled in a circulation mill in sodium dodecyl sulphate (SDS) solution (0.5 wt.%) to stabilize the synthesized nanoparticles. The sodium dodecyl sulphate capped CuInSe2/ZnS 5:0-SDS nanosuspension was shown to be stable for 20 weeks, whereas the CuInSe2/ZnS 4:1-SDS one was stable for about 11 weeks. After sodium dodecyl sulphate capping, unimodal particle size distribution was obtained with particle size medians approaching, respectively, 123 nm and 188 nm for CuInSe2/ZnS 5:0-SDS and CuInSe2/ZnS 4:1-SDS nanocomposites. Successful stabilization of the prepared nanosuspensions due to sodium dodecyl sulphate covering the surface of the nanocomposite particles was confirmed by zeta potential measurements. The prepared CuInSe2/ZnS 5:0-SDS and CuInSe2/ZnS 4:1-SDS nanosuspensions possessed anti-myeloma sensitizing potential assessed by significantly reduced viability of multiple myeloma cell lines, with efficient fluorescence inside viable cells and higher cytotoxic efficacy in CuInSe2/ZnS 4:1-SDS nanosuspension.

In vitro and ex vivo anti-myeloma effects of nanocomposite As4S4/ZnS/Fe3O4

“…In our previous study, NREA treatment showed significant in vitro (in MM cell lines and primary patient-derived PC) and in vivo anti-MM activity in MM cell line-derived xenograft and MM patient-derived huBMsc mouse models 16 . Similarly, CuInSe2/ZnS multiparticulate nanocomposites in sodium dodecyl sulfate (SDS) nanosuspensions possess anti-myeloma sensitizing potential 59 . The favorable therapeutic window against ex vivo isolated PCs of primary myeloma patients for use of composite NPs suggested that an EC 50 in the range 0.08–2.7 μM was on average 3–6-fold lower than that of non-PCs of the tumor microenvironment (with an EC 50 in the range 2–18.8 μM).…”

Zns Nanocrystals Were Prepared by Co-precipitation Method and Their Structure and Optical Properties Were Studied

“…The semiconductor nano-material play an important role in the fields of photocatalytic [1] hyperthermia [2] as well as biomedical [3] LED applications [4]. The nano materials have excellent structural, electrical, magnetic properties than that of bulk material [5].…”