Seagrass Metabolomics: A New Insight towards Marine Based Drug Discovery

Abstract

Metabolomics is one of the new field of “Omics” approach and the youngest triad of system biology, which provides a broad prospective of how metabolic networks are controlled and indeed emerged as a complementary tool to functional genomics with well-established technologies for genomics, transcriptomics and proteomics. Though, metabolite profiling has been carried out for decades, owing to decisive mechanism of a molecule regulation, the importance of some metabolites in human regimen and their use as diagnostic markers is now being recognized. Plant metabolomics therefore aims to highlight the characterization of metabolite pool of a plant tissue in response to its environment. Seagrassses, a paraphyletic group of marine hydrophilous angiosperms which evolved three to four times from land plants back to the sea. Seagrasses share a number of analogous acquired metabolic adaptations owing to their convergent evolution, but their secondary metabolism varied among the four families that can be considered as true seagrasses. From a chemotaxonomic point of view, numerous specialized metabolites have often been studied in seagrasses. Hence, this chapter focus the metabolome of seagrasses in order to explore their bioactive properties and the recent advancements adopted in analytical technology platforms to study the non-targeted metabolomics of seagrasses using OMICS approach.

New insight on antioxidants and anti-obesity properties of two seagrasses Thalassia hemprichii and Zostera marina: an integrated molecular docking simulation with in vitro study

“…19 Judging from both seagrasses' content (T. hemprichii and Z. marina), they have no less potential than H. stipulacea regarding antioxidant and anti-obesity. 13,14,18 However, research discussing these two marine plants both in terms of metabolites and biological activity is still very limited and unfortunate considering their abundance and availability. Therefore, this study aims to provide new insights related to chemical constituents profiling and biological activity of two seagrasses T. hemprichii and Z. marina in fighting free radicals and obesity via molecular docking and in vitro study.…”

“…12 Seagrasses Thalassia hemprichii and Zostera marina contain substances including cinnamic esters of tartaric acid which are also contained in Halophila stipulacea. 13,14 These metabolites are known to work as antioxidants through the mechanism of free radical scavenging. Free radical scavenging is the ability of the phenol group (-OH) to provide hydrogen ions or electrons that will form stable phenoxy radicals to reduce free radicals circulating in the body.…”

Mini-review on the antimicrobial potential of actinobacteria associated with seagrasses

“…Seagrasses are submerged, marine flowering plants that thrive in the ocean except in the polar regions [20]. They comprise over 60 species, belonging to four exclusive plant families including Zosteraceae, Hydrocharitaceae, Posidoniaceae, and Cymodoceaceae, and support immense levels of biodiversity [21][22][23][24][25]. Seagrasses have a range of features that arose from adapting to living in submerged marine conditions [26,27].…”

“…Among the triad of key marine habitats, seagrass meadows are regarded as one of the most productive and crucial components of the marine ecosystem. They act as nutrient cyclers, sediment stabilizers (coastal protection), organic carbon producers (carbon sequestration), and juvenile nursery grounds and feeding areas for marine life (provide trophic subsidy to contiguous habitats) [24,28,29]. The ecological importance of seagrass meadows is irrefutable, and yet remains poorly studied, in terms of medicinal properties [30].…”

Phytochemical and biochemical analyses of Syringodium isoetifolium (Asch.) Dandy

“…Seagrasses, a convention of marine blossoming plants, possess the flowing and sub-flowing regions of shallow and protected areas of oceans, inlets, bayous, backwaters, tidal ponds, and estuaries around on mild and tropical shorelines of the world (Meena et al, 2022). Globally, 72 species under 4 families (Zosteraceae, Hydrocharitaceae, Posidoniaceae and Cymodoceae) of Seagrasses has been found of which the seagrasses is one of its true marine flowering plants (Short et al, 2016 andJeyapragash et al, 2021). Seagrasses are eukaryotic organisms that can be found, with the exception of the Polar Regions, in shallow water sections of moderate, subtropical, and tropical oceans (Mehari Ghebretinsae et al, 2019).…”