2018
DOI: 10.1039/c8ra01906a
|View full text |Cite
|
Sign up to set email alerts
|

Se@SiO2 nanocomposites suppress microglia-mediated reactive oxygen species during spinal cord injury in rats

Abstract: Selenium (Se) is an essential trace element with strong antioxidant activity, showing a great prospect in the treatment of spinal cord injury (SCI).

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1
1

Citation Types

1
3
0

Year Published

2022
2022
2024
2024

Publication Types

Select...
7
1

Relationship

0
8

Authors

Journals

citations
Cited by 11 publications
(4 citation statements)
references
References 64 publications
1
3
0
Order By: Relevance
“…Similar to the study by Wang et al. [ 85 ], the intrathecal injection of porous selenium@SiO 2 nanocomposites reduced the toxicity of selenium, sustained its release, and exerted antioxidant effects. Liu et al.…”
Section: Functional Nanomaterials For Sci Treatmentsupporting
confidence: 69%
“…Similar to the study by Wang et al. [ 85 ], the intrathecal injection of porous selenium@SiO 2 nanocomposites reduced the toxicity of selenium, sustained its release, and exerted antioxidant effects. Liu et al.…”
Section: Functional Nanomaterials For Sci Treatmentsupporting
confidence: 69%
“…Secondary injury, including neuro-inflammation, oxidative stress, lipid peroxidation, and electrolyte imbalance are the primary contributors to the aggravated neurological damage and adverse neurological outcomes that follow SCI [ 4 , 33 ]. Microglia-mediated neuro-inflammation and oxidative stress play a major adverse role in the acute phase of SCI [ 34 , 35 ]. Microglia, as the guardians of the nervous system, are activated rapidly after SCI.…”
Section: Discussionmentioning
confidence: 99%
“…In the past few years, several studies have demonstrated that ferroptosis is involved in this second phase of SCI and its inhibition represents an attractive target for the treatment of this injury [111,[121][122][123][124][125][126]. As Se had been previously studied in SCI [127][128][129][130][131][132], the role of Na 2 SeO 3 in ameliorating the neuronal function through the inhibition of ferroptosis has been analyzed. Na 2 SeO 3 administration in a rat model resulted in an enhancement of the expression and activity of GPx4, thus inhibiting ferroptosis and improving the neurological recovery after SCI [107] (Figure 3).…”
Section: Sodium Selenite and Neurodegenerative Diseasesmentioning
confidence: 99%